The STIM1-binding site nexus remotely controls Orai1 channel gating

The STIM1-binding site nexus remotely controls Orai1 channel gating

How plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of STIM1 with the channel pore.

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Detalles Bibliográficos
Autores principales: Yandong Zhou, Xiangyu Cai, Natalia A. Loktionova, Xianming Wang, Robert M. Nwokonko, Xizhuo Wang, Youjun Wang, Brad S. Rothberg, Mohamed Trebak, Donald L. Gill
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/319437aa2a59462e85ad73d129f7e2ee
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