Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms

Abstract The vascular complications have been a major cause of morbidity and mortality among all subtypes of BCR-ABL1 negative myeloproliferative neoplasms (MPN), but the ethnicity-specific data was limited. We therefore conducted a multi-center retrospective, longitudinal cohort study to evaluate t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jinyong Kim, Ja Min Byun, Junshik Hong, Youngil Koh, Dong-Yeop Shin, Inho Kim, Sung-Soo Yoon, Hyunkyung Park, Soo-Mee Bang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31965b6eb8e44768b1bf211a5d99e60b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:31965b6eb8e44768b1bf211a5d99e60b
record_format	dspace
spelling	oai:doaj.org-article:31965b6eb8e44768b1bf211a5d99e60b2021-12-02T14:58:46ZIncidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms10.1038/s41598-021-97464-42045-2322https://doaj.org/article/31965b6eb8e44768b1bf211a5d99e60b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97464-4https://doaj.org/toc/2045-2322Abstract The vascular complications have been a major cause of morbidity and mortality among all subtypes of BCR-ABL1 negative myeloproliferative neoplasms (MPN), but the ethnicity-specific data was limited. We therefore conducted a multi-center retrospective, longitudinal cohort study to evaluate the incidence, characteristics and risk factors of thromboembolic events of MPN patients. Of 256 patients, 27.3% experienced thromboembolic events, majority of which occurred before or within 12 months of MPN diagnosis. The multivariable Cox proportional analyses identified leukocytosis (HR 2.67, 95% CI 1.36–5.24, q = 0.004) and history of thrombosis (HR 9.68, 95% CI 2.00–46.88, q = 0.005) as the risk factors for thromboembolism. In subgroup analysis of polycythemia vera and hemoglobin concentration (HR 1.97, 95% CI 1.28–3.04, q = 0.002) appeared to be a significant risk factor of thrombosis, along with age and thrombosis history. In essential thrombocythemia, severity of the established IPSET score was closely correlated with the frequency of thromboembolic events. In primary myelofibrosis, history of thrombosis was associated with thrombosis events (HR 13.85, 95% CI 1.2–159.5, q = 0.035). Overall survival was worse in patients who experienced thromboembolic events. Our study highlighted the importance of recognizing high risk patients and implementing personalized intervention.Jinyong KimJa Min ByunJunshik HongYoungil KohDong-Yeop ShinInho KimSung-Soo YoonHyunkyung ParkSoo-Mee BangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinyong Kim Ja Min Byun Junshik Hong Youngil Koh Dong-Yeop Shin Inho Kim Sung-Soo Yoon Hyunkyung Park Soo-Mee Bang Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms
description	Abstract The vascular complications have been a major cause of morbidity and mortality among all subtypes of BCR-ABL1 negative myeloproliferative neoplasms (MPN), but the ethnicity-specific data was limited. We therefore conducted a multi-center retrospective, longitudinal cohort study to evaluate the incidence, characteristics and risk factors of thromboembolic events of MPN patients. Of 256 patients, 27.3% experienced thromboembolic events, majority of which occurred before or within 12 months of MPN diagnosis. The multivariable Cox proportional analyses identified leukocytosis (HR 2.67, 95% CI 1.36–5.24, q = 0.004) and history of thrombosis (HR 9.68, 95% CI 2.00–46.88, q = 0.005) as the risk factors for thromboembolism. In subgroup analysis of polycythemia vera and hemoglobin concentration (HR 1.97, 95% CI 1.28–3.04, q = 0.002) appeared to be a significant risk factor of thrombosis, along with age and thrombosis history. In essential thrombocythemia, severity of the established IPSET score was closely correlated with the frequency of thromboembolic events. In primary myelofibrosis, history of thrombosis was associated with thrombosis events (HR 13.85, 95% CI 1.2–159.5, q = 0.035). Overall survival was worse in patients who experienced thromboembolic events. Our study highlighted the importance of recognizing high risk patients and implementing personalized intervention.
format	article
author	Jinyong Kim Ja Min Byun Junshik Hong Youngil Koh Dong-Yeop Shin Inho Kim Sung-Soo Yoon Hyunkyung Park Soo-Mee Bang
author_facet	Jinyong Kim Ja Min Byun Junshik Hong Youngil Koh Dong-Yeop Shin Inho Kim Sung-Soo Yoon Hyunkyung Park Soo-Mee Bang
author_sort	Jinyong Kim
title	Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms
title_short	Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms
title_full	Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms
title_fullStr	Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms
title_full_unstemmed	Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms
title_sort	incidence, characteristics and risk factors of thromboembolic events in east asian patients with bcr-abl1 negative myeloproliferative neoplasms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/31965b6eb8e44768b1bf211a5d99e60b
work_keys_str_mv	AT jinyongkim incidencecharacteristicsandriskfactorsofthromboemboliceventsineastasianpatientswithbcrabl1negativemyeloproliferativeneoplasms AT jaminbyun incidencecharacteristicsandriskfactorsofthromboemboliceventsineastasianpatientswithbcrabl1negativemyeloproliferativeneoplasms AT junshikhong incidencecharacteristicsandriskfactorsofthromboemboliceventsineastasianpatientswithbcrabl1negativemyeloproliferativeneoplasms AT youngilkoh incidencecharacteristicsandriskfactorsofthromboemboliceventsineastasianpatientswithbcrabl1negativemyeloproliferativeneoplasms AT dongyeopshin incidencecharacteristicsandriskfactorsofthromboemboliceventsineastasianpatientswithbcrabl1negativemyeloproliferativeneoplasms AT inhokim incidencecharacteristicsandriskfactorsofthromboemboliceventsineastasianpatientswithbcrabl1negativemyeloproliferativeneoplasms AT sungsooyoon incidencecharacteristicsandriskfactorsofthromboemboliceventsineastasianpatientswithbcrabl1negativemyeloproliferativeneoplasms AT hyunkyungpark incidencecharacteristicsandriskfactorsofthromboemboliceventsineastasianpatientswithbcrabl1negativemyeloproliferativeneoplasms AT soomeebang incidencecharacteristicsandriskfactorsofthromboemboliceventsineastasianpatientswithbcrabl1negativemyeloproliferativeneoplasms
_version_	1718389256050704384

Incidence, characteristics and risk factors of thromboembolic events in East Asian patients with BCR-ABL1 negative myeloproliferative neoplasms

Ejemplares similares