Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.

<h4>Background and purpose</h4>Determinants of post-acute stroke outcomes in Africa have been less investigated. We assessed the association of metabolic syndrome (MetS) and insulin resistance with post-stroke mortality in patients with first-ever-in-lifetime stroke in the capital city o...

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Autores principales:	Eric Vounsia Balti, André Pascal Kengne, Jean Valentin Fogha Fokouo, Brice Enid Nouthé, Eugene Sobngwi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3198cacf1f3a443391eb9ca0acb2beba
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spelling	oai:doaj.org-article:3198cacf1f3a443391eb9ca0acb2beba2021-11-18T07:51:03ZMetabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.1932-620310.1371/journal.pone.0060117https://doaj.org/article/3198cacf1f3a443391eb9ca0acb2beba2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23565192/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and purpose</h4>Determinants of post-acute stroke outcomes in Africa have been less investigated. We assessed the association of metabolic syndrome (MetS) and insulin resistance with post-stroke mortality in patients with first-ever-in-lifetime stroke in the capital city of Cameroon (sub-Saharan Africa).<h4>Methods</h4>Patients with an acute first-stroke event (n = 57) were recruited between May and October 2006, and followed for 5 years for mortality outcome. MetS definition was based on the Joint Interim Statement 2009, insulin sensitivity/resistance assessed via glucose-to-insulin ratio, quantitative insulin sensitivity check index and homeostatic model assessment.<h4>Results</h4>Overall, 24 (42%) patients deceased during follow-up. The prevalence of MetS was higher in patients who died after 28 days, 1 year and 5 years from any cause or cardiovascular-related causes (all p≤0.040). MetS was associated with an increased overall mortality both after 1 year (39% vs. 9%) and 5 years of follow-up (55% vs. 26%, p = 0.022). Similarly, fatal events due to cardiovascular-related conditions were more frequent in the presence of MetS both 1 year (37% vs. 9%) and 5 years after the first-ever-in-lifetime stroke (43% vs. 13%, p = 0.017). Unlike biochemical measures of insulin sensitivity and resistance (non-significant), in age- and sex-adjusted Cox models, MetS was associated with hazard ratio (95% CI) of 2.63 (1.03-6.73) and 3.54 (1.00-12.56) respectively for all-cause and cardiovascular mortality 5 years after stroke onset.<h4>Conclusion</h4>The Joint Interim Statement 2009 definition of MetS may aid the identification of a subgroup of black African stroke patients who may benefit from intensification of risk factor management.Eric Vounsia BaltiAndré Pascal KengneJean Valentin Fogha FokouoBrice Enid NouthéEugene SobngwiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60117 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eric Vounsia Balti André Pascal Kengne Jean Valentin Fogha Fokouo Brice Enid Nouthé Eugene Sobngwi Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.
description	<h4>Background and purpose</h4>Determinants of post-acute stroke outcomes in Africa have been less investigated. We assessed the association of metabolic syndrome (MetS) and insulin resistance with post-stroke mortality in patients with first-ever-in-lifetime stroke in the capital city of Cameroon (sub-Saharan Africa).<h4>Methods</h4>Patients with an acute first-stroke event (n = 57) were recruited between May and October 2006, and followed for 5 years for mortality outcome. MetS definition was based on the Joint Interim Statement 2009, insulin sensitivity/resistance assessed via glucose-to-insulin ratio, quantitative insulin sensitivity check index and homeostatic model assessment.<h4>Results</h4>Overall, 24 (42%) patients deceased during follow-up. The prevalence of MetS was higher in patients who died after 28 days, 1 year and 5 years from any cause or cardiovascular-related causes (all p≤0.040). MetS was associated with an increased overall mortality both after 1 year (39% vs. 9%) and 5 years of follow-up (55% vs. 26%, p = 0.022). Similarly, fatal events due to cardiovascular-related conditions were more frequent in the presence of MetS both 1 year (37% vs. 9%) and 5 years after the first-ever-in-lifetime stroke (43% vs. 13%, p = 0.017). Unlike biochemical measures of insulin sensitivity and resistance (non-significant), in age- and sex-adjusted Cox models, MetS was associated with hazard ratio (95% CI) of 2.63 (1.03-6.73) and 3.54 (1.00-12.56) respectively for all-cause and cardiovascular mortality 5 years after stroke onset.<h4>Conclusion</h4>The Joint Interim Statement 2009 definition of MetS may aid the identification of a subgroup of black African stroke patients who may benefit from intensification of risk factor management.
format	article
author	Eric Vounsia Balti André Pascal Kengne Jean Valentin Fogha Fokouo Brice Enid Nouthé Eugene Sobngwi
author_facet	Eric Vounsia Balti André Pascal Kengne Jean Valentin Fogha Fokouo Brice Enid Nouthé Eugene Sobngwi
author_sort	Eric Vounsia Balti
title	Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.
title_short	Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.
title_full	Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.
title_fullStr	Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.
title_full_unstemmed	Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.
title_sort	metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in cameroon.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/3198cacf1f3a443391eb9ca0acb2beba
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Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.

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