Malignant hyperthermia: current approaches to prevention and treatment

One of the most serious complications of modern anesthesia is malignant hyperthermia, which is a pharmacogenetic disease phenotype manifested by skeletal muscle hypermetabolism and rhabdomyolysis during or after general anesthesia with the use of inhaled anesthetics and succinylcholine. In Russia, t...

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Autores principales:	E. S. Kim, V. I. Gorbachev, V. V. Unzhakov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	malignant hyperthermia prevention of malignant hyperthermia treatment of malignant hyperthermia dantrolene Science Q
Acceso en línea:	https://doaj.org/article/319a689488a148e3a9868d51e9c317a9
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spelling	oai:doaj.org-article:319a689488a148e3a9868d51e9c317a92021-11-23T06:14:39ZMalignant hyperthermia: current approaches to prevention and treatment2541-94202587-959610.12737/article_5a3a0ef02e9901.72007754https://doaj.org/article/319a689488a148e3a9868d51e9c317a92017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/526https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596One of the most serious complications of modern anesthesia is malignant hyperthermia, which is a pharmacogenetic disease phenotype manifested by skeletal muscle hypermetabolism and rhabdomyolysis during or after general anesthesia with the use of inhaled anesthetics and succinylcholine. In Russia, the problem of malignant hyperthermia remains unresolved. This is mainly due to the fact that the only specific drug dantrolene created for the effective treatment of malignant hyperthermia is still not legalized and thus formally prohibited to import, disseminate and apply on the domestic pharmaceutical market. This article deals with the regulatory framework of specific treatment of malignant hyperthermia in Russia, allowing the possibility to legally import to the territory of the Russian Federation dantrolene as an unregistered drug, if it is a question of rendering medical assistance on vital indications to a particular patient, or its unauthorized use for vital indications in a situation of extreme necessity. The article presents the recommendations of domestic experts on the treatment of malignant hyperthermia. In this case, as a possible alternative to dantrolene, magnesium preparations are considered, whose role in the treatment of the crisis of malignant hyperthermia continues to be specified. Thus, given the increasing use of inhalation anesthesia by Russian anesthetists, to ensure the safety of patients with regard to the development of malignant hyperthermia, it is possible only in the case of official registration in the domestic dantrolene market. Also, in the territory of Russia, a network of relevant consultative and diagnostic centers should be established. These measures will undoubtedly increase the effectiveness of treatment and prevention of severe consequences of this disease in our country.E. S. KimV. I. GorbachevV. V. UnzhakovScientific Сentre for Family Health and Human Reproduction Problemsarticlemalignant hyperthermiaprevention of malignant hyperthermiatreatment of malignant hyperthermiadantroleneScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(2), Pp 154-158 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	malignant hyperthermia prevention of malignant hyperthermia treatment of malignant hyperthermia dantrolene Science Q
spellingShingle	malignant hyperthermia prevention of malignant hyperthermia treatment of malignant hyperthermia dantrolene Science Q E. S. Kim V. I. Gorbachev V. V. Unzhakov Malignant hyperthermia: current approaches to prevention and treatment
description	One of the most serious complications of modern anesthesia is malignant hyperthermia, which is a pharmacogenetic disease phenotype manifested by skeletal muscle hypermetabolism and rhabdomyolysis during or after general anesthesia with the use of inhaled anesthetics and succinylcholine. In Russia, the problem of malignant hyperthermia remains unresolved. This is mainly due to the fact that the only specific drug dantrolene created for the effective treatment of malignant hyperthermia is still not legalized and thus formally prohibited to import, disseminate and apply on the domestic pharmaceutical market. This article deals with the regulatory framework of specific treatment of malignant hyperthermia in Russia, allowing the possibility to legally import to the territory of the Russian Federation dantrolene as an unregistered drug, if it is a question of rendering medical assistance on vital indications to a particular patient, or its unauthorized use for vital indications in a situation of extreme necessity. The article presents the recommendations of domestic experts on the treatment of malignant hyperthermia. In this case, as a possible alternative to dantrolene, magnesium preparations are considered, whose role in the treatment of the crisis of malignant hyperthermia continues to be specified. Thus, given the increasing use of inhalation anesthesia by Russian anesthetists, to ensure the safety of patients with regard to the development of malignant hyperthermia, it is possible only in the case of official registration in the domestic dantrolene market. Also, in the territory of Russia, a network of relevant consultative and diagnostic centers should be established. These measures will undoubtedly increase the effectiveness of treatment and prevention of severe consequences of this disease in our country.
format	article
author	E. S. Kim V. I. Gorbachev V. V. Unzhakov
author_facet	E. S. Kim V. I. Gorbachev V. V. Unzhakov
author_sort	E. S. Kim
title	Malignant hyperthermia: current approaches to prevention and treatment
title_short	Malignant hyperthermia: current approaches to prevention and treatment
title_full	Malignant hyperthermia: current approaches to prevention and treatment
title_fullStr	Malignant hyperthermia: current approaches to prevention and treatment
title_full_unstemmed	Malignant hyperthermia: current approaches to prevention and treatment
title_sort	malignant hyperthermia: current approaches to prevention and treatment
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/319a689488a148e3a9868d51e9c317a9
work_keys_str_mv	AT eskim malignanthyperthermiacurrentapproachestopreventionandtreatment AT vigorbachev malignanthyperthermiacurrentapproachestopreventionandtreatment AT vvunzhakov malignanthyperthermiacurrentapproachestopreventionandtreatment
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Malignant hyperthermia: current approaches to prevention and treatment

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