Effects of prenatal oral l-arginine on birth outcomes: a meta-analysis
Abstract Adverse birth outcomes are associated with elevated mortality and morbidity rates throughout life. This meta-analysis of randomised controlled trials examined whether prenatal oral l-arginine has effects on birth outcomes. A total of 45 overall good quality studies were extracted from 10 fi...
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Nature Portfolio
2021
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oai:doaj.org-article:319ae7c46e6143d28bae7445c70e31df2021-11-28T12:16:19ZEffects of prenatal oral l-arginine on birth outcomes: a meta-analysis10.1038/s41598-021-02182-62045-2322https://doaj.org/article/319ae7c46e6143d28bae7445c70e31df2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02182-6https://doaj.org/toc/2045-2322Abstract Adverse birth outcomes are associated with elevated mortality and morbidity rates throughout life. This meta-analysis of randomised controlled trials examined whether prenatal oral l-arginine has effects on birth outcomes. A total of 45 overall good quality studies were extracted from 10 finally eligible articles. In comparison to controls, providing oral l-arginine to women with a history of poor pregnancy outcomes significantly reduced risks of intrauterine growth retardation neonates, pre-term birth and respiratory distress syndrome (n = 7, 3 and 3, respectively) and significantly increased birthweight and gestational age (n = 8 and 5, respectively) l-Arginine significantly increased Apgar score in women at high risk of pre-eclampsia or with pre-eclampsia or gestational or mild chronic hypertension in comparison to controls (n = 4). l-Arginine showed no significant effect on any other outcome examined (n = 2). The quality of evidence was at least medium or high. Consequently, oral l-arginine may be at least moderately recommended for women with a history of poor pregnancy outcomes and at high risk of pre-eclampsia or with pre-eclampsia or gestational or mild chronic hypertension. However, further studies are required to provide stronger conclusions, partly due to small study effects.Eita GotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Eita Goto Effects of prenatal oral l-arginine on birth outcomes: a meta-analysis |
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Abstract Adverse birth outcomes are associated with elevated mortality and morbidity rates throughout life. This meta-analysis of randomised controlled trials examined whether prenatal oral l-arginine has effects on birth outcomes. A total of 45 overall good quality studies were extracted from 10 finally eligible articles. In comparison to controls, providing oral l-arginine to women with a history of poor pregnancy outcomes significantly reduced risks of intrauterine growth retardation neonates, pre-term birth and respiratory distress syndrome (n = 7, 3 and 3, respectively) and significantly increased birthweight and gestational age (n = 8 and 5, respectively) l-Arginine significantly increased Apgar score in women at high risk of pre-eclampsia or with pre-eclampsia or gestational or mild chronic hypertension in comparison to controls (n = 4). l-Arginine showed no significant effect on any other outcome examined (n = 2). The quality of evidence was at least medium or high. Consequently, oral l-arginine may be at least moderately recommended for women with a history of poor pregnancy outcomes and at high risk of pre-eclampsia or with pre-eclampsia or gestational or mild chronic hypertension. However, further studies are required to provide stronger conclusions, partly due to small study effects. |
| format |
article |
| author |
Eita Goto |
| author_facet |
Eita Goto |
| author_sort |
Eita Goto |
| title |
Effects of prenatal oral l-arginine on birth outcomes: a meta-analysis |
| title_short |
Effects of prenatal oral l-arginine on birth outcomes: a meta-analysis |
| title_full |
Effects of prenatal oral l-arginine on birth outcomes: a meta-analysis |
| title_fullStr |
Effects of prenatal oral l-arginine on birth outcomes: a meta-analysis |
| title_full_unstemmed |
Effects of prenatal oral l-arginine on birth outcomes: a meta-analysis |
| title_sort |
effects of prenatal oral l-arginine on birth outcomes: a meta-analysis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/319ae7c46e6143d28bae7445c70e31df |
| work_keys_str_mv |
AT eitagoto effectsofprenatalorallarginineonbirthoutcomesametaanalysis |
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