Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature

New drugs come not only with benefits but also with unexpected toxicities which need to be promptly recognized and managed. Starting from a scholar case of acute heart failure with preserved ejection fraction following the administration of trabectedin (ET-743, Yondelis®) in a patient with a metasta...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Julien Catherine, Christiane Jungels, Valerie Durieux, Coralie Deliens, Bogdan Grigoriu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	trabectedin toxicity acute cardiac drug-induced cardiac biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/319c91c1a88040b99fa91a6f2b98a8ad
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:319c91c1a88040b99fa91a6f2b98a8ad
record_format	dspace
spelling	oai:doaj.org-article:319c91c1a88040b99fa91a6f2b98a8ad2021-11-18T04:50:17ZTrabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature2234-943X10.3389/fonc.2021.694620https://doaj.org/article/319c91c1a88040b99fa91a6f2b98a8ad2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.694620/fullhttps://doaj.org/toc/2234-943XNew drugs come not only with benefits but also with unexpected toxicities which need to be promptly recognized and managed. Starting from a scholar case of acute heart failure with preserved ejection fraction following the administration of trabectedin (ET-743, Yondelis®) in a patient with a metastatic solitary fibrous tumor, we performed a systematic review of the literature encompassing the results of previous cardiac safety analysis published ten years ago, a review of clinical trials published during the last 10 years as well as single-case descriptions related to trabectedin cardiotoxicity. The estimated incidence of cardiac toxicity was 3,4% among patients receiving trabectedin, with recent data suggesting a higher rate of heart failure than previously recognized. Previous or concomitant anthracyclines exposure may represent a risk factor. Assaying for NT-pro-BNP may be useful for the early detection of individuals with trabectedin-induced heart failure.Julien CatherineChristiane JungelsValerie DurieuxValerie DurieuxCoralie DeliensBogdan GrigoriuFrontiers Media S.A.articletrabectedintoxicityacutecardiacdrug-inducedcardiac biomarkersNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	trabectedin toxicity acute cardiac drug-induced cardiac biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	trabectedin toxicity acute cardiac drug-induced cardiac biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Julien Catherine Christiane Jungels Valerie Durieux Valerie Durieux Coralie Deliens Bogdan Grigoriu Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature
description	New drugs come not only with benefits but also with unexpected toxicities which need to be promptly recognized and managed. Starting from a scholar case of acute heart failure with preserved ejection fraction following the administration of trabectedin (ET-743, Yondelis®) in a patient with a metastatic solitary fibrous tumor, we performed a systematic review of the literature encompassing the results of previous cardiac safety analysis published ten years ago, a review of clinical trials published during the last 10 years as well as single-case descriptions related to trabectedin cardiotoxicity. The estimated incidence of cardiac toxicity was 3,4% among patients receiving trabectedin, with recent data suggesting a higher rate of heart failure than previously recognized. Previous or concomitant anthracyclines exposure may represent a risk factor. Assaying for NT-pro-BNP may be useful for the early detection of individuals with trabectedin-induced heart failure.
format	article
author	Julien Catherine Christiane Jungels Valerie Durieux Valerie Durieux Coralie Deliens Bogdan Grigoriu
author_facet	Julien Catherine Christiane Jungels Valerie Durieux Valerie Durieux Coralie Deliens Bogdan Grigoriu
author_sort	Julien Catherine
title	Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature
title_short	Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature
title_full	Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature
title_fullStr	Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature
title_full_unstemmed	Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature
title_sort	trabectedin-related heart failure: case report and a systematic review of the literature
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/319c91c1a88040b99fa91a6f2b98a8ad
work_keys_str_mv	AT juliencatherine trabectedinrelatedheartfailurecasereportandasystematicreviewoftheliterature AT christianejungels trabectedinrelatedheartfailurecasereportandasystematicreviewoftheliterature AT valeriedurieux trabectedinrelatedheartfailurecasereportandasystematicreviewoftheliterature AT valeriedurieux trabectedinrelatedheartfailurecasereportandasystematicreviewoftheliterature AT coraliedeliens trabectedinrelatedheartfailurecasereportandasystematicreviewoftheliterature AT bogdangrigoriu trabectedinrelatedheartfailurecasereportandasystematicreviewoftheliterature
_version_	1718424965803409408

Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature

Ejemplares similares