Brain amyloid β protein and memory disruption in Alzheimer’s disease
Weiming XiaCenter for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USAAbstract: The development of amyloid-containing neuritic plaques is an invariable characteristic of Alzheimer’s diseases (AD). The c...
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Dove Medical Press
2010
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oai:doaj.org-article:319cf29a66cc4c8fb0a26688ef7a724f2021-12-02T03:13:09ZBrain amyloid β protein and memory disruption in Alzheimer’s disease1176-63281178-2021https://doaj.org/article/319cf29a66cc4c8fb0a26688ef7a724f2010-09-01T00:00:00Zhttp://www.dovepress.com/brain-amyloid-szlig-protein-and-memory-disruption-in-alzheimerrsquos-d-a5236https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Weiming XiaCenter for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USAAbstract: The development of amyloid-containing neuritic plaques is an invariable characteristic of Alzheimer’s diseases (AD). The conversion from monomeric amyloid β protein (Aβ) to oligomeric Aβ and finally neuritic plaques is highly dynamic. The specific Aß species that is correlated with disease severity remains to be discovered. Oligomeric Aβ has been detected in cultured cells, rodent and human brains, as well as human cerebrospinal fluid. Synthetic, cell, and brain derived Aβ oligomers have been found to inhibit hippocampal long-term potentiation (LTP) and this effect can be suppressed by the blockage of Aβ oligomer formation. A large body of evidence suggests that Aβ oligomers inhibit N-methyl-D-aspartate receptor dependent LTP; additional receptors have also been found to elicit downstream pathways upon binding to Aβ oligomers. Amyloid antibodies and small molecular compounds that reduce brain Aβ levels and block Aβ oligomer formation are capable of reversing synaptic dysfunction and these approaches hold a promising therapeutic potential to rescue memory disruption.Keywords: Alzheimer, amyloid, oligomer, long-term potentiation, NMDA Weiming XiaDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 605-612 (2010) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Weiming Xia Brain amyloid β protein and memory disruption in Alzheimer’s disease |
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Weiming XiaCenter for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USAAbstract: The development of amyloid-containing neuritic plaques is an invariable characteristic of Alzheimer’s diseases (AD). The conversion from monomeric amyloid β protein (Aβ) to oligomeric Aβ and finally neuritic plaques is highly dynamic. The specific Aß species that is correlated with disease severity remains to be discovered. Oligomeric Aβ has been detected in cultured cells, rodent and human brains, as well as human cerebrospinal fluid. Synthetic, cell, and brain derived Aβ oligomers have been found to inhibit hippocampal long-term potentiation (LTP) and this effect can be suppressed by the blockage of Aβ oligomer formation. A large body of evidence suggests that Aβ oligomers inhibit N-methyl-D-aspartate receptor dependent LTP; additional receptors have also been found to elicit downstream pathways upon binding to Aβ oligomers. Amyloid antibodies and small molecular compounds that reduce brain Aβ levels and block Aβ oligomer formation are capable of reversing synaptic dysfunction and these approaches hold a promising therapeutic potential to rescue memory disruption.Keywords: Alzheimer, amyloid, oligomer, long-term potentiation, NMDA |
format |
article |
author |
Weiming Xia |
author_facet |
Weiming Xia |
author_sort |
Weiming Xia |
title |
Brain amyloid β protein and memory disruption in Alzheimer’s disease |
title_short |
Brain amyloid β protein and memory disruption in Alzheimer’s disease |
title_full |
Brain amyloid β protein and memory disruption in Alzheimer’s disease |
title_fullStr |
Brain amyloid β protein and memory disruption in Alzheimer’s disease |
title_full_unstemmed |
Brain amyloid β protein and memory disruption in Alzheimer’s disease |
title_sort |
brain amyloid β protein and memory disruption in alzheimer’s disease |
publisher |
Dove Medical Press |
publishDate |
2010 |
url |
https://doaj.org/article/319cf29a66cc4c8fb0a26688ef7a724f |
work_keys_str_mv |
AT weimingxia brainamyloidampbetaproteinandmemorydisruptioninalzheimeramprsquosdisease |
_version_ |
1718401844585168896 |