Spatial competition constrains resistance to targeted cancer therapy

Adaptive therapy aims to control tumours by exploiting competition between therapy-sensitive and resistant cells. Here, the authors show that tumour spatial structure is a critical parameter for adaptive therapy as competition for space increases fitness differentials, allowing suppression of resist...

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Autores principales:	Katarina Bacevic, Robert Noble, Ahmed Soffar, Orchid Wael Ammar, Benjamin Boszonyik, Susana Prieto, Charles Vincent, Michael E. Hochberg, Liliana Krasinska, Daniel Fisher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/319e6d8db9064cf9bdccfcfa5db86330
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spelling	oai:doaj.org-article:319e6d8db9064cf9bdccfcfa5db863302021-12-02T17:01:23ZSpatial competition constrains resistance to targeted cancer therapy10.1038/s41467-017-01516-12041-1723https://doaj.org/article/319e6d8db9064cf9bdccfcfa5db863302017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01516-1https://doaj.org/toc/2041-1723Adaptive therapy aims to control tumours by exploiting competition between therapy-sensitive and resistant cells. Here, the authors show that tumour spatial structure is a critical parameter for adaptive therapy as competition for space increases fitness differentials, allowing suppression of resistance with low-dose treatments.Katarina BacevicRobert NobleAhmed SoffarOrchid Wael AmmarBenjamin BoszonyikSusana PrietoCharles VincentMichael E. HochbergLiliana KrasinskaDaniel FisherNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katarina Bacevic Robert Noble Ahmed Soffar Orchid Wael Ammar Benjamin Boszonyik Susana Prieto Charles Vincent Michael E. Hochberg Liliana Krasinska Daniel Fisher Spatial competition constrains resistance to targeted cancer therapy
description	Adaptive therapy aims to control tumours by exploiting competition between therapy-sensitive and resistant cells. Here, the authors show that tumour spatial structure is a critical parameter for adaptive therapy as competition for space increases fitness differentials, allowing suppression of resistance with low-dose treatments.
format	article
author	Katarina Bacevic Robert Noble Ahmed Soffar Orchid Wael Ammar Benjamin Boszonyik Susana Prieto Charles Vincent Michael E. Hochberg Liliana Krasinska Daniel Fisher
author_facet	Katarina Bacevic Robert Noble Ahmed Soffar Orchid Wael Ammar Benjamin Boszonyik Susana Prieto Charles Vincent Michael E. Hochberg Liliana Krasinska Daniel Fisher
author_sort	Katarina Bacevic
title	Spatial competition constrains resistance to targeted cancer therapy
title_short	Spatial competition constrains resistance to targeted cancer therapy
title_full	Spatial competition constrains resistance to targeted cancer therapy
title_fullStr	Spatial competition constrains resistance to targeted cancer therapy
title_full_unstemmed	Spatial competition constrains resistance to targeted cancer therapy
title_sort	spatial competition constrains resistance to targeted cancer therapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/319e6d8db9064cf9bdccfcfa5db86330
work_keys_str_mv	AT katarinabacevic spatialcompetitionconstrainsresistancetotargetedcancertherapy AT robertnoble spatialcompetitionconstrainsresistancetotargetedcancertherapy AT ahmedsoffar spatialcompetitionconstrainsresistancetotargetedcancertherapy AT orchidwaelammar spatialcompetitionconstrainsresistancetotargetedcancertherapy AT benjaminboszonyik spatialcompetitionconstrainsresistancetotargetedcancertherapy AT susanaprieto spatialcompetitionconstrainsresistancetotargetedcancertherapy AT charlesvincent spatialcompetitionconstrainsresistancetotargetedcancertherapy AT michaelehochberg spatialcompetitionconstrainsresistancetotargetedcancertherapy AT lilianakrasinska spatialcompetitionconstrainsresistancetotargetedcancertherapy AT danielfisher spatialcompetitionconstrainsresistancetotargetedcancertherapy
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Spatial competition constrains resistance to targeted cancer therapy

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