Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena

Abstract Nodularia spumigena is a bloom-forming diazotrophic cyanobacterium inhabiting brackish waters worldwide. This species produces non-ribosomal peptides (NRPs), including the hepatotoxin nodularin, often referred to as cyanotoxin. Several known classes of NRPs have various biological activitie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sandra Lage, Hanna Mazur-Marzec, Elena Gorokhova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/319eff2a17ac4df48221fa5022d06325
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:319eff2a17ac4df48221fa5022d06325
record_format	dspace
spelling	oai:doaj.org-article:319eff2a17ac4df48221fa5022d063252021-12-02T16:56:10ZCompetitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena10.1038/s41598-021-88361-x2045-2322https://doaj.org/article/319eff2a17ac4df48221fa5022d063252021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88361-xhttps://doaj.org/toc/2045-2322Abstract Nodularia spumigena is a bloom-forming diazotrophic cyanobacterium inhabiting brackish waters worldwide. This species produces non-ribosomal peptides (NRPs), including the hepatotoxin nodularin, often referred to as cyanotoxin. Several known classes of NRPs have various biological activities, although their modes of action are poorly understood. In the Baltic N. spumigena, there is a high NRP chemodiversity among strains, allowing their grouping in specific chemotypes and subgroups. Therefore, it is relevant to ask whether the NRP production is affected by intraspecific interactions between the co-existing strains. Using a novel approach that combines culture technique and liquid chromatography-tandem mass spectrometry for the NRP analysis, we examined N. spumigena strains under mono- and co-culture conditions. The test strains were selected to represent N. spumigena belonging to the same or different chemotype subgroups. In this setup, we observed physiological and metabolic responses in the test strains grown without cell contact. The changes in NRP levels to co-culture conditions were conserved within a chemotype subgroup but different between the subgroups. Our results suggest that intraspecific interactions may promote a chemical diversity in N. spumigena population, with higher NRP production compared to a single-strain population. Studying allelochemical signalling in this cyanobacterium is crucial for understanding toxicity mechanisms and plankton community interactions in the Baltic Sea and other aquatic systems experiencing regular blooms.Sandra LageHanna Mazur-MarzecElena GorokhovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandra Lage Hanna Mazur-Marzec Elena Gorokhova Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena
description	Abstract Nodularia spumigena is a bloom-forming diazotrophic cyanobacterium inhabiting brackish waters worldwide. This species produces non-ribosomal peptides (NRPs), including the hepatotoxin nodularin, often referred to as cyanotoxin. Several known classes of NRPs have various biological activities, although their modes of action are poorly understood. In the Baltic N. spumigena, there is a high NRP chemodiversity among strains, allowing their grouping in specific chemotypes and subgroups. Therefore, it is relevant to ask whether the NRP production is affected by intraspecific interactions between the co-existing strains. Using a novel approach that combines culture technique and liquid chromatography-tandem mass spectrometry for the NRP analysis, we examined N. spumigena strains under mono- and co-culture conditions. The test strains were selected to represent N. spumigena belonging to the same or different chemotype subgroups. In this setup, we observed physiological and metabolic responses in the test strains grown without cell contact. The changes in NRP levels to co-culture conditions were conserved within a chemotype subgroup but different between the subgroups. Our results suggest that intraspecific interactions may promote a chemical diversity in N. spumigena population, with higher NRP production compared to a single-strain population. Studying allelochemical signalling in this cyanobacterium is crucial for understanding toxicity mechanisms and plankton community interactions in the Baltic Sea and other aquatic systems experiencing regular blooms.
format	article
author	Sandra Lage Hanna Mazur-Marzec Elena Gorokhova
author_facet	Sandra Lage Hanna Mazur-Marzec Elena Gorokhova
author_sort	Sandra Lage
title	Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena
title_short	Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena
title_full	Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena
title_fullStr	Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena
title_full_unstemmed	Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena
title_sort	competitive interactions as a mechanism for chemical diversity maintenance in nodularia spumigena
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/319eff2a17ac4df48221fa5022d06325
work_keys_str_mv	AT sandralage competitiveinteractionsasamechanismforchemicaldiversitymaintenanceinnodulariaspumigena AT hannamazurmarzec competitiveinteractionsasamechanismforchemicaldiversitymaintenanceinnodulariaspumigena AT elenagorokhova competitiveinteractionsasamechanismforchemicaldiversitymaintenanceinnodulariaspumigena
_version_	1718382791810351104

Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena

Ejemplares similares