Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A

Arisandilactone A is a natural product with a complex oxa-bridged tricyclic carbon core, making it a challenging target in total synthesis. Here the authors report an asymmetric total synthesis of its 19-dehydroxy derivative, with homo-Michael and tandem retro-Michael/Michael reactions as key steps.

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Autores principales: Yi-Xin Han, Yan-Long Jiang, Yong Li, Hai-Xin Yu, Bing-Qi Tong, Zhe Niu, Shi-Jie Zhou, Song Liu, Yu Lan, Jia-Hua Chen, Zhen Yang
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/319f43e19f6445e4882a30aa1bd31420
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spelling oai:doaj.org-article:319f43e19f6445e4882a30aa1bd314202021-12-02T15:37:03ZBiomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A10.1038/ncomms142332041-1723https://doaj.org/article/319f43e19f6445e4882a30aa1bd314202017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14233https://doaj.org/toc/2041-1723Arisandilactone A is a natural product with a complex oxa-bridged tricyclic carbon core, making it a challenging target in total synthesis. Here the authors report an asymmetric total synthesis of its 19-dehydroxy derivative, with homo-Michael and tandem retro-Michael/Michael reactions as key steps.Yi-Xin HanYan-Long JiangYong LiHai-Xin YuBing-Qi TongZhe NiuShi-Jie ZhouSong LiuYu LanJia-Hua ChenZhen YangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yi-Xin Han
Yan-Long Jiang
Yong Li
Hai-Xin Yu
Bing-Qi Tong
Zhe Niu
Shi-Jie Zhou
Song Liu
Yu Lan
Jia-Hua Chen
Zhen Yang
Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A
description Arisandilactone A is a natural product with a complex oxa-bridged tricyclic carbon core, making it a challenging target in total synthesis. Here the authors report an asymmetric total synthesis of its 19-dehydroxy derivative, with homo-Michael and tandem retro-Michael/Michael reactions as key steps.
format article
author Yi-Xin Han
Yan-Long Jiang
Yong Li
Hai-Xin Yu
Bing-Qi Tong
Zhe Niu
Shi-Jie Zhou
Song Liu
Yu Lan
Jia-Hua Chen
Zhen Yang
author_facet Yi-Xin Han
Yan-Long Jiang
Yong Li
Hai-Xin Yu
Bing-Qi Tong
Zhe Niu
Shi-Jie Zhou
Song Liu
Yu Lan
Jia-Hua Chen
Zhen Yang
author_sort Yi-Xin Han
title Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A
title_short Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A
title_full Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A
title_fullStr Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A
title_full_unstemmed Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A
title_sort biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone a
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/319f43e19f6445e4882a30aa1bd31420
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