MURC deficiency in smooth muscle attenuates pulmonary hypertension

MURC protein regulates the function of caveolae, the small invaginations of the plasma membrane in muscle cells. Here the authors show that by interacting with caveolin proteins, MURC affects RhoA/ROCK signalling and regulates proliferation and migration of pulmonary artery smooth muscle cells, sugg...

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Autores principales:	Naohiko Nakanishi, Takehiro Ogata, Daisuke Naito, Kotaro Miyagawa, Takuya Taniguchi, Tetsuro Hamaoka, Naoki Maruyama, Takeru Kasahara, Masahiro Nishi, Satoaki Matoba, Tomomi Ueyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/319f57afca5f405fb6cd95e83c7e27fc
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spelling	oai:doaj.org-article:319f57afca5f405fb6cd95e83c7e27fc2021-12-02T15:34:32ZMURC deficiency in smooth muscle attenuates pulmonary hypertension10.1038/ncomms124172041-1723https://doaj.org/article/319f57afca5f405fb6cd95e83c7e27fc2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12417https://doaj.org/toc/2041-1723MURC protein regulates the function of caveolae, the small invaginations of the plasma membrane in muscle cells. Here the authors show that by interacting with caveolin proteins, MURC affects RhoA/ROCK signalling and regulates proliferation and migration of pulmonary artery smooth muscle cells, suggesting a new target in therapy of pulmonary hypertension.Naohiko NakanishiTakehiro OgataDaisuke NaitoKotaro MiyagawaTakuya TaniguchiTetsuro HamaokaNaoki MaruyamaTakeru KasaharaMasahiro NishiSatoaki MatobaTomomi UeyamaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naohiko Nakanishi Takehiro Ogata Daisuke Naito Kotaro Miyagawa Takuya Taniguchi Tetsuro Hamaoka Naoki Maruyama Takeru Kasahara Masahiro Nishi Satoaki Matoba Tomomi Ueyama MURC deficiency in smooth muscle attenuates pulmonary hypertension
description	MURC protein regulates the function of caveolae, the small invaginations of the plasma membrane in muscle cells. Here the authors show that by interacting with caveolin proteins, MURC affects RhoA/ROCK signalling and regulates proliferation and migration of pulmonary artery smooth muscle cells, suggesting a new target in therapy of pulmonary hypertension.
format	article
author	Naohiko Nakanishi Takehiro Ogata Daisuke Naito Kotaro Miyagawa Takuya Taniguchi Tetsuro Hamaoka Naoki Maruyama Takeru Kasahara Masahiro Nishi Satoaki Matoba Tomomi Ueyama
author_facet	Naohiko Nakanishi Takehiro Ogata Daisuke Naito Kotaro Miyagawa Takuya Taniguchi Tetsuro Hamaoka Naoki Maruyama Takeru Kasahara Masahiro Nishi Satoaki Matoba Tomomi Ueyama
author_sort	Naohiko Nakanishi
title	MURC deficiency in smooth muscle attenuates pulmonary hypertension
title_short	MURC deficiency in smooth muscle attenuates pulmonary hypertension
title_full	MURC deficiency in smooth muscle attenuates pulmonary hypertension
title_fullStr	MURC deficiency in smooth muscle attenuates pulmonary hypertension
title_full_unstemmed	MURC deficiency in smooth muscle attenuates pulmonary hypertension
title_sort	murc deficiency in smooth muscle attenuates pulmonary hypertension
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/319f57afca5f405fb6cd95e83c7e27fc
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MURC deficiency in smooth muscle attenuates pulmonary hypertension

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