Somatostatin Receptors in Human Meningiomas—Clinicopathological Aspects

Meningiomas have high recurrence rates despite frequently benign histopathological appearances. Somatostatin receptors (SSTRs) may be reliable biomarkers that could identify patients with increased risk of recurrence. Even though SSTRs are previously detected in meningiomas, their associations to cl...

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Autores principales:	Sofie Eline Tollefsen, Anders H. Jarmund, Borgny Ytterhus, Øyvind Salvesen, Patricia Mjønes, Sverre Helge Torp
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	brain tumors meningioma immunohistochemistry somatostatin receptors SSTR digital pathology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/319f7d22fac544da8b862a156dc93024
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spelling	oai:doaj.org-article:319f7d22fac544da8b862a156dc930242021-11-25T17:02:52ZSomatostatin Receptors in Human Meningiomas—Clinicopathological Aspects10.3390/cancers132257042072-6694https://doaj.org/article/319f7d22fac544da8b862a156dc930242021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5704https://doaj.org/toc/2072-6694Meningiomas have high recurrence rates despite frequently benign histopathological appearances. Somatostatin receptors (SSTRs) may be reliable biomarkers that could identify patients with increased risk of recurrence. Even though SSTRs are previously detected in meningiomas, their associations to clinicopathological features remain unclear. The aim of this study was to investigate the diagnostic and prognostic value of SSTRs in a large series of human meningiomas with long follow-up data. Immunohistochemistry was used to measure the expression of SSTR1-SSTR5 in tissue samples from 162 patients diagnosed with intracranial meningiomas of World Health Organization (WHO) grade 1 or 2. Digital scoring and a manual staining index were applied to assess immunoreactivity. All SSTRs, except SSTR4, were upregulated in our series of meningiomas. SSTR1 (<i>p</i> = 0.036), SSTR2 (<i>p</i> = 0.036) and SSTR5 (<i>p</i> = 0.029) were associated with a higher malignancy grade. SSTR2 presented as the most reliable marker. Only SSTR2 was associated with time to recurrence (TTR) in univariate Cox regression analyses. Manual staining index was strongly correlated with digital scoring for all SSTRs (<i>r</i> > 0.65, <i>p</i> < 0.001). SSTRs, and especially SSTR2, are useful in the diagnostics of meningiomas, even though their prognostic value appears limited. Digital scoring is valuable to ensure reproducibility.Sofie Eline TollefsenAnders H. JarmundBorgny YtterhusØyvind SalvesenPatricia MjønesSverre Helge TorpMDPI AGarticlebrain tumorsmeningiomaimmunohistochemistrysomatostatin receptorsSSTRdigital pathologyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5704, p 5704 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain tumors meningioma immunohistochemistry somatostatin receptors SSTR digital pathology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	brain tumors meningioma immunohistochemistry somatostatin receptors SSTR digital pathology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sofie Eline Tollefsen Anders H. Jarmund Borgny Ytterhus Øyvind Salvesen Patricia Mjønes Sverre Helge Torp Somatostatin Receptors in Human Meningiomas—Clinicopathological Aspects
description	Meningiomas have high recurrence rates despite frequently benign histopathological appearances. Somatostatin receptors (SSTRs) may be reliable biomarkers that could identify patients with increased risk of recurrence. Even though SSTRs are previously detected in meningiomas, their associations to clinicopathological features remain unclear. The aim of this study was to investigate the diagnostic and prognostic value of SSTRs in a large series of human meningiomas with long follow-up data. Immunohistochemistry was used to measure the expression of SSTR1-SSTR5 in tissue samples from 162 patients diagnosed with intracranial meningiomas of World Health Organization (WHO) grade 1 or 2. Digital scoring and a manual staining index were applied to assess immunoreactivity. All SSTRs, except SSTR4, were upregulated in our series of meningiomas. SSTR1 (<i>p</i> = 0.036), SSTR2 (<i>p</i> = 0.036) and SSTR5 (<i>p</i> = 0.029) were associated with a higher malignancy grade. SSTR2 presented as the most reliable marker. Only SSTR2 was associated with time to recurrence (TTR) in univariate Cox regression analyses. Manual staining index was strongly correlated with digital scoring for all SSTRs (<i>r</i> > 0.65, <i>p</i> < 0.001). SSTRs, and especially SSTR2, are useful in the diagnostics of meningiomas, even though their prognostic value appears limited. Digital scoring is valuable to ensure reproducibility.
format	article
author	Sofie Eline Tollefsen Anders H. Jarmund Borgny Ytterhus Øyvind Salvesen Patricia Mjønes Sverre Helge Torp
author_facet	Sofie Eline Tollefsen Anders H. Jarmund Borgny Ytterhus Øyvind Salvesen Patricia Mjønes Sverre Helge Torp
author_sort	Sofie Eline Tollefsen
title	Somatostatin Receptors in Human Meningiomas—Clinicopathological Aspects
title_short	Somatostatin Receptors in Human Meningiomas—Clinicopathological Aspects
title_full	Somatostatin Receptors in Human Meningiomas—Clinicopathological Aspects
title_fullStr	Somatostatin Receptors in Human Meningiomas—Clinicopathological Aspects
title_full_unstemmed	Somatostatin Receptors in Human Meningiomas—Clinicopathological Aspects
title_sort	somatostatin receptors in human meningiomas—clinicopathological aspects
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/319f7d22fac544da8b862a156dc93024
work_keys_str_mv	AT sofieelinetollefsen somatostatinreceptorsinhumanmeningiomasclinicopathologicalaspects AT andershjarmund somatostatinreceptorsinhumanmeningiomasclinicopathologicalaspects AT borgnyytterhus somatostatinreceptorsinhumanmeningiomasclinicopathologicalaspects AT øyvindsalvesen somatostatinreceptorsinhumanmeningiomasclinicopathologicalaspects AT patriciamjønes somatostatinreceptorsinhumanmeningiomasclinicopathologicalaspects AT sverrehelgetorp somatostatinreceptorsinhumanmeningiomasclinicopathologicalaspects
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Somatostatin Receptors in Human Meningiomas—Clinicopathological Aspects

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