The Glucocorticoid PYED-1 Disrupts Mature Biofilms of Candida spp. and Inhibits Hyphal Development in Candida albicans

Invasive Candida infections have become a global public health problem due to the increase of Candida species resistant against antifungal therapeutics. The glucocorticoid PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) has antimicrobial activity agai...

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Autores principales:	Anna Esposito, Antonella Migliaccio, Vita Dora Iula, Raffaele Zarrilli, Annalisa Guaragna, Eliana De Gregorio
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glucocorticoid antifungal agents anti-biofilm agents <i>Candida</i> spp. Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/31a1303f997247b89aec2c87c4219a2a
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spelling	oai:doaj.org-article:31a1303f997247b89aec2c87c4219a2a2021-11-25T16:24:40ZThe Glucocorticoid PYED-1 Disrupts Mature Biofilms of <i>Candida</i> spp. and Inhibits Hyphal Development in <i>Candida albicans</i>10.3390/antibiotics101113962079-6382https://doaj.org/article/31a1303f997247b89aec2c87c4219a2a2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1396https://doaj.org/toc/2079-6382Invasive <i>Candida</i> infections have become a global public health problem due to the increase of <i>Candida</i> species resistant against antifungal therapeutics. The glucocorticoid PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) has antimicrobial activity against various bacterial taxa. Consequently, it might be considered for the treatment of <i>Candida</i> infections. The antifungal activity of PYED-1 was evaluated against several fungal strains that were representative of the five species that causes the majority of <i>Candida</i> infections—namely, <i>Candida albicans</i>, <i>Candida glabrata</i>, <i>Candida tropicalis</i>, <i>Candida parapsilosis</i> and <i>Candida krusei</i>. PYED-1 exhibited a weak antifungal activity and a fungistatic effect on all five <i>Candida</i> species. On the other hand, PYED-1 exhibited a good anti-biofilm activity, and was able to eradicate the preformed biofilms of all <i>Candida</i> species analyzed. Moreover, PYED-1 inhibited germ tube and hyphae formation of <i>C. albicans</i> and reduced adhesion of <i>C. albicans</i> to abiotic surfaces by up to 30%.Anna EspositoAntonella MigliaccioVita Dora IulaRaffaele ZarrilliAnnalisa GuaragnaEliana De GregorioMDPI AGarticleglucocorticoidantifungal agentsanti-biofilm agents<i>Candida</i> spp.Therapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1396, p 1396 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glucocorticoid antifungal agents anti-biofilm agents <i>Candida</i> spp. Therapeutics. Pharmacology RM1-950
spellingShingle	glucocorticoid antifungal agents anti-biofilm agents <i>Candida</i> spp. Therapeutics. Pharmacology RM1-950 Anna Esposito Antonella Migliaccio Vita Dora Iula Raffaele Zarrilli Annalisa Guaragna Eliana De Gregorio The Glucocorticoid PYED-1 Disrupts Mature Biofilms of <i>Candida</i> spp. and Inhibits Hyphal Development in <i>Candida albicans</i>
description	Invasive <i>Candida</i> infections have become a global public health problem due to the increase of <i>Candida</i> species resistant against antifungal therapeutics. The glucocorticoid PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) has antimicrobial activity against various bacterial taxa. Consequently, it might be considered for the treatment of <i>Candida</i> infections. The antifungal activity of PYED-1 was evaluated against several fungal strains that were representative of the five species that causes the majority of <i>Candida</i> infections—namely, <i>Candida albicans</i>, <i>Candida glabrata</i>, <i>Candida tropicalis</i>, <i>Candida parapsilosis</i> and <i>Candida krusei</i>. PYED-1 exhibited a weak antifungal activity and a fungistatic effect on all five <i>Candida</i> species. On the other hand, PYED-1 exhibited a good anti-biofilm activity, and was able to eradicate the preformed biofilms of all <i>Candida</i> species analyzed. Moreover, PYED-1 inhibited germ tube and hyphae formation of <i>C. albicans</i> and reduced adhesion of <i>C. albicans</i> to abiotic surfaces by up to 30%.
format	article
author	Anna Esposito Antonella Migliaccio Vita Dora Iula Raffaele Zarrilli Annalisa Guaragna Eliana De Gregorio
author_facet	Anna Esposito Antonella Migliaccio Vita Dora Iula Raffaele Zarrilli Annalisa Guaragna Eliana De Gregorio
author_sort	Anna Esposito
title	The Glucocorticoid PYED-1 Disrupts Mature Biofilms of <i>Candida</i> spp. and Inhibits Hyphal Development in <i>Candida albicans</i>
title_short	The Glucocorticoid PYED-1 Disrupts Mature Biofilms of <i>Candida</i> spp. and Inhibits Hyphal Development in <i>Candida albicans</i>
title_full	The Glucocorticoid PYED-1 Disrupts Mature Biofilms of <i>Candida</i> spp. and Inhibits Hyphal Development in <i>Candida albicans</i>
title_fullStr	The Glucocorticoid PYED-1 Disrupts Mature Biofilms of <i>Candida</i> spp. and Inhibits Hyphal Development in <i>Candida albicans</i>
title_full_unstemmed	The Glucocorticoid PYED-1 Disrupts Mature Biofilms of <i>Candida</i> spp. and Inhibits Hyphal Development in <i>Candida albicans</i>
title_sort	glucocorticoid pyed-1 disrupts mature biofilms of <i>candida</i> spp. and inhibits hyphal development in <i>candida albicans</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/31a1303f997247b89aec2c87c4219a2a
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The Glucocorticoid PYED-1 Disrupts Mature Biofilms of <i>Candida</i> spp. and Inhibits Hyphal Development in <i>Candida albicans</i>

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