Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
The BTK inhibitor ibrutinib is used to treat chronic lymphocytic leukaemia, however some patients develop resistance to the drug. Here, the authors use genomic analyses to examine the clonal evolution of 5 patients that develop resistance to ibrutinib.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/31a1991cd4d64583af26755ec24a7d52 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:31a1991cd4d64583af26755ec24a7d52 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:31a1991cd4d64583af26755ec24a7d522021-12-02T16:49:27ZClonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition10.1038/ncomms115892041-1723https://doaj.org/article/31a1991cd4d64583af26755ec24a7d522016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11589https://doaj.org/toc/2041-1723The BTK inhibitor ibrutinib is used to treat chronic lymphocytic leukaemia, however some patients develop resistance to the drug. Here, the authors use genomic analyses to examine the clonal evolution of 5 patients that develop resistance to ibrutinib.Jan A. BurgerDan A. LandauAmaro Taylor-WeinerIvana BozicHuidan ZhangKristopher SarosiekLili WangChip StewartJean FanJulia HoellenriegelMariela SivinaAdrian M. DubucCameron FraserYulong HanShuqiang LiKenneth J. LivakLihua ZouYouzhong WanSergej KonoplevCarrie SougnezJennifer R. BrownLynne V. AbruzzoScott L. CarterMichael J. KeatingMatthew S. DavidsWilliam G. WierdaKristian CibulskisThorsten ZenzLillian WernerPaola Dal CinPeter KharchenckoDonna NeubergHagop KantarjianEric LanderStacey GabrielSusan O’BrienAnthony LetaiDavid A. WeitzMartin A. NowakGad GetzCatherine J. WuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jan A. Burger Dan A. Landau Amaro Taylor-Weiner Ivana Bozic Huidan Zhang Kristopher Sarosiek Lili Wang Chip Stewart Jean Fan Julia Hoellenriegel Mariela Sivina Adrian M. Dubuc Cameron Fraser Yulong Han Shuqiang Li Kenneth J. Livak Lihua Zou Youzhong Wan Sergej Konoplev Carrie Sougnez Jennifer R. Brown Lynne V. Abruzzo Scott L. Carter Michael J. Keating Matthew S. Davids William G. Wierda Kristian Cibulskis Thorsten Zenz Lillian Werner Paola Dal Cin Peter Kharchencko Donna Neuberg Hagop Kantarjian Eric Lander Stacey Gabriel Susan O’Brien Anthony Letai David A. Weitz Martin A. Nowak Gad Getz Catherine J. Wu Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition |
| description |
The BTK inhibitor ibrutinib is used to treat chronic lymphocytic leukaemia, however some patients develop resistance to the drug. Here, the authors use genomic analyses to examine the clonal evolution of 5 patients that develop resistance to ibrutinib. |
| format |
article |
| author |
Jan A. Burger Dan A. Landau Amaro Taylor-Weiner Ivana Bozic Huidan Zhang Kristopher Sarosiek Lili Wang Chip Stewart Jean Fan Julia Hoellenriegel Mariela Sivina Adrian M. Dubuc Cameron Fraser Yulong Han Shuqiang Li Kenneth J. Livak Lihua Zou Youzhong Wan Sergej Konoplev Carrie Sougnez Jennifer R. Brown Lynne V. Abruzzo Scott L. Carter Michael J. Keating Matthew S. Davids William G. Wierda Kristian Cibulskis Thorsten Zenz Lillian Werner Paola Dal Cin Peter Kharchencko Donna Neuberg Hagop Kantarjian Eric Lander Stacey Gabriel Susan O’Brien Anthony Letai David A. Weitz Martin A. Nowak Gad Getz Catherine J. Wu |
| author_facet |
Jan A. Burger Dan A. Landau Amaro Taylor-Weiner Ivana Bozic Huidan Zhang Kristopher Sarosiek Lili Wang Chip Stewart Jean Fan Julia Hoellenriegel Mariela Sivina Adrian M. Dubuc Cameron Fraser Yulong Han Shuqiang Li Kenneth J. Livak Lihua Zou Youzhong Wan Sergej Konoplev Carrie Sougnez Jennifer R. Brown Lynne V. Abruzzo Scott L. Carter Michael J. Keating Matthew S. Davids William G. Wierda Kristian Cibulskis Thorsten Zenz Lillian Werner Paola Dal Cin Peter Kharchencko Donna Neuberg Hagop Kantarjian Eric Lander Stacey Gabriel Susan O’Brien Anthony Letai David A. Weitz Martin A. Nowak Gad Getz Catherine J. Wu |
| author_sort |
Jan A. Burger |
| title |
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition |
| title_short |
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition |
| title_full |
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition |
| title_fullStr |
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition |
| title_full_unstemmed |
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition |
| title_sort |
clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to btk inhibition |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/31a1991cd4d64583af26755ec24a7d52 |
| work_keys_str_mv |
AT janaburger clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT danalandau clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT amarotaylorweiner clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT ivanabozic clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT huidanzhang clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT kristophersarosiek clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT liliwang clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT chipstewart clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT jeanfan clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT juliahoellenriegel clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT marielasivina clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT adrianmdubuc clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT cameronfraser clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT yulonghan clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT shuqiangli clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT kennethjlivak clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT lihuazou clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT youzhongwan clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT sergejkonoplev clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT carriesougnez clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT jenniferrbrown clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT lynnevabruzzo clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT scottlcarter clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT michaeljkeating clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT matthewsdavids clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT williamgwierda clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT kristiancibulskis clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT thorstenzenz clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT lillianwerner clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT paoladalcin clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT peterkharchencko clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT donnaneuberg clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT hagopkantarjian clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT ericlander clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT staceygabriel clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT susanobrien clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT anthonyletai clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT davidaweitz clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT martinanowak clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT gadgetz clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition AT catherinejwu clonalevolutioninpatientswithchroniclymphocyticleukaemiadevelopingresistancetobtkinhibition |
| _version_ |
1718383326107009024 |