Miz1 is a critical repressor of cdkn1a during skin tumorigenesis.
The transcription factor Miz1 forms repressive DNA-binding complexes with the Myc, Gfi-1 and Bcl-6 oncoproteins. Known target genes of these complexes encode the cyclin-dependent kinase inhibitors (CKIs) cdkn2b (p15(Ink4)), cdkn1a (p21(Cip1)), and cdkn1c (p57(Kip2)). Whether Miz1-mediated repression...
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Autores principales: | Jan Hönnemann, Adrián Sanz-Moreno, Elmar Wolf, Martin Eilers, Hans-Peter Elsässer |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/31a3131ec12347d2b0d60793087004fa |
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