Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S Composites for Detection of Procalcitonin
Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO<sub>2</sub> porous nanoflowers with good photocatalytic perform...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/31a565d5d79a4a56bd64500cd4e06797 |
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| Sumario: | Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO<sub>2</sub> porous nanoflowers with good photocatalytic performance were prepared by combining hydrothermal synthesis and calcining. BiOI nanoflowers were synthesized by facile ultrasonic mixed reaction. Ag<sub>2</sub>S quantum dots were deposited on SnO<sub>2</sub>/BiOI composites by in situ growth method. The SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S composites with excellent photoelectric properties were employed as substrate material, which could provide significantly enhanced and stable signal because of the energy level matching of SnO<sub>2</sub>, BiOI and Ag<sub>2</sub>S and the good light absorption performance. Accordingly, a PEC immunosensor based on SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S was constructed by using the layered modification method to achieve high sensitivity analysis of PCT. The linear dynamic range of the detection method was 0.50 pg·mL<sup>−1</sup>~100 ng·mL<sup>−1</sup>, and the detection limit was 0.14 pg·mL<sup>−1</sup>. In addition, the designed PEC immunosensor exhibited satisfactory sensitivity, selectivity, stability and repeatability, which opened up a new avenue for the analyzation of PCT and further provided guidance for antibiotic therapy. |
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