Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO2/BiOI/Ag2S Composites for Detection of Procalcitonin

Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO2 porous nanoflowers with good photocatalytic perform...

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Autores principales:	Nuo Zhang, Jinhui Feng, Guanhui Zhao, Xiaoyi Duan, Yaoguang Wang, Daopeng Zhang, Qin Wei
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	photoelectrochemical immunosensor procalcitonin SnO<sub>2</sub> BiOI Ag<sub>2</sub>S Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/31a565d5d79a4a56bd64500cd4e06797
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spelling	oai:doaj.org-article:31a565d5d79a4a56bd64500cd4e067972021-11-25T16:55:00ZUltrasensitive Photochemical Immunosensor Based on Flowerlike SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S Composites for Detection of Procalcitonin10.3390/bios111104212079-6374https://doaj.org/article/31a565d5d79a4a56bd64500cd4e067972021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/421https://doaj.org/toc/2079-6374Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO<sub>2</sub> porous nanoflowers with good photocatalytic performance were prepared by combining hydrothermal synthesis and calcining. BiOI nanoflowers were synthesized by facile ultrasonic mixed reaction. Ag<sub>2</sub>S quantum dots were deposited on SnO<sub>2</sub>/BiOI composites by in situ growth method. The SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S composites with excellent photoelectric properties were employed as substrate material, which could provide significantly enhanced and stable signal because of the energy level matching of SnO<sub>2</sub>, BiOI and Ag<sub>2</sub>S and the good light absorption performance. Accordingly, a PEC immunosensor based on SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S was constructed by using the layered modification method to achieve high sensitivity analysis of PCT. The linear dynamic range of the detection method was 0.50 pg·mL<sup>−1</sup>~100 ng·mL<sup>−1</sup>, and the detection limit was 0.14 pg·mL<sup>−1</sup>. In addition, the designed PEC immunosensor exhibited satisfactory sensitivity, selectivity, stability and repeatability, which opened up a new avenue for the analyzation of PCT and further provided guidance for antibiotic therapy.Nuo ZhangJinhui FengGuanhui ZhaoXiaoyi DuanYaoguang WangDaopeng ZhangQin WeiMDPI AGarticlephotoelectrochemical immunosensorprocalcitoninSnO<sub>2</sub>BiOIAg<sub>2</sub>SBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 421, p 421 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	photoelectrochemical immunosensor procalcitonin SnO<sub>2</sub> BiOI Ag<sub>2</sub>S Biotechnology TP248.13-248.65
spellingShingle	photoelectrochemical immunosensor procalcitonin SnO<sub>2</sub> BiOI Ag<sub>2</sub>S Biotechnology TP248.13-248.65 Nuo Zhang Jinhui Feng Guanhui Zhao Xiaoyi Duan Yaoguang Wang Daopeng Zhang Qin Wei Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S Composites for Detection of Procalcitonin
description	Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO<sub>2</sub> porous nanoflowers with good photocatalytic performance were prepared by combining hydrothermal synthesis and calcining. BiOI nanoflowers were synthesized by facile ultrasonic mixed reaction. Ag<sub>2</sub>S quantum dots were deposited on SnO<sub>2</sub>/BiOI composites by in situ growth method. The SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S composites with excellent photoelectric properties were employed as substrate material, which could provide significantly enhanced and stable signal because of the energy level matching of SnO<sub>2</sub>, BiOI and Ag<sub>2</sub>S and the good light absorption performance. Accordingly, a PEC immunosensor based on SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S was constructed by using the layered modification method to achieve high sensitivity analysis of PCT. The linear dynamic range of the detection method was 0.50 pg·mL<sup>−1</sup>~100 ng·mL<sup>−1</sup>, and the detection limit was 0.14 pg·mL<sup>−1</sup>. In addition, the designed PEC immunosensor exhibited satisfactory sensitivity, selectivity, stability and repeatability, which opened up a new avenue for the analyzation of PCT and further provided guidance for antibiotic therapy.
format	article
author	Nuo Zhang Jinhui Feng Guanhui Zhao Xiaoyi Duan Yaoguang Wang Daopeng Zhang Qin Wei
author_facet	Nuo Zhang Jinhui Feng Guanhui Zhao Xiaoyi Duan Yaoguang Wang Daopeng Zhang Qin Wei
author_sort	Nuo Zhang
title	Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S Composites for Detection of Procalcitonin
title_short	Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S Composites for Detection of Procalcitonin
title_full	Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S Composites for Detection of Procalcitonin
title_fullStr	Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S Composites for Detection of Procalcitonin
title_full_unstemmed	Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S Composites for Detection of Procalcitonin
title_sort	ultrasensitive photochemical immunosensor based on flowerlike sno<sub>2</sub>/bioi/ag<sub>2</sub>s composites for detection of procalcitonin
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/31a565d5d79a4a56bd64500cd4e06797
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Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO<sub>2</sub>/BiOI/Ag<sub>2</sub>S Composites for Detection of Procalcitonin

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