Effects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study

Background: To employ optical coherence tomography angiography (OCTA) to evaluate the effects of hydroxychloroquine (HCQ) on the superficial capillary plexus (SCP) and deep retinal capillary plexus (DCP) in patients affected by rheumatoid arthritis (RA). Methods: Patients with recent diagnosis of “d...

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Autores principales:	Pierluigi Iacono, Stefano Da Pozzo, Alberto Bedendo, Monica Varano, Mariacristina Parravano
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	deep retinal capillary plexus optical coherence tomography angiography rheumatoid arthritis superficial retinal capillary plexus hydroxychloroquine Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/31abb9efb30947eda6e16be69224c1c1
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spelling	oai:doaj.org-article:31abb9efb30947eda6e16be69224c1c12021-11-11T14:58:43ZEffects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study10.3390/app112198372076-3417https://doaj.org/article/31abb9efb30947eda6e16be69224c1c12021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/9837https://doaj.org/toc/2076-3417Background: To employ optical coherence tomography angiography (OCTA) to evaluate the effects of hydroxychloroquine (HCQ) on the superficial capillary plexus (SCP) and deep retinal capillary plexus (DCP) in patients affected by rheumatoid arthritis (RA). Methods: Patients with recent diagnosis of “definite RA”, based on 2010 Rheumatoid Arthritis Classification Criteria, were included in a prospective, observational imaging study carried out by the G.B. Bietti Foundation between March 2019 and January 2020. Vessel density (VD) of SCP and DCP, central foveal thickness (CFT) and foveal avascular zone (FAZ) values were collected by OCTA. The primary outcome measure was the VD alteration of SCP and DCP in RA-patients after one year of HCQ treatment. Results: OCTA data analysis showed no statistically significant reduction in the mean VD of SCP and DCP, including the mean global area, central subfield, inner ring and temporal, superior, nasal, and inferior sectors, as well as in the mean CFT and FAZ areas. Conclusions: OCTA demonstrated no early change in the VD in the SCP and DCP, in RA-patients after one year of HCQ treatment. A longer monitoring period would more precisely establish the treatment’s effect on the VD and its correlation with HCQ toxicity.Pierluigi IaconoStefano Da PozzoAlberto BedendoMonica VaranoMariacristina ParravanoMDPI AGarticledeep retinal capillary plexusoptical coherence tomography angiographyrheumatoid arthritissuperficial retinal capillary plexushydroxychloroquineTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 9837, p 9837 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	deep retinal capillary plexus optical coherence tomography angiography rheumatoid arthritis superficial retinal capillary plexus hydroxychloroquine Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	deep retinal capillary plexus optical coherence tomography angiography rheumatoid arthritis superficial retinal capillary plexus hydroxychloroquine Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Pierluigi Iacono Stefano Da Pozzo Alberto Bedendo Monica Varano Mariacristina Parravano Effects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study
description	Background: To employ optical coherence tomography angiography (OCTA) to evaluate the effects of hydroxychloroquine (HCQ) on the superficial capillary plexus (SCP) and deep retinal capillary plexus (DCP) in patients affected by rheumatoid arthritis (RA). Methods: Patients with recent diagnosis of “definite RA”, based on 2010 Rheumatoid Arthritis Classification Criteria, were included in a prospective, observational imaging study carried out by the G.B. Bietti Foundation between March 2019 and January 2020. Vessel density (VD) of SCP and DCP, central foveal thickness (CFT) and foveal avascular zone (FAZ) values were collected by OCTA. The primary outcome measure was the VD alteration of SCP and DCP in RA-patients after one year of HCQ treatment. Results: OCTA data analysis showed no statistically significant reduction in the mean VD of SCP and DCP, including the mean global area, central subfield, inner ring and temporal, superior, nasal, and inferior sectors, as well as in the mean CFT and FAZ areas. Conclusions: OCTA demonstrated no early change in the VD in the SCP and DCP, in RA-patients after one year of HCQ treatment. A longer monitoring period would more precisely establish the treatment’s effect on the VD and its correlation with HCQ toxicity.
format	article
author	Pierluigi Iacono Stefano Da Pozzo Alberto Bedendo Monica Varano Mariacristina Parravano
author_facet	Pierluigi Iacono Stefano Da Pozzo Alberto Bedendo Monica Varano Mariacristina Parravano
author_sort	Pierluigi Iacono
title	Effects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study
title_short	Effects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study
title_full	Effects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study
title_fullStr	Effects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study
title_full_unstemmed	Effects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study
title_sort	effects of hydroxychloroquine on retinal vessel density in patients with rheumatoid arthritis over one-year follow-up: a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/31abb9efb30947eda6e16be69224c1c1
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Effects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study

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