Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration

Abstract To investigate sensitive outcome measures based exclusively on abnormal points in microperimetry testing of eyes with intermediate age-related macular degeneration (iAMD). 25 eyes of 25 subjects with iAMD had undergone 2 successive tests of mesopic microperimetry with the Macular Integrity...

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Autores principales:	Yaniv Barkana, Susanne G. Pondorfer, Steffen Schmitz-Valckenberg, Hermann Russ, Robert P. Finger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31ae2287517941dd8e27401ec84c95a9
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spelling	oai:doaj.org-article:31ae2287517941dd8e27401ec84c95a92021-12-02T13:35:04ZImproved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration10.1038/s41598-021-83716-w2045-2322https://doaj.org/article/31ae2287517941dd8e27401ec84c95a92021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83716-whttps://doaj.org/toc/2045-2322Abstract To investigate sensitive outcome measures based exclusively on abnormal points in microperimetry testing of eyes with intermediate age-related macular degeneration (iAMD). 25 eyes of 25 subjects with iAMD had undergone 2 successive tests of mesopic microperimetry with the Macular Integrity Assessment Microperimeter (MAIA), using a custom grid of 33 points spanning the central 14 degrees of the macula. Each point was defined as abnormal if its threshold sensitivity was lower than 1.65 standard deviations (SD) (5%) or 2 SD (2.5%) than the expected threshold in healthy eyes according to the MAIA internal database. Among the 25 eyes there were 11.8 ± 9 and 8.4 ± 8.2 abnormal points at < 5% and < 2.5%, with mean deviation of thresholds from normal − 4.9 ± 1.2 dB and − 5.8 ± 1.5 dB, respectively. These deviations were greater, and their SD smaller, compared with the complete microperimetry grid, − 2.3 ± 2.0 dB. The 95% limits of agreement for average threshold between the 2 successive tests were smaller when only abnormal points were included. Analyzing only abnormal grid points yields an outcome parameter with a greater deviation from normal, a more homogenous dataset, and better test–retest variability, compared with analysis of all grid points. This parameter may thus be more sensitive to change, while moderately limiting the number of potential recruits. The proposed outcome measures should be further investigated as potential endpoints in clinical trials in iAMD.Yaniv BarkanaSusanne G. PondorferSteffen Schmitz-ValckenbergHermann RussRobert P. FingerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yaniv Barkana Susanne G. Pondorfer Steffen Schmitz-Valckenberg Hermann Russ Robert P. Finger Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration
description	Abstract To investigate sensitive outcome measures based exclusively on abnormal points in microperimetry testing of eyes with intermediate age-related macular degeneration (iAMD). 25 eyes of 25 subjects with iAMD had undergone 2 successive tests of mesopic microperimetry with the Macular Integrity Assessment Microperimeter (MAIA), using a custom grid of 33 points spanning the central 14 degrees of the macula. Each point was defined as abnormal if its threshold sensitivity was lower than 1.65 standard deviations (SD) (5%) or 2 SD (2.5%) than the expected threshold in healthy eyes according to the MAIA internal database. Among the 25 eyes there were 11.8 ± 9 and 8.4 ± 8.2 abnormal points at < 5% and < 2.5%, with mean deviation of thresholds from normal − 4.9 ± 1.2 dB and − 5.8 ± 1.5 dB, respectively. These deviations were greater, and their SD smaller, compared with the complete microperimetry grid, − 2.3 ± 2.0 dB. The 95% limits of agreement for average threshold between the 2 successive tests were smaller when only abnormal points were included. Analyzing only abnormal grid points yields an outcome parameter with a greater deviation from normal, a more homogenous dataset, and better test–retest variability, compared with analysis of all grid points. This parameter may thus be more sensitive to change, while moderately limiting the number of potential recruits. The proposed outcome measures should be further investigated as potential endpoints in clinical trials in iAMD.
format	article
author	Yaniv Barkana Susanne G. Pondorfer Steffen Schmitz-Valckenberg Hermann Russ Robert P. Finger
author_facet	Yaniv Barkana Susanne G. Pondorfer Steffen Schmitz-Valckenberg Hermann Russ Robert P. Finger
author_sort	Yaniv Barkana
title	Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration
title_short	Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration
title_full	Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration
title_fullStr	Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration
title_full_unstemmed	Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration
title_sort	improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/31ae2287517941dd8e27401ec84c95a9
work_keys_str_mv	AT yanivbarkana improvedsensitivityofmicroperimetricoutcomesforclinicalstudiesinagerelatedmaculardegeneration AT susannegpondorfer improvedsensitivityofmicroperimetricoutcomesforclinicalstudiesinagerelatedmaculardegeneration AT steffenschmitzvalckenberg improvedsensitivityofmicroperimetricoutcomesforclinicalstudiesinagerelatedmaculardegeneration AT hermannruss improvedsensitivityofmicroperimetricoutcomesforclinicalstudiesinagerelatedmaculardegeneration AT robertpfinger improvedsensitivityofmicroperimetricoutcomesforclinicalstudiesinagerelatedmaculardegeneration
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Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration

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