HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.

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Autores principales:	Ping-Chieh Pao, Debasis Patnaik, L. Ashley Watson, Fan Gao, Ling Pan, Jun Wang, Chinnakkaruppan Adaikkan, Jay Penney, Hugh P. Cam, Wen-Chin Huang, Lorena Pantano, Audrey Lee, Alexi Nott, Trongha X. Phan, Elizabeta Gjoneska, Sara Elmsaouri, Stephen J. Haggarty, Li-Huei Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31affdab15104a389accac5fde35981f
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spelling	oai:doaj.org-article:31affdab15104a389accac5fde35981f2021-12-02T14:58:44ZHDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease10.1038/s41467-020-16361-y2041-1723https://doaj.org/article/31affdab15104a389accac5fde35981f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16361-yhttps://doaj.org/toc/2041-1723Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.Ping-Chieh PaoDebasis PatnaikL. Ashley WatsonFan GaoLing PanJun WangChinnakkaruppan AdaikkanJay PenneyHugh P. CamWen-Chin HuangLorena PantanoAudrey LeeAlexi NottTrongha X. PhanElizabeta GjoneskaSara ElmsaouriStephen J. HaggartyLi-Huei TsaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ping-Chieh Pao Debasis Patnaik L. Ashley Watson Fan Gao Ling Pan Jun Wang Chinnakkaruppan Adaikkan Jay Penney Hugh P. Cam Wen-Chin Huang Lorena Pantano Audrey Lee Alexi Nott Trongha X. Phan Elizabeta Gjoneska Sara Elmsaouri Stephen J. Haggarty Li-Huei Tsai HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
description	Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.
format	article
author	Ping-Chieh Pao Debasis Patnaik L. Ashley Watson Fan Gao Ling Pan Jun Wang Chinnakkaruppan Adaikkan Jay Penney Hugh P. Cam Wen-Chin Huang Lorena Pantano Audrey Lee Alexi Nott Trongha X. Phan Elizabeta Gjoneska Sara Elmsaouri Stephen J. Haggarty Li-Huei Tsai
author_facet	Ping-Chieh Pao Debasis Patnaik L. Ashley Watson Fan Gao Ling Pan Jun Wang Chinnakkaruppan Adaikkan Jay Penney Hugh P. Cam Wen-Chin Huang Lorena Pantano Audrey Lee Alexi Nott Trongha X. Phan Elizabeta Gjoneska Sara Elmsaouri Stephen J. Haggarty Li-Huei Tsai
author_sort	Ping-Chieh Pao
title	HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
title_short	HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
title_full	HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
title_fullStr	HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
title_full_unstemmed	HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
title_sort	hdac1 modulates ogg1-initiated oxidative dna damage repair in the aging brain and alzheimer’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/31affdab15104a389accac5fde35981f
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HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

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