Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge
Evidence supports a role of complement anaphylatoxin C5a in the pathophysiology of COVID-19. However, information about the evolution and impact of C5a levels after hospital discharge is lacking. We analyzed the association between circulating C5a levels and the clinical evolution of hospitalized pa...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/31b08de42bbb44f58cc4a3cb1adaf7e5 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:31b08de42bbb44f58cc4a3cb1adaf7e5 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:31b08de42bbb44f58cc4a3cb1adaf7e52021-11-18T05:57:15ZPersistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge1664-322410.3389/fimmu.2021.767376https://doaj.org/article/31b08de42bbb44f58cc4a3cb1adaf7e52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.767376/fullhttps://doaj.org/toc/1664-3224Evidence supports a role of complement anaphylatoxin C5a in the pathophysiology of COVID-19. However, information about the evolution and impact of C5a levels after hospital discharge is lacking. We analyzed the association between circulating C5a levels and the clinical evolution of hospitalized patients infected with SARS-CoV-2. Serum C5a levels were determined in 32 hospitalized and 17 non-hospitalized patients from Clinica Universidad de Navarra. One hundred and eighty eight serial samples were collected during the hospitalization stay and up to three months during the follow-up. Median C5a levels were 27.71 ng/ml (25th to 75th percentile: 19.35-34.96) for samples collected during hospitalization, versus 16.76 ng/ml (12.90-25.08) for samples collected during the follow-up (p<0.001). There was a negative correlation between serum C5a levels and the number of days from symptom onset (p<0.001). C5a levels also correlated with a previously validated clinical risk score (p<0.001), and was associated with the severity of the disease (p<0.001). An overall reduction of C5a levels was observed after hospital discharge. However, elevated C5a levels persisted in those patients with high COVID-19 severity (i.e. those with a longest stay in the hospital), even after months from hospital discharge (p=0.020). Moreover, high C5a levels appeared to be associated with the presence of long-term respiratory symptoms (p=0.004). In conclusion, serum C5a levels remain high in severe cases of COVID-19, and are associated with the presence of respiratory symptoms after hospital discharge. These results may suggest a role for C5a in the long-term effects of COVID-19 infection.Yaiza SenentYaiza SenentYaiza SenentSusana InogésSusana InogésSusana InogésAscensión López-Díaz de CerioAscensión López-Díaz de CerioAscensión López-Díaz de CerioAndres BlancoArantxa CampoFrancisco Carmona-TorreFrancisco Carmona-TorreFrancisco Carmona-TorrePatricia SunsundeguiAntonio González-MartínAntonio González-MartínDaniel AjonaDaniel AjonaDaniel AjonaDaniel AjonaMarcin OkrójFelipe PrósperFelipe PrósperFelipe PrósperFelipe PrósperRuben PioRuben PioRuben PioRuben PioJosé Ramón YusteJosé Ramón YusteJosé Ramón YusteBeatriz TaviraBeatriz TaviraBeatriz TaviraFrontiers Media S.A.articleinnate immunitycomplement systemC5aCOVID-19SARS-CoV-2respiratory symptomsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
innate immunity complement system C5a COVID-19 SARS-CoV-2 respiratory symptoms Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
innate immunity complement system C5a COVID-19 SARS-CoV-2 respiratory symptoms Immunologic diseases. Allergy RC581-607 Yaiza Senent Yaiza Senent Yaiza Senent Susana Inogés Susana Inogés Susana Inogés Ascensión López-Díaz de Cerio Ascensión López-Díaz de Cerio Ascensión López-Díaz de Cerio Andres Blanco Arantxa Campo Francisco Carmona-Torre Francisco Carmona-Torre Francisco Carmona-Torre Patricia Sunsundegui Antonio González-Martín Antonio González-Martín Daniel Ajona Daniel Ajona Daniel Ajona Daniel Ajona Marcin Okrój Felipe Prósper Felipe Prósper Felipe Prósper Felipe Prósper Ruben Pio Ruben Pio Ruben Pio Ruben Pio José Ramón Yuste José Ramón Yuste José Ramón Yuste Beatriz Tavira Beatriz Tavira Beatriz Tavira Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge |
| description |
Evidence supports a role of complement anaphylatoxin C5a in the pathophysiology of COVID-19. However, information about the evolution and impact of C5a levels after hospital discharge is lacking. We analyzed the association between circulating C5a levels and the clinical evolution of hospitalized patients infected with SARS-CoV-2. Serum C5a levels were determined in 32 hospitalized and 17 non-hospitalized patients from Clinica Universidad de Navarra. One hundred and eighty eight serial samples were collected during the hospitalization stay and up to three months during the follow-up. Median C5a levels were 27.71 ng/ml (25th to 75th percentile: 19.35-34.96) for samples collected during hospitalization, versus 16.76 ng/ml (12.90-25.08) for samples collected during the follow-up (p<0.001). There was a negative correlation between serum C5a levels and the number of days from symptom onset (p<0.001). C5a levels also correlated with a previously validated clinical risk score (p<0.001), and was associated with the severity of the disease (p<0.001). An overall reduction of C5a levels was observed after hospital discharge. However, elevated C5a levels persisted in those patients with high COVID-19 severity (i.e. those with a longest stay in the hospital), even after months from hospital discharge (p=0.020). Moreover, high C5a levels appeared to be associated with the presence of long-term respiratory symptoms (p=0.004). In conclusion, serum C5a levels remain high in severe cases of COVID-19, and are associated with the presence of respiratory symptoms after hospital discharge. These results may suggest a role for C5a in the long-term effects of COVID-19 infection. |
| format |
article |
| author |
Yaiza Senent Yaiza Senent Yaiza Senent Susana Inogés Susana Inogés Susana Inogés Ascensión López-Díaz de Cerio Ascensión López-Díaz de Cerio Ascensión López-Díaz de Cerio Andres Blanco Arantxa Campo Francisco Carmona-Torre Francisco Carmona-Torre Francisco Carmona-Torre Patricia Sunsundegui Antonio González-Martín Antonio González-Martín Daniel Ajona Daniel Ajona Daniel Ajona Daniel Ajona Marcin Okrój Felipe Prósper Felipe Prósper Felipe Prósper Felipe Prósper Ruben Pio Ruben Pio Ruben Pio Ruben Pio José Ramón Yuste José Ramón Yuste José Ramón Yuste Beatriz Tavira Beatriz Tavira Beatriz Tavira |
| author_facet |
Yaiza Senent Yaiza Senent Yaiza Senent Susana Inogés Susana Inogés Susana Inogés Ascensión López-Díaz de Cerio Ascensión López-Díaz de Cerio Ascensión López-Díaz de Cerio Andres Blanco Arantxa Campo Francisco Carmona-Torre Francisco Carmona-Torre Francisco Carmona-Torre Patricia Sunsundegui Antonio González-Martín Antonio González-Martín Daniel Ajona Daniel Ajona Daniel Ajona Daniel Ajona Marcin Okrój Felipe Prósper Felipe Prósper Felipe Prósper Felipe Prósper Ruben Pio Ruben Pio Ruben Pio Ruben Pio José Ramón Yuste José Ramón Yuste José Ramón Yuste Beatriz Tavira Beatriz Tavira Beatriz Tavira |
| author_sort |
Yaiza Senent |
| title |
Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge |
| title_short |
Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge |
| title_full |
Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge |
| title_fullStr |
Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge |
| title_full_unstemmed |
Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge |
| title_sort |
persistence of high levels of serum complement c5a in severe covid-19 cases after hospital discharge |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/31b08de42bbb44f58cc4a3cb1adaf7e5 |
| work_keys_str_mv |
AT yaizasenent persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT yaizasenent persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT yaizasenent persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT susanainoges persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT susanainoges persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT susanainoges persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT ascensionlopezdiazdecerio persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT ascensionlopezdiazdecerio persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT ascensionlopezdiazdecerio persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT andresblanco persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT arantxacampo persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT franciscocarmonatorre persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT franciscocarmonatorre persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT franciscocarmonatorre persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT patriciasunsundegui persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT antoniogonzalezmartin persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT antoniogonzalezmartin persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT danielajona persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT danielajona persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT danielajona persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT danielajona persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT marcinokroj persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT felipeprosper persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT felipeprosper persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT felipeprosper persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT felipeprosper persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT rubenpio persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT rubenpio persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT rubenpio persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT rubenpio persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT joseramonyuste persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT joseramonyuste persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT joseramonyuste persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT beatriztavira persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT beatriztavira persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge AT beatriztavira persistenceofhighlevelsofserumcomplementc5ainseverecovid19casesafterhospitaldischarge |
| _version_ |
1718424656689496064 |