Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response to drugs, providing a suitable model for studie...

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Autores principales:	Masahide Kawatou, Hidetoshi Masumoto, Hiroyuki Fukushima, Gaku Morinaga, Ryuzo Sakata, Takashi Ashihara, Jun K. Yamashita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31b1d1a11b604437a3d12874b559b590
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spelling	oai:doaj.org-article:31b1d1a11b604437a3d12874b559b5902021-12-02T15:38:43ZModelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue10.1038/s41467-017-01125-y2041-1723https://doaj.org/article/31b1d1a11b604437a3d12874b559b5902017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01125-yhttps://doaj.org/toc/2041-1723Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response to drugs, providing a suitable model for studies of TdP mechanism and drug toxicity.Masahide KawatouHidetoshi MasumotoHiroyuki FukushimaGaku MorinagaRyuzo SakataTakashi AshiharaJun K. YamashitaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masahide Kawatou Hidetoshi Masumoto Hiroyuki Fukushima Gaku Morinaga Ryuzo Sakata Takashi Ashihara Jun K. Yamashita Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
description	Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response to drugs, providing a suitable model for studies of TdP mechanism and drug toxicity.
format	article
author	Masahide Kawatou Hidetoshi Masumoto Hiroyuki Fukushima Gaku Morinaga Ryuzo Sakata Takashi Ashihara Jun K. Yamashita
author_facet	Masahide Kawatou Hidetoshi Masumoto Hiroyuki Fukushima Gaku Morinaga Ryuzo Sakata Takashi Ashihara Jun K. Yamashita
author_sort	Masahide Kawatou
title	Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
title_short	Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
title_full	Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
title_fullStr	Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
title_full_unstemmed	Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
title_sort	modelling torsade de pointes arrhythmias in vitro in 3d human ips cell-engineered heart tissue
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/31b1d1a11b604437a3d12874b559b590
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Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

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