MicroRNA controlled adenovirus mediates anti-cancer efficacy without affecting endogenous microRNA activity.

MicroRNAs are small non-coding RNA molecules that regulate mRNA translation and stability by binding to complementary sequences usually within the 3' un-translated region (UTR). We have previously shown that the hepatic toxicity caused by wild-type Adenovirus 5 (Ad5WT) in mice can be prevented...

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Autores principales: Ryan Cawood, Suet-Ling Wong, Ying Di, Dilair F Baban, Leonard W Seymour
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/31b27a319ae14a5fb78d650d87af5e7b
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