Eltrombopag directly inhibits BAX and prevents cell death

The BCL-2 family protein BAX functions to regulate mitochondria-driven cell death. Here the authors show that the drug Eltrombopag inhibits BAX and prevents apoptosis induced by cytotoxic stimuli.

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Autores principales:	Adam Z. Spitz, Emmanouil Zacharioudakis, Denis E. Reyna, Thomas P. Garner, Evripidis Gavathiotis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31bab891d7f643189094349969145575
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spelling	oai:doaj.org-article:31bab891d7f6431890943499691455752021-12-02T14:03:40ZEltrombopag directly inhibits BAX and prevents cell death10.1038/s41467-021-21224-12041-1723https://doaj.org/article/31bab891d7f6431890943499691455752021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21224-1https://doaj.org/toc/2041-1723The BCL-2 family protein BAX functions to regulate mitochondria-driven cell death. Here the authors show that the drug Eltrombopag inhibits BAX and prevents apoptosis induced by cytotoxic stimuli.Adam Z. SpitzEmmanouil ZacharioudakisDenis E. ReynaThomas P. GarnerEvripidis GavathiotisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam Z. Spitz Emmanouil Zacharioudakis Denis E. Reyna Thomas P. Garner Evripidis Gavathiotis Eltrombopag directly inhibits BAX and prevents cell death
description	The BCL-2 family protein BAX functions to regulate mitochondria-driven cell death. Here the authors show that the drug Eltrombopag inhibits BAX and prevents apoptosis induced by cytotoxic stimuli.
format	article
author	Adam Z. Spitz Emmanouil Zacharioudakis Denis E. Reyna Thomas P. Garner Evripidis Gavathiotis
author_facet	Adam Z. Spitz Emmanouil Zacharioudakis Denis E. Reyna Thomas P. Garner Evripidis Gavathiotis
author_sort	Adam Z. Spitz
title	Eltrombopag directly inhibits BAX and prevents cell death
title_short	Eltrombopag directly inhibits BAX and prevents cell death
title_full	Eltrombopag directly inhibits BAX and prevents cell death
title_fullStr	Eltrombopag directly inhibits BAX and prevents cell death
title_full_unstemmed	Eltrombopag directly inhibits BAX and prevents cell death
title_sort	eltrombopag directly inhibits bax and prevents cell death
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/31bab891d7f643189094349969145575
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Eltrombopag directly inhibits BAX and prevents cell death

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