INTRACELLULAR SYSTEMS FOR DETECTION OF EXOGENOUS NUCLEIC ACIDS AND TRIGGERING MECHANISMS OF IMMUNE RESPONSE TO DNA INTERNALIZATION

Abstract. There are some specific mechanisms in cell that detect the invasion into the cell of any foreign molecules, so-called pathogen-associated molecular patterns (PAMPs). The recognition of these PAMPs is realized by Toll-like receptors or is due to the cytosolic sensors action. In recent years...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: E. A. Alyamkina, E. V. Dolgova, A. S. Proskurina, V. A. Rogachev, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev, M. A. Shurdov
Formato: article
Lenguaje:RU
Publicado: SPb RAACI 2014
Materias:
Acceso en línea:https://doaj.org/article/31bb2ddc9f8346cfb4498c44e6d6ed53
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:31bb2ddc9f8346cfb4498c44e6d6ed53
record_format dspace
spelling oai:doaj.org-article:31bb2ddc9f8346cfb4498c44e6d6ed532021-11-18T08:03:43ZINTRACELLULAR SYSTEMS FOR DETECTION OF EXOGENOUS NUCLEIC ACIDS AND TRIGGERING MECHANISMS OF IMMUNE RESPONSE TO DNA INTERNALIZATION1563-06252313-741X10.15789/1563-0625-2013-5-413-430https://doaj.org/article/31bb2ddc9f8346cfb4498c44e6d6ed532014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/658https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. There are some specific mechanisms in cell that detect the invasion into the cell of any foreign molecules, so-called pathogen-associated molecular patterns (PAMPs). The recognition of these PAMPs is realized by Toll-like receptors or is due to the cytosolic sensors action. In recent years much attention is directed to the investigation of foreign nucleic acids sensing and detection in cell. Nowadays some sensors of doublestranded DNA, such as STING, DAI, members of NOD-like protein family, RIG-like helicases, proteins of HIN-200 family are identified. Some of sensors interact with double-stranded DNA directly. The others are characterized as mediators of signal transduction from unknown DNA-sensor in the series of following molecular events. Induction of nuclear transcription factors NF-κB and IRF3/IRF7 to produce IFNβ or processing of proinflammatory cytokines IL-1β and IL-18 by means of inflammasome formation is a result of activation of cascade events induced by cytosolic DNA. In the review we combine information concerning signaling pathways characterized sensing of intracellular double-stranded DNA that results in the development of the cellular immune response.E. A. AlyamkinaE. V. DolgovaA. S. ProskurinaV. A. RogachevA. A. OstaninE. R. ChernykhS. S. BogachevM. A. ShurdovSPb RAACIarticlepathogen-associated molecular patterns (pamps)double-stranded dna (dsdna)cytosolic sensorinterferon-beta (ifnβ)inflammasomeImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 5, Pp 413-430 (2014)
institution DOAJ
collection DOAJ
language RU
topic pathogen-associated molecular patterns (pamps)
double-stranded dna (dsdna)
cytosolic sensor
interferon-beta (ifnβ)
inflammasome
Immunologic diseases. Allergy
RC581-607
spellingShingle pathogen-associated molecular patterns (pamps)
double-stranded dna (dsdna)
cytosolic sensor
interferon-beta (ifnβ)
inflammasome
Immunologic diseases. Allergy
RC581-607
E. A. Alyamkina
E. V. Dolgova
A. S. Proskurina
V. A. Rogachev
A. A. Ostanin
E. R. Chernykh
S. S. Bogachev
M. A. Shurdov
INTRACELLULAR SYSTEMS FOR DETECTION OF EXOGENOUS NUCLEIC ACIDS AND TRIGGERING MECHANISMS OF IMMUNE RESPONSE TO DNA INTERNALIZATION
description Abstract. There are some specific mechanisms in cell that detect the invasion into the cell of any foreign molecules, so-called pathogen-associated molecular patterns (PAMPs). The recognition of these PAMPs is realized by Toll-like receptors or is due to the cytosolic sensors action. In recent years much attention is directed to the investigation of foreign nucleic acids sensing and detection in cell. Nowadays some sensors of doublestranded DNA, such as STING, DAI, members of NOD-like protein family, RIG-like helicases, proteins of HIN-200 family are identified. Some of sensors interact with double-stranded DNA directly. The others are characterized as mediators of signal transduction from unknown DNA-sensor in the series of following molecular events. Induction of nuclear transcription factors NF-κB and IRF3/IRF7 to produce IFNβ or processing of proinflammatory cytokines IL-1β and IL-18 by means of inflammasome formation is a result of activation of cascade events induced by cytosolic DNA. In the review we combine information concerning signaling pathways characterized sensing of intracellular double-stranded DNA that results in the development of the cellular immune response.
format article
author E. A. Alyamkina
E. V. Dolgova
A. S. Proskurina
V. A. Rogachev
A. A. Ostanin
E. R. Chernykh
S. S. Bogachev
M. A. Shurdov
author_facet E. A. Alyamkina
E. V. Dolgova
A. S. Proskurina
V. A. Rogachev
A. A. Ostanin
E. R. Chernykh
S. S. Bogachev
M. A. Shurdov
author_sort E. A. Alyamkina
title INTRACELLULAR SYSTEMS FOR DETECTION OF EXOGENOUS NUCLEIC ACIDS AND TRIGGERING MECHANISMS OF IMMUNE RESPONSE TO DNA INTERNALIZATION
title_short INTRACELLULAR SYSTEMS FOR DETECTION OF EXOGENOUS NUCLEIC ACIDS AND TRIGGERING MECHANISMS OF IMMUNE RESPONSE TO DNA INTERNALIZATION
title_full INTRACELLULAR SYSTEMS FOR DETECTION OF EXOGENOUS NUCLEIC ACIDS AND TRIGGERING MECHANISMS OF IMMUNE RESPONSE TO DNA INTERNALIZATION
title_fullStr INTRACELLULAR SYSTEMS FOR DETECTION OF EXOGENOUS NUCLEIC ACIDS AND TRIGGERING MECHANISMS OF IMMUNE RESPONSE TO DNA INTERNALIZATION
title_full_unstemmed INTRACELLULAR SYSTEMS FOR DETECTION OF EXOGENOUS NUCLEIC ACIDS AND TRIGGERING MECHANISMS OF IMMUNE RESPONSE TO DNA INTERNALIZATION
title_sort intracellular systems for detection of exogenous nucleic acids and triggering mechanisms of immune response to dna internalization
publisher SPb RAACI
publishDate 2014
url https://doaj.org/article/31bb2ddc9f8346cfb4498c44e6d6ed53
work_keys_str_mv AT eaalyamkina intracellularsystemsfordetectionofexogenousnucleicacidsandtriggeringmechanismsofimmuneresponsetodnainternalization
AT evdolgova intracellularsystemsfordetectionofexogenousnucleicacidsandtriggeringmechanismsofimmuneresponsetodnainternalization
AT asproskurina intracellularsystemsfordetectionofexogenousnucleicacidsandtriggeringmechanismsofimmuneresponsetodnainternalization
AT varogachev intracellularsystemsfordetectionofexogenousnucleicacidsandtriggeringmechanismsofimmuneresponsetodnainternalization
AT aaostanin intracellularsystemsfordetectionofexogenousnucleicacidsandtriggeringmechanismsofimmuneresponsetodnainternalization
AT erchernykh intracellularsystemsfordetectionofexogenousnucleicacidsandtriggeringmechanismsofimmuneresponsetodnainternalization
AT ssbogachev intracellularsystemsfordetectionofexogenousnucleicacidsandtriggeringmechanismsofimmuneresponsetodnainternalization
AT mashurdov intracellularsystemsfordetectionofexogenousnucleicacidsandtriggeringmechanismsofimmuneresponsetodnainternalization
_version_ 1718422470460964864