Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches

Primary gastrointestinal (GI) T-cell neoplasms are extremely rare heterogeneous disease entities with distinct clinicopathologic features. Given the different prognoses of various disease subtypes, clinicians and pathologists must be aware of the key characteristics of these neoplasms, despite their...

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Autores principales:	Midori Filiz Nishimura, Yoshito Nishimura, Asami Nishikori, Tadashi Yoshino, Yasuharu Sato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	primary gastrointestinal T-cell lymphoma enteropathy-associated T-cell lymphoma EATL monomorphic epitheliotropic intestinal T-cell lymphoma MEITL indolent T-cell lymphoproliferative disorder Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/31bf6c2ba5f6423a849da0e6fb350261
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id	oai:doaj.org-article:31bf6c2ba5f6423a849da0e6fb350261
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spelling	oai:doaj.org-article:31bf6c2ba5f6423a849da0e6fb3502612021-11-25T17:03:49ZPrimary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches10.3390/cancers132257742072-6694https://doaj.org/article/31bf6c2ba5f6423a849da0e6fb3502612021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5774https://doaj.org/toc/2072-6694Primary gastrointestinal (GI) T-cell neoplasms are extremely rare heterogeneous disease entities with distinct clinicopathologic features. Given the different prognoses of various disease subtypes, clinicians and pathologists must be aware of the key characteristics of these neoplasms, despite their rarity. The two most common aggressive primary GI T-cell lymphomas are enteropathy-associated T-cell lymphoma and monomorphic epitheliotropic intestinal T-cell lymphoma. In addition, extranodal natural killer (NK)/T-cell lymphoma of the nasal type and anaplastic large cell lymphoma may also occur in the GI tract or involve it secondarily. In the revised 4th World Health Organization classification, indolent T-cell lymphoproliferative disorder of the GI tract has been incorporated as a provisional entity. In this review, we summarize up-to-date clinicopathological features of these disease entities, including the molecular characteristics of primary GI T-cell lymphomas and indolent lymphoproliferative disorders. We focus on the latest treatment approaches, which have not been summarized in existing reviews. Further, we provide a comprehensive review of available literature to address the following questions: How can pathologists discriminate subtypes with different clinical prognoses? How can primary GI neoplasms be distinguished from secondary involvement? How can these neoplasms be distinguished from non-specific inflammatory changes at an early stage?Midori Filiz NishimuraYoshito NishimuraAsami NishikoriTadashi YoshinoYasuharu SatoMDPI AGarticleprimary gastrointestinal T-cell lymphomaenteropathy-associated T-cell lymphomaEATLmonomorphic epitheliotropic intestinal T-cell lymphomaMEITLindolent T-cell lymphoproliferative disorderNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5774, p 5774 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	primary gastrointestinal T-cell lymphoma enteropathy-associated T-cell lymphoma EATL monomorphic epitheliotropic intestinal T-cell lymphoma MEITL indolent T-cell lymphoproliferative disorder Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	primary gastrointestinal T-cell lymphoma enteropathy-associated T-cell lymphoma EATL monomorphic epitheliotropic intestinal T-cell lymphoma MEITL indolent T-cell lymphoproliferative disorder Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Midori Filiz Nishimura Yoshito Nishimura Asami Nishikori Tadashi Yoshino Yasuharu Sato Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches
description	Primary gastrointestinal (GI) T-cell neoplasms are extremely rare heterogeneous disease entities with distinct clinicopathologic features. Given the different prognoses of various disease subtypes, clinicians and pathologists must be aware of the key characteristics of these neoplasms, despite their rarity. The two most common aggressive primary GI T-cell lymphomas are enteropathy-associated T-cell lymphoma and monomorphic epitheliotropic intestinal T-cell lymphoma. In addition, extranodal natural killer (NK)/T-cell lymphoma of the nasal type and anaplastic large cell lymphoma may also occur in the GI tract or involve it secondarily. In the revised 4th World Health Organization classification, indolent T-cell lymphoproliferative disorder of the GI tract has been incorporated as a provisional entity. In this review, we summarize up-to-date clinicopathological features of these disease entities, including the molecular characteristics of primary GI T-cell lymphomas and indolent lymphoproliferative disorders. We focus on the latest treatment approaches, which have not been summarized in existing reviews. Further, we provide a comprehensive review of available literature to address the following questions: How can pathologists discriminate subtypes with different clinical prognoses? How can primary GI neoplasms be distinguished from secondary involvement? How can these neoplasms be distinguished from non-specific inflammatory changes at an early stage?
format	article
author	Midori Filiz Nishimura Yoshito Nishimura Asami Nishikori Tadashi Yoshino Yasuharu Sato
author_facet	Midori Filiz Nishimura Yoshito Nishimura Asami Nishikori Tadashi Yoshino Yasuharu Sato
author_sort	Midori Filiz Nishimura
title	Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches
title_short	Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches
title_full	Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches
title_fullStr	Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches
title_full_unstemmed	Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches
title_sort	primary gastrointestinal t-cell lymphoma and indolent lymphoproliferative disorders: practical diagnostic and treatment approaches
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/31bf6c2ba5f6423a849da0e6fb350261
work_keys_str_mv	AT midorifiliznishimura primarygastrointestinaltcelllymphomaandindolentlymphoproliferativedisorderspracticaldiagnosticandtreatmentapproaches AT yoshitonishimura primarygastrointestinaltcelllymphomaandindolentlymphoproliferativedisorderspracticaldiagnosticandtreatmentapproaches AT asaminishikori primarygastrointestinaltcelllymphomaandindolentlymphoproliferativedisorderspracticaldiagnosticandtreatmentapproaches AT tadashiyoshino primarygastrointestinaltcelllymphomaandindolentlymphoproliferativedisorderspracticaldiagnosticandtreatmentapproaches AT yasuharusato primarygastrointestinaltcelllymphomaandindolentlymphoproliferativedisorderspracticaldiagnosticandtreatmentapproaches
_version_	1718412767179833344

Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches

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