Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Laine de Carvalho Guerra Pessoa Mamede,1 Rafaela Lira Formiga Cavalcanti de Lima,2 Alexandre Sérgio Silva,1 João Carlos Lima Rodrigues Pita,3 Nadjeanny Ingrid Galdino Gomes,1 Elisama Araújo de Sena,1 Rhayra Priscila Moraes Nobrega,2 João Otávio...
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Dove Medical Press
2021
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oai:doaj.org-article:31bfb78cadff4604a11b4bcbfff3d9fa2021-12-02T14:16:31ZEffects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial1178-7007https://doaj.org/article/31bfb78cadff4604a11b4bcbfff3d9fa2021-02-01T00:00:00Zhttps://www.dovepress.com/effects-of-a-single-oral-megadose-of-vitamin-d3-on-inflammation-and-ox-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Laine de Carvalho Guerra Pessoa Mamede,1 Rafaela Lira Formiga Cavalcanti de Lima,2 Alexandre Sérgio Silva,1 João Carlos Lima Rodrigues Pita,3 Nadjeanny Ingrid Galdino Gomes,1 Elisama Araújo de Sena,1 Rhayra Priscila Moraes Nobrega,2 João Otávio Scarano Alcântara,2 Julie Hanna Fontes de Souza,2 Glêbia Alexa Cardoso,3 José Luiz de Brito Alves,1 Maria da Conceição Rodrigues Gonçalves1 1Post-Graduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil; 2Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil; 3Health Sciences Center, Federal University of Paraíba, João Pessoa, BrazilCorrespondence: Laine de Carvalho Guerra Pessoa MamedeDepartment of Nutrition, Health Sciences Center, Universidade Federal da Paraíba, Campus I – Jd, Cidade Universitária, João Pessoa, PB, CEP: 58051-900, BrazilTel/Fax +55 83 9 91089818Email laineguerramamede@gmail.comAim: The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D.Methods: Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 intervention. Patients in the supplemented group received a single oral megadose of VD3 (VD3, n=14). Patients in placebo group received a single oral identical capsule without vitamin D (placebo, n = 15). Anthropometric and biochemical variables were assessed at baseline and after 4-weeks intervention.Results: Anthropometric variables (waist circumference, waist–hip ratio, waist–height ratio and body mass index) were similar between groups (p > 0.05). VD3 supplementation increased the serum levels of 25-hydroxyvitamin D (p=0.000), malondialdehyde (p=0.021) and C-reactive protein (p=0.043) in overweight and obese women. Additionally, VD3 supplementation reduced the serum levels of aspartate aminotransferase (AST, p=0.035), alanine aminotransferase (ALT, p< 0.0001) in overweight and obese women. Despite this, the serum levels of parathyroid hormone (PTH), fasting glucose (FG), and alpha-1- acid glycoprotein (A1GPA), total antioxidant capacity (TAC) were similar between groups.Conclusion: In summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers.Keywords: vitamin D, obesity, inflammation, lipid peroxidationPessoa Mamede LCGde Lima RLFCSilva ASRodrigues Pita JCLGaldino Gomes NIde Sena EAMoraes Nobrega RPScarano Alcântara JOFontes de Souza JHCardoso GAde Brito Alves JLRodrigues Gonçalves MCDove Medical Pressarticlevitamin d. obesity. inflammation. lipid peroxidation.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 525-534 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
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vitamin d. obesity. inflammation. lipid peroxidation. Specialties of internal medicine RC581-951 |
| spellingShingle |
vitamin d. obesity. inflammation. lipid peroxidation. Specialties of internal medicine RC581-951 Pessoa Mamede LCG de Lima RLFC Silva AS Rodrigues Pita JCL Galdino Gomes NI de Sena EA Moraes Nobrega RP Scarano Alcântara JO Fontes de Souza JH Cardoso GA de Brito Alves JL Rodrigues Gonçalves MC Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| description |
Laine de Carvalho Guerra Pessoa Mamede,1 Rafaela Lira Formiga Cavalcanti de Lima,2 Alexandre Sérgio Silva,1 João Carlos Lima Rodrigues Pita,3 Nadjeanny Ingrid Galdino Gomes,1 Elisama Araújo de Sena,1 Rhayra Priscila Moraes Nobrega,2 João Otávio Scarano Alcântara,2 Julie Hanna Fontes de Souza,2 Glêbia Alexa Cardoso,3 José Luiz de Brito Alves,1 Maria da Conceição Rodrigues Gonçalves1 1Post-Graduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil; 2Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil; 3Health Sciences Center, Federal University of Paraíba, João Pessoa, BrazilCorrespondence: Laine de Carvalho Guerra Pessoa MamedeDepartment of Nutrition, Health Sciences Center, Universidade Federal da Paraíba, Campus I – Jd, Cidade Universitária, João Pessoa, PB, CEP: 58051-900, BrazilTel/Fax +55 83 9 91089818Email laineguerramamede@gmail.comAim: The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D.Methods: Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 intervention. Patients in the supplemented group received a single oral megadose of VD3 (VD3, n=14). Patients in placebo group received a single oral identical capsule without vitamin D (placebo, n = 15). Anthropometric and biochemical variables were assessed at baseline and after 4-weeks intervention.Results: Anthropometric variables (waist circumference, waist–hip ratio, waist–height ratio and body mass index) were similar between groups (p > 0.05). VD3 supplementation increased the serum levels of 25-hydroxyvitamin D (p=0.000), malondialdehyde (p=0.021) and C-reactive protein (p=0.043) in overweight and obese women. Additionally, VD3 supplementation reduced the serum levels of aspartate aminotransferase (AST, p=0.035), alanine aminotransferase (ALT, p< 0.0001) in overweight and obese women. Despite this, the serum levels of parathyroid hormone (PTH), fasting glucose (FG), and alpha-1- acid glycoprotein (A1GPA), total antioxidant capacity (TAC) were similar between groups.Conclusion: In summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers.Keywords: vitamin D, obesity, inflammation, lipid peroxidation |
| format |
article |
| author |
Pessoa Mamede LCG de Lima RLFC Silva AS Rodrigues Pita JCL Galdino Gomes NI de Sena EA Moraes Nobrega RP Scarano Alcântara JO Fontes de Souza JH Cardoso GA de Brito Alves JL Rodrigues Gonçalves MC |
| author_facet |
Pessoa Mamede LCG de Lima RLFC Silva AS Rodrigues Pita JCL Galdino Gomes NI de Sena EA Moraes Nobrega RP Scarano Alcântara JO Fontes de Souza JH Cardoso GA de Brito Alves JL Rodrigues Gonçalves MC |
| author_sort |
Pessoa Mamede LCG |
| title |
Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_short |
Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_full |
Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_fullStr |
Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_full_unstemmed |
Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_sort |
effects of a single oral megadose of vitamin d3 on inflammation and oxidative stress markers in overweight and obese women: a randomized, double-blind, placebo-controlled clinical trial |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/31bfb78cadff4604a11b4bcbfff3d9fa |
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