Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates

Abstract Lipidome-wide metabolites may be useful biomarkers of pregnancy outcomes. We sought to characterize maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters. Plasma samples were collected 24–28 weeks gestation, and lipidomic profiling was quantified...

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Autores principales:	Max T. Aung, Pahriya Ashrap, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario, Carmen M. Vélez-Vega, Akram N. Alshawabkeh, José F. Cordero, John D. Meeker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31c3b85f803e45449037c4d9ccca62a5
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spelling	oai:doaj.org-article:31c3b85f803e45449037c4d9ccca62a52021-12-02T18:03:07ZMaternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates10.1038/s41598-021-87472-92045-2322https://doaj.org/article/31c3b85f803e45449037c4d9ccca62a52021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87472-9https://doaj.org/toc/2045-2322Abstract Lipidome-wide metabolites may be useful biomarkers of pregnancy outcomes. We sought to characterize maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters. Plasma samples were collected 24–28 weeks gestation, and lipidomic profiling was quantified using high-performance liquid chromatography tandem mass spectrometry. Lipid metabolites were analyzed individually and as whole lipid classes and subgroups based on degree of hydrocarbon chain saturation. Associations were estimated using linear and logistic regression. After false discovery adjustment (q < 0.15), four plasmenyl-phosphatidylethanolamines and three free fatty acids associated with increased risk for spontaneous preterm birth. Five phosphatidylinositols, two phosphatidylglycerols, and one phosphatidic acid were associated with large for gestational age neonates. The saturated plasmenyl-phosphatidylethanolamines held the association with increased risk for spontaneous preterm birth. Both the mono- and poly-unsaturated free fatty acids held the association for increased risk for spontaneous preterm birth. Mono- and poly-unsaturated phosphatidylinositols were associated with large for gestational age neonates. Whole lipid classes (plasmenyl-phophatidylcholines and plasmenyl-phosphatidylethanolamines) were associated with increased risk for large for gestational age at delivery. This study provides evidence that finer omics-scale analysis of the maternal lipidome may be more informative biomarkers of pregnancy outcomes compared to whole class level lipid analysis.Max T. AungPahriya AshrapDeborah J. WatkinsBhramar MukherjeeZaira RosarioCarmen M. Vélez-VegaAkram N. AlshawabkehJosé F. CorderoJohn D. MeekerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Max T. Aung Pahriya Ashrap Deborah J. Watkins Bhramar Mukherjee Zaira Rosario Carmen M. Vélez-Vega Akram N. Alshawabkeh José F. Cordero John D. Meeker Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
description	Abstract Lipidome-wide metabolites may be useful biomarkers of pregnancy outcomes. We sought to characterize maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters. Plasma samples were collected 24–28 weeks gestation, and lipidomic profiling was quantified using high-performance liquid chromatography tandem mass spectrometry. Lipid metabolites were analyzed individually and as whole lipid classes and subgroups based on degree of hydrocarbon chain saturation. Associations were estimated using linear and logistic regression. After false discovery adjustment (q < 0.15), four plasmenyl-phosphatidylethanolamines and three free fatty acids associated with increased risk for spontaneous preterm birth. Five phosphatidylinositols, two phosphatidylglycerols, and one phosphatidic acid were associated with large for gestational age neonates. The saturated plasmenyl-phosphatidylethanolamines held the association with increased risk for spontaneous preterm birth. Both the mono- and poly-unsaturated free fatty acids held the association for increased risk for spontaneous preterm birth. Mono- and poly-unsaturated phosphatidylinositols were associated with large for gestational age neonates. Whole lipid classes (plasmenyl-phophatidylcholines and plasmenyl-phosphatidylethanolamines) were associated with increased risk for large for gestational age at delivery. This study provides evidence that finer omics-scale analysis of the maternal lipidome may be more informative biomarkers of pregnancy outcomes compared to whole class level lipid analysis.
format	article
author	Max T. Aung Pahriya Ashrap Deborah J. Watkins Bhramar Mukherjee Zaira Rosario Carmen M. Vélez-Vega Akram N. Alshawabkeh José F. Cordero John D. Meeker
author_facet	Max T. Aung Pahriya Ashrap Deborah J. Watkins Bhramar Mukherjee Zaira Rosario Carmen M. Vélez-Vega Akram N. Alshawabkeh José F. Cordero John D. Meeker
author_sort	Max T. Aung
title	Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
title_short	Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
title_full	Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
title_fullStr	Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
title_full_unstemmed	Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
title_sort	maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/31c3b85f803e45449037c4d9ccca62a5
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Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates

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