The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant

Avian influenza A virus (IAV) strains replicate poorly in mammalian hosts, but mechanisms underlying species restriction are incompletely understood. Here, Bogdanow et al. show that avian and mammalian adapted IAV strains have evolved different RNA structure features for regulation of M segment RNA...

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Detalles Bibliográficos
Autores principales: Boris Bogdanow, Xi Wang, Katrin Eichelbaum, Anne Sadewasser, Immanuel Husic, Katharina Paki, Matthias Budt, Martha Hergeselle, Barbara Vetter, Jingyi Hou, Wei Chen, Lüder Wiebusch, Irmtraud M. Meyer, Thorsten Wolff, Matthias Selbach
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/31c5226fb8bf4e6b9bc945e1829498fd
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Sumario:Avian influenza A virus (IAV) strains replicate poorly in mammalian hosts, but mechanisms underlying species restriction are incompletely understood. Here, Bogdanow et al. show that avian and mammalian adapted IAV strains have evolved different RNA structure features for regulation of M segment RNA splicing.

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