The cytochrome P450 (CYP) superfamily in cnidarians

Abstract The cytochrome P450 (CYP) superfamily is a diverse and important enzyme family, playing a central role in chemical defense and in synthesis and metabolism of major biological signaling molecules. The CYPomes of four cnidarian genomes (Hydra vulgaris, Acropora digitifera, Aurelia aurita, Nem...

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Autores principales:	Kirill V. Pankov, Andrew G. McArthur, David A. Gold, David R. Nelson, Jared V. Goldstone, Joanna Y. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31c742e7a9464bb5a539b3d11377002a
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spelling	oai:doaj.org-article:31c742e7a9464bb5a539b3d11377002a2021-12-02T15:36:13ZThe cytochrome P450 (CYP) superfamily in cnidarians10.1038/s41598-021-88700-y2045-2322https://doaj.org/article/31c742e7a9464bb5a539b3d11377002a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88700-yhttps://doaj.org/toc/2045-2322Abstract The cytochrome P450 (CYP) superfamily is a diverse and important enzyme family, playing a central role in chemical defense and in synthesis and metabolism of major biological signaling molecules. The CYPomes of four cnidarian genomes (Hydra vulgaris, Acropora digitifera, Aurelia aurita, Nematostella vectensis) were annotated; phylogenetic analyses determined the evolutionary relationships amongst the sequences and with existing metazoan CYPs. 155 functional CYPs were identified and 90 fragments. Genes were from 24 new CYP families and several new subfamilies; genes were in 9 of the 12 established metazoan CYP clans. All species had large expansions of clan 2 diversity, with H. vulgaris having reduced diversity for both clan 3 and mitochondrial clan. We identified potential candidates for xenobiotic metabolism and steroidogenesis. That each genome contained multiple, novel CYP families may reflect the large evolutionary distance within the cnidarians, unique physiology in the cnidarian classes, and/or different ecology of the individual species.Kirill V. PankovAndrew G. McArthurDavid A. GoldDavid R. NelsonJared V. GoldstoneJoanna Y. WilsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kirill V. Pankov Andrew G. McArthur David A. Gold David R. Nelson Jared V. Goldstone Joanna Y. Wilson The cytochrome P450 (CYP) superfamily in cnidarians
description	Abstract The cytochrome P450 (CYP) superfamily is a diverse and important enzyme family, playing a central role in chemical defense and in synthesis and metabolism of major biological signaling molecules. The CYPomes of four cnidarian genomes (Hydra vulgaris, Acropora digitifera, Aurelia aurita, Nematostella vectensis) were annotated; phylogenetic analyses determined the evolutionary relationships amongst the sequences and with existing metazoan CYPs. 155 functional CYPs were identified and 90 fragments. Genes were from 24 new CYP families and several new subfamilies; genes were in 9 of the 12 established metazoan CYP clans. All species had large expansions of clan 2 diversity, with H. vulgaris having reduced diversity for both clan 3 and mitochondrial clan. We identified potential candidates for xenobiotic metabolism and steroidogenesis. That each genome contained multiple, novel CYP families may reflect the large evolutionary distance within the cnidarians, unique physiology in the cnidarian classes, and/or different ecology of the individual species.
format	article
author	Kirill V. Pankov Andrew G. McArthur David A. Gold David R. Nelson Jared V. Goldstone Joanna Y. Wilson
author_facet	Kirill V. Pankov Andrew G. McArthur David A. Gold David R. Nelson Jared V. Goldstone Joanna Y. Wilson
author_sort	Kirill V. Pankov
title	The cytochrome P450 (CYP) superfamily in cnidarians
title_short	The cytochrome P450 (CYP) superfamily in cnidarians
title_full	The cytochrome P450 (CYP) superfamily in cnidarians
title_fullStr	The cytochrome P450 (CYP) superfamily in cnidarians
title_full_unstemmed	The cytochrome P450 (CYP) superfamily in cnidarians
title_sort	cytochrome p450 (cyp) superfamily in cnidarians
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/31c742e7a9464bb5a539b3d11377002a
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The cytochrome P450 (CYP) superfamily in cnidarians

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