Analysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment.

<h4>Background</h4>To investigate the daily insulin doses and the ratio of basal insulin to total daily insulin in Chinese type 2 diabetic patients who received basal bolus insulin therapy.<h4>Methodology/principal findings</h4>Totally 2480 patients prescribed with pre-meal b...

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Autores principales:	Xiaoling Cai, Xueyao Han, Yingying Luo, Linong Ji
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31cad32817304075b65a8efa82680f9f
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spelling	oai:doaj.org-article:31cad32817304075b65a8efa82680f9f2021-11-18T07:15:16ZAnalysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment.1932-620310.1371/journal.pone.0038962https://doaj.org/article/31cad32817304075b65a8efa82680f9f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22720003/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To investigate the daily insulin doses and the ratio of basal insulin to total daily insulin in Chinese type 2 diabetic patients who received basal bolus insulin therapy.<h4>Methodology/principal findings</h4>Totally 2480 patients prescribed with pre-meal bolus insulin and bedtime basal insulin were included. The mean daily insulin doses was 38.22 ± 14.92 IU/day, the mean daily insulin doses per weight was 0.58 ± 0.22 IU/kg, the mean bolus insulin dose was 0.44 ± 0.17 IU/kg and the mean basal insulin dose was 0.13 ± 0.08 IU/kg. The mean basal/total daily insulin ratio (BD/TDD) was 0.23 ± 0.08. In most patients (47.94%), the BD/TDD was between 0.20 and 0.30. Diabetic duration, BMI, HbA1c, fasting and postprandial blood glucose level were positively associated with daily insulin dose, while age was negatively associated with daily insulin dose. Diabetic duration, BMI, HbA1c, fasting blood glucose level, and using metformin were positively associated with BD/TDD ratio, while age, postprandial C peptide, postprandial blood glucose level and CRE level were negatively associated with BD/TDD ratio.<h4>Conclusions/significance</h4>The daily insulin doses of intensive treatment in Chinese type 2 diabetic patients was 38.22 IU/day, the mean daily insulin doses per weight was 0.58 IU/kg, mean BD/TDD ratio was 0.23.Xiaoling CaiXueyao HanYingying LuoLinong JiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e38962 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoling Cai Xueyao Han Yingying Luo Linong Ji Analysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment.
description	<h4>Background</h4>To investigate the daily insulin doses and the ratio of basal insulin to total daily insulin in Chinese type 2 diabetic patients who received basal bolus insulin therapy.<h4>Methodology/principal findings</h4>Totally 2480 patients prescribed with pre-meal bolus insulin and bedtime basal insulin were included. The mean daily insulin doses was 38.22 ± 14.92 IU/day, the mean daily insulin doses per weight was 0.58 ± 0.22 IU/kg, the mean bolus insulin dose was 0.44 ± 0.17 IU/kg and the mean basal insulin dose was 0.13 ± 0.08 IU/kg. The mean basal/total daily insulin ratio (BD/TDD) was 0.23 ± 0.08. In most patients (47.94%), the BD/TDD was between 0.20 and 0.30. Diabetic duration, BMI, HbA1c, fasting and postprandial blood glucose level were positively associated with daily insulin dose, while age was negatively associated with daily insulin dose. Diabetic duration, BMI, HbA1c, fasting blood glucose level, and using metformin were positively associated with BD/TDD ratio, while age, postprandial C peptide, postprandial blood glucose level and CRE level were negatively associated with BD/TDD ratio.<h4>Conclusions/significance</h4>The daily insulin doses of intensive treatment in Chinese type 2 diabetic patients was 38.22 IU/day, the mean daily insulin doses per weight was 0.58 IU/kg, mean BD/TDD ratio was 0.23.
format	article
author	Xiaoling Cai Xueyao Han Yingying Luo Linong Ji
author_facet	Xiaoling Cai Xueyao Han Yingying Luo Linong Ji
author_sort	Xiaoling Cai
title	Analysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment.
title_short	Analysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment.
title_full	Analysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment.
title_fullStr	Analysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment.
title_full_unstemmed	Analysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment.
title_sort	analysis of insulin doses of chinese type 2 diabetic patients with intensive insulin treatment.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/31cad32817304075b65a8efa82680f9f
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Analysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment.

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