Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence

Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence

Catalytic asymmetric dearomatization (CADA) reactions readily convert common aromatic compounds to diverse 3D chiral, polycyclic molecules. Here, the authors report an intermolecular asymmetric dearomatization of nucleophile-tethered α-naphthols affording functionalized cyclic ketones with high enan...

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Main Authors: Zi-Lei Xia, Chao Zheng, Ren-Qi Xu, Shu-Li You
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/31cc1e810a644c278f364383ca0dac1c
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spelling oai:doaj.org-article:31cc1e810a644c278f364383ca0dac1c2021-12-02T14:38:38ZChiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence10.1038/s41467-019-11109-92041-1723https://doaj.org/article/31cc1e810a644c278f364383ca0dac1c2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11109-9https://doaj.org/toc/2041-1723Catalytic asymmetric dearomatization (CADA) reactions readily convert common aromatic compounds to diverse 3D chiral, polycyclic molecules. Here, the authors report an intermolecular asymmetric dearomatization of nucleophile-tethered α-naphthols affording functionalized cyclic ketones with high enantioselectivity.Zi-Lei XiaChao ZhengRen-Qi XuShu-Li YouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zi-Lei Xia
Chao Zheng
Ren-Qi Xu
Shu-Li You
Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence
description Catalytic asymmetric dearomatization (CADA) reactions readily convert common aromatic compounds to diverse 3D chiral, polycyclic molecules. Here, the authors report an intermolecular asymmetric dearomatization of nucleophile-tethered α-naphthols affording functionalized cyclic ketones with high enantioselectivity.
format article
author Zi-Lei Xia
Chao Zheng
Ren-Qi Xu
Shu-Li You
author_facet Zi-Lei Xia
Chao Zheng
Ren-Qi Xu
Shu-Li You
author_sort Zi-Lei Xia
title Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence
title_short Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence
title_full Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence
title_fullStr Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence
title_full_unstemmed Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence
title_sort chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/michael addition sequence
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/31cc1e810a644c278f364383ca0dac1c
work_keys_str_mv AT zileixia chiralphosphoricacidcatalyzedaminativedearomatizationofanaphtholsmichaeladditionsequence
AT chaozheng chiralphosphoricacidcatalyzedaminativedearomatizationofanaphtholsmichaeladditionsequence
AT renqixu chiralphosphoricacidcatalyzedaminativedearomatizationofanaphtholsmichaeladditionsequence
AT shuliyou chiralphosphoricacidcatalyzedaminativedearomatizationofanaphtholsmichaeladditionsequence
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