Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence
Catalytic asymmetric dearomatization (CADA) reactions readily convert common aromatic compounds to diverse 3D chiral, polycyclic molecules. Here, the authors report an intermolecular asymmetric dearomatization of nucleophile-tethered α-naphthols affording functionalized cyclic ketones with high enan...
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2019
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oai:doaj.org-article:31cc1e810a644c278f364383ca0dac1c2021-12-02T14:38:38ZChiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence10.1038/s41467-019-11109-92041-1723https://doaj.org/article/31cc1e810a644c278f364383ca0dac1c2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11109-9https://doaj.org/toc/2041-1723Catalytic asymmetric dearomatization (CADA) reactions readily convert common aromatic compounds to diverse 3D chiral, polycyclic molecules. Here, the authors report an intermolecular asymmetric dearomatization of nucleophile-tethered α-naphthols affording functionalized cyclic ketones with high enantioselectivity.Zi-Lei XiaChao ZhengRen-Qi XuShu-Li YouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019) |
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Science Q Zi-Lei Xia Chao Zheng Ren-Qi Xu Shu-Li You Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence |
description |
Catalytic asymmetric dearomatization (CADA) reactions readily convert common aromatic compounds to diverse 3D chiral, polycyclic molecules. Here, the authors report an intermolecular asymmetric dearomatization of nucleophile-tethered α-naphthols affording functionalized cyclic ketones with high enantioselectivity. |
format |
article |
author |
Zi-Lei Xia Chao Zheng Ren-Qi Xu Shu-Li You |
author_facet |
Zi-Lei Xia Chao Zheng Ren-Qi Xu Shu-Li You |
author_sort |
Zi-Lei Xia |
title |
Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence |
title_short |
Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence |
title_full |
Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence |
title_fullStr |
Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence |
title_full_unstemmed |
Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence |
title_sort |
chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/michael addition sequence |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/31cc1e810a644c278f364383ca0dac1c |
work_keys_str_mv |
AT zileixia chiralphosphoricacidcatalyzedaminativedearomatizationofanaphtholsmichaeladditionsequence AT chaozheng chiralphosphoricacidcatalyzedaminativedearomatizationofanaphtholsmichaeladditionsequence AT renqixu chiralphosphoricacidcatalyzedaminativedearomatizationofanaphtholsmichaeladditionsequence AT shuliyou chiralphosphoricacidcatalyzedaminativedearomatizationofanaphtholsmichaeladditionsequence |
_version_ |
1718390883955507200 |