Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism

Ericsson et al. show that different vendors (suppliers of mouse strains) harbor distinct microbiomes, which drive distinct behavioral phenotypes when the genetics are fixed. They specifically focus on changes relating to exploratory and anxiety-related behavior, physiological phenotypic parameters,...

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Autores principales:	Aaron C. Ericsson, Marcia L. Hart, Jessica Kwan, Louise Lanoue, Lynette R. Bower, Renee Araiza, K. C. Kent Lloyd, Craig L. Franklin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/31cee5810a5f4047a8f974fafbfdccee
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spelling	oai:doaj.org-article:31cee5810a5f4047a8f974fafbfdccee2021-12-02T15:02:51ZSupplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism10.1038/s42003-021-02249-02399-3642https://doaj.org/article/31cee5810a5f4047a8f974fafbfdccee2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02249-0https://doaj.org/toc/2399-3642Ericsson et al. show that different vendors (suppliers of mouse strains) harbor distinct microbiomes, which drive distinct behavioral phenotypes when the genetics are fixed. They specifically focus on changes relating to exploratory and anxiety-related behavior, physiological phenotypic parameters, glucose metabolism, and blood leukocytes. They conclude by emphasizing that supplier-origin fecal microbiomes represent potential sources of poor experimental reproducibility and suggest means to optimize experimentation with mice and their microbiomes.Aaron C. EricssonMarcia L. HartJessica KwanLouise LanoueLynette R. BowerRenee AraizaK. C. Kent LloydCraig L. FranklinNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Aaron C. Ericsson Marcia L. Hart Jessica Kwan Louise Lanoue Lynette R. Bower Renee Araiza K. C. Kent Lloyd Craig L. Franklin Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
description	Ericsson et al. show that different vendors (suppliers of mouse strains) harbor distinct microbiomes, which drive distinct behavioral phenotypes when the genetics are fixed. They specifically focus on changes relating to exploratory and anxiety-related behavior, physiological phenotypic parameters, glucose metabolism, and blood leukocytes. They conclude by emphasizing that supplier-origin fecal microbiomes represent potential sources of poor experimental reproducibility and suggest means to optimize experimentation with mice and their microbiomes.
format	article
author	Aaron C. Ericsson Marcia L. Hart Jessica Kwan Louise Lanoue Lynette R. Bower Renee Araiza K. C. Kent Lloyd Craig L. Franklin
author_facet	Aaron C. Ericsson Marcia L. Hart Jessica Kwan Louise Lanoue Lynette R. Bower Renee Araiza K. C. Kent Lloyd Craig L. Franklin
author_sort	Aaron C. Ericsson
title	Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_short	Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_full	Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_fullStr	Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_full_unstemmed	Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_sort	supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/31cee5810a5f4047a8f974fafbfdccee
work_keys_str_mv	AT aaroncericsson supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism AT marcialhart supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism AT jessicakwan supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism AT louiselanoue supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism AT lynetterbower supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism AT reneearaiza supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism AT kckentlloyd supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism AT craiglfranklin supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism
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Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism

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