Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping

Narong Khuntikeo, 1 Attapol Titapun, 1 Nittaya Chamadol, 2 Wuttisak Boonphongsathien, 2 Prakasit Sa-Ngiamwibool, 3 Simon D Taylor-Robinson, 4 Christopher A Wadsworth, 4 Shuo Zhang, 5 Evdokia M Kardoulaki, 6 Ian R Young 6,&dagger;, Richard RA Syms 6 1Department of Surgery, Faculty of Medicine, K...

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Autores principales:	Khuntikeo N, Titapun A, Chamadol N, Boonphongsathien W, Sa-Ngiamwibool P, Taylor-Robinson SD, Wadsworth CA, Zhang S, Kardoulaki EM, Young IR, Syms RRA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cholangiocarcinoma t2 mapping internal coil Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/31d143efa27f4cb4b7486ead4112c669
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spelling	oai:doaj.org-article:31d143efa27f4cb4b7486ead4112c6692021-12-02T09:24:01ZImproving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping1179-1535https://doaj.org/article/31d143efa27f4cb4b7486ead4112c6692020-03-01T00:00:00Zhttps://www.dovepress.com/improving-the-detection-of-cholangiocarcinoma-in-vitro-mri-based-study-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Narong Khuntikeo, 1 Attapol Titapun, 1 Nittaya Chamadol, 2 Wuttisak Boonphongsathien, 2 Prakasit Sa-Ngiamwibool, 3 Simon D Taylor-Robinson, 4 Christopher A Wadsworth, 4 Shuo Zhang, 5 Evdokia M Kardoulaki, 6 Ian R Young 6,&dagger;, Richard RA Syms 6 1Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 2Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 3Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 4Division of Surgery and Cancer, Imperial College London, Liver Unit, St. Mary’s Hospital, London W2 1NY, UK; 5Philips Healthcare Germany, Health Systems, Clinical Science, Hamburg 22335, Germany; 6EEE Department, Imperial College, London SW7 2AZ, UK&dagger;Ian R Young passed away on September 27, 2019Correspondence: Simon D Taylor-RobinsonDivision of Surgery and Cancer, Imperial College London, Liver Unit, St. Mary’s Hospital, South Wharf Road, Paddington, London W2 1NY, UKTel +44 20 3312 6199Email s.taylor-robinson@imperial.ac.ukAim: Cholangiocarcinoma is endemic in southeast Asia, generally developing from liver fluke infestation. However, diagnostic imaging of early-stage disease is challenging. The aim of this work is to investigate relaxometry (specifically, T2 mapping) as a method of exploiting the higher signal-to-noise ratio (SNR) of internal coils for improved reception of magnetic resonance signals, despite their non-uniform sensitivity.Methods: Ex vivo T2 mapping was carried out at 3T on fixed resection specimens from Thai cholangiocarcinoma patients using an mGRASE sequence and an endoscope coil based on a thin-film magneto-inductive waveguide and designed ultimately for internal use.Results: Disease-induced changes including granulomatous inflammation, intraepithelial neoplasia and intraductal tumours were correlated with histopathology, and relaxation data were compared with mono- and bi-exponential models of T2 relaxation. An approximately 10-fold local advantage in SNR compared to a 16-element torso coil was demonstrated using the endoscope coil, and improved tissue differentiation was obtained without contrast agents.Conclusion: The performance advantage above follows directly from the inverse relation between the component of the standard deviation of T2 due to thermal noise and the SNR, and offers an effective method of exploiting the SNR advantage of internal coils. No correction is required, avoiding the need for tracking, relaxing constraints on coil and slice orientation and providing rapid visualization.Keywords: cholangiocarcinoma, T2 mapping, internal coilKhuntikeo NTitapun AChamadol NBoonphongsathien WSa-Ngiamwibool PTaylor-Robinson SDWadsworth CAZhang SKardoulaki EMYoung IRSyms RRADove Medical Pressarticlecholangiocarcinomat2 mappinginternal coilDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 12, Pp 29-39 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cholangiocarcinoma t2 mapping internal coil Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	cholangiocarcinoma t2 mapping internal coil Diseases of the digestive system. Gastroenterology RC799-869 Khuntikeo N Titapun A Chamadol N Boonphongsathien W Sa-Ngiamwibool P Taylor-Robinson SD Wadsworth CA Zhang S Kardoulaki EM Young IR Syms RRA Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping
description	Narong Khuntikeo, 1 Attapol Titapun, 1 Nittaya Chamadol, 2 Wuttisak Boonphongsathien, 2 Prakasit Sa-Ngiamwibool, 3 Simon D Taylor-Robinson, 4 Christopher A Wadsworth, 4 Shuo Zhang, 5 Evdokia M Kardoulaki, 6 Ian R Young 6,&dagger;, Richard RA Syms 6 1Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 2Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 3Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 4Division of Surgery and Cancer, Imperial College London, Liver Unit, St. Mary’s Hospital, London W2 1NY, UK; 5Philips Healthcare Germany, Health Systems, Clinical Science, Hamburg 22335, Germany; 6EEE Department, Imperial College, London SW7 2AZ, UK&dagger;Ian R Young passed away on September 27, 2019Correspondence: Simon D Taylor-RobinsonDivision of Surgery and Cancer, Imperial College London, Liver Unit, St. Mary’s Hospital, South Wharf Road, Paddington, London W2 1NY, UKTel +44 20 3312 6199Email s.taylor-robinson@imperial.ac.ukAim: Cholangiocarcinoma is endemic in southeast Asia, generally developing from liver fluke infestation. However, diagnostic imaging of early-stage disease is challenging. The aim of this work is to investigate relaxometry (specifically, T2 mapping) as a method of exploiting the higher signal-to-noise ratio (SNR) of internal coils for improved reception of magnetic resonance signals, despite their non-uniform sensitivity.Methods: Ex vivo T2 mapping was carried out at 3T on fixed resection specimens from Thai cholangiocarcinoma patients using an mGRASE sequence and an endoscope coil based on a thin-film magneto-inductive waveguide and designed ultimately for internal use.Results: Disease-induced changes including granulomatous inflammation, intraepithelial neoplasia and intraductal tumours were correlated with histopathology, and relaxation data were compared with mono- and bi-exponential models of T2 relaxation. An approximately 10-fold local advantage in SNR compared to a 16-element torso coil was demonstrated using the endoscope coil, and improved tissue differentiation was obtained without contrast agents.Conclusion: The performance advantage above follows directly from the inverse relation between the component of the standard deviation of T2 due to thermal noise and the SNR, and offers an effective method of exploiting the SNR advantage of internal coils. No correction is required, avoiding the need for tracking, relaxing constraints on coil and slice orientation and providing rapid visualization.Keywords: cholangiocarcinoma, T2 mapping, internal coil
format	article
author	Khuntikeo N Titapun A Chamadol N Boonphongsathien W Sa-Ngiamwibool P Taylor-Robinson SD Wadsworth CA Zhang S Kardoulaki EM Young IR Syms RRA
author_facet	Khuntikeo N Titapun A Chamadol N Boonphongsathien W Sa-Ngiamwibool P Taylor-Robinson SD Wadsworth CA Zhang S Kardoulaki EM Young IR Syms RRA
author_sort	Khuntikeo N
title	Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping
title_short	Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping
title_full	Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping
title_fullStr	Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping
title_full_unstemmed	Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping
title_sort	improving the detection of cholangiocarcinoma: in vitro mri-based study using local coils and t2 mapping
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/31d143efa27f4cb4b7486ead4112c669
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Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping

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