Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry

Cysteine palmitoylation affects the localization and function of membrane proteins, but its stoichiometry and specificity are not well understood. Here, the authors show that palmitoylation is a stochastic process that depends on the accessibility of cysteines rather than a defined substrate motif.

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Autores principales:	Remco N. P. Rodenburg, Joost Snijder, Michiel van de Waterbeemd, Arie Schouten, Joke Granneman, Albert J. R. Heck, Piet Gros
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31d2d794c1834117b8a67cef2fedf804
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spelling	oai:doaj.org-article:31d2d794c1834117b8a67cef2fedf8042021-12-02T14:42:40ZStochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry10.1038/s41467-017-01461-z2041-1723https://doaj.org/article/31d2d794c1834117b8a67cef2fedf8042017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01461-zhttps://doaj.org/toc/2041-1723Cysteine palmitoylation affects the localization and function of membrane proteins, but its stoichiometry and specificity are not well understood. Here, the authors show that palmitoylation is a stochastic process that depends on the accessibility of cysteines rather than a defined substrate motif.Remco N. P. RodenburgJoost SnijderMichiel van de WaterbeemdArie SchoutenJoke GrannemanAlbert J. R. HeckPiet GrosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Remco N. P. Rodenburg Joost Snijder Michiel van de Waterbeemd Arie Schouten Joke Granneman Albert J. R. Heck Piet Gros Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry
description	Cysteine palmitoylation affects the localization and function of membrane proteins, but its stoichiometry and specificity are not well understood. Here, the authors show that palmitoylation is a stochastic process that depends on the accessibility of cysteines rather than a defined substrate motif.
format	article
author	Remco N. P. Rodenburg Joost Snijder Michiel van de Waterbeemd Arie Schouten Joke Granneman Albert J. R. Heck Piet Gros
author_facet	Remco N. P. Rodenburg Joost Snijder Michiel van de Waterbeemd Arie Schouten Joke Granneman Albert J. R. Heck Piet Gros
author_sort	Remco N. P. Rodenburg
title	Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry
title_short	Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry
title_full	Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry
title_fullStr	Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry
title_full_unstemmed	Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry
title_sort	stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/31d2d794c1834117b8a67cef2fedf804
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Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry

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