DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY

Objective: To detect ADAMTS-13 deficiency in sepsis patients and its effect on in-hospital morbidity and mortality in adult patients of sepsis. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology (AFIP) and Combined Military Hospital (CMH) Rawa...

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Autores principales:	Syed Owais Ali, Chaudhry Altaf Hussain, Dawood Ahmad, Rafia Mahmood, Syeda Sarwat Fatima, Taqdees Fatima
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	a disintegrin and metalloprotease with a thrombospondin type1 motif member 13 disseminated intravascular coagulation enzyme-linked immunosorbent assay thrombotic thrombocytopenic purpura Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71iSuppl-1.6210 https://doaj.org/article/31d4ef9cc276413cb4b3d3aec0a74b81
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spelling	oai:doaj.org-article:31d4ef9cc276413cb4b3d3aec0a74b812021-12-02T17:18:43ZDEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITYhttps://doi.org/10.51253/pafmj.v71iSuppl-1.62100030-96482411-8842https://doaj.org/article/31d4ef9cc276413cb4b3d3aec0a74b812021-01-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/6210https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To detect ADAMTS-13 deficiency in sepsis patients and its effect on in-hospital morbidity and mortality in adult patients of sepsis. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology (AFIP) and Combined Military Hospital (CMH) Rawalpindi, from Apr 2017 to Apr 2018. Methodology: All indoor patients admitted at Combined Military Hospital Rawalpindi and diagnosed as suffering from sepsis at Armed Forces Institute of Pathology according to the guidelines of the Critical Care Society of Medicine Consensus Conference Committee. Forty sepsis patients were recruited for the study. Two groups were formed on the basis of ADAMTS-13 antigen levels, non-deficient and deficient. Basic haematological and clinical parameters were recorded. Levels of ADAMTS-13 antigen were analyzed by using Technozyme kit byenzyme-linked immunosorbent assay (ELISA) and level less than 0.40 IU/ml was taken deficient as defined by manufacturer. Comparison was done between ADAMTS-13 deficient and non-deficient group with regard to clinical and haematological characteristics, ICU stay, hospital admission days and in-hospital mortality. Healthy controls of same age and gender were also observed for ADAMTS-13 antigen level. Results: Among total 40 sepsis patients, thirty two (80%) were males and eight (20%) were females with a mean age of 61 ± 15 years (range: 30-85 years). ADAMTS-13 deficiency (<0.40 IU/ml) was found in 28 (70%) of patients while 12 (30%) had normal antigen levels. In patients with ADAMTS-13 deficiency, twenty four (85.7%) had low platelet levels <150 x 109/l, mean hospital stay 19.2 ± 7.6 days and in-hospital mortality was seen in eight (28.6%) patients, in comparison of non-deficient group in which platelet levels were equal or >150 x 109/l, mean hospital stay was 10.2 ± 3.6 days and in-hospital mortality was in one (8.3%) patient respectively. ADAMTS-13 antigen level was found sufficient in healthy controls. Conclusion: Majority of the sepsis patients were found ADAMTS-13 deficient. Deficiency exhibit long term hospital admission, thrombocytopenia and increase in hospital mortality. ADAMTS-13 deficiency might play a role in sepsis induced thrombocytopenia and in hospital mortality. More studies are recommended on the subject with larger sample size to evaluate its role in sepsisSyed Owais AliChaudhry Altaf HussainDawood AhmadRafia MahmoodSyeda Sarwat FatimaTaqdees FatimaArmy Medical College Rawalpindiarticlea disintegrin and metalloprotease with a thrombospondin type1 motifmember 13disseminated intravascular coagulationenzyme-linked immunosorbent assaythrombotic thrombocytopenic purpuraMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss SUPPL-1, Pp 158-163 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	a disintegrin and metalloprotease with a thrombospondin type1 motif member 13 disseminated intravascular coagulation enzyme-linked immunosorbent assay thrombotic thrombocytopenic purpura Medicine R Medicine (General) R5-920
spellingShingle	a disintegrin and metalloprotease with a thrombospondin type1 motif member 13 disseminated intravascular coagulation enzyme-linked immunosorbent assay thrombotic thrombocytopenic purpura Medicine R Medicine (General) R5-920 Syed Owais Ali Chaudhry Altaf Hussain Dawood Ahmad Rafia Mahmood Syeda Sarwat Fatima Taqdees Fatima DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY
description	Objective: To detect ADAMTS-13 deficiency in sepsis patients and its effect on in-hospital morbidity and mortality in adult patients of sepsis. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology (AFIP) and Combined Military Hospital (CMH) Rawalpindi, from Apr 2017 to Apr 2018. Methodology: All indoor patients admitted at Combined Military Hospital Rawalpindi and diagnosed as suffering from sepsis at Armed Forces Institute of Pathology according to the guidelines of the Critical Care Society of Medicine Consensus Conference Committee. Forty sepsis patients were recruited for the study. Two groups were formed on the basis of ADAMTS-13 antigen levels, non-deficient and deficient. Basic haematological and clinical parameters were recorded. Levels of ADAMTS-13 antigen were analyzed by using Technozyme kit byenzyme-linked immunosorbent assay (ELISA) and level less than 0.40 IU/ml was taken deficient as defined by manufacturer. Comparison was done between ADAMTS-13 deficient and non-deficient group with regard to clinical and haematological characteristics, ICU stay, hospital admission days and in-hospital mortality. Healthy controls of same age and gender were also observed for ADAMTS-13 antigen level. Results: Among total 40 sepsis patients, thirty two (80%) were males and eight (20%) were females with a mean age of 61 ± 15 years (range: 30-85 years). ADAMTS-13 deficiency (<0.40 IU/ml) was found in 28 (70%) of patients while 12 (30%) had normal antigen levels. In patients with ADAMTS-13 deficiency, twenty four (85.7%) had low platelet levels <150 x 109/l, mean hospital stay 19.2 ± 7.6 days and in-hospital mortality was seen in eight (28.6%) patients, in comparison of non-deficient group in which platelet levels were equal or >150 x 109/l, mean hospital stay was 10.2 ± 3.6 days and in-hospital mortality was in one (8.3%) patient respectively. ADAMTS-13 antigen level was found sufficient in healthy controls. Conclusion: Majority of the sepsis patients were found ADAMTS-13 deficient. Deficiency exhibit long term hospital admission, thrombocytopenia and increase in hospital mortality. ADAMTS-13 deficiency might play a role in sepsis induced thrombocytopenia and in hospital mortality. More studies are recommended on the subject with larger sample size to evaluate its role in sepsis
format	article
author	Syed Owais Ali Chaudhry Altaf Hussain Dawood Ahmad Rafia Mahmood Syeda Sarwat Fatima Taqdees Fatima
author_facet	Syed Owais Ali Chaudhry Altaf Hussain Dawood Ahmad Rafia Mahmood Syeda Sarwat Fatima Taqdees Fatima
author_sort	Syed Owais Ali
title	DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY
title_short	DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY
title_full	DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY
title_fullStr	DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY
title_full_unstemmed	DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY
title_sort	deficiency of adamts-13 in sepsis patients and its correlation with morbidity/ mortality
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71iSuppl-1.6210 https://doaj.org/article/31d4ef9cc276413cb4b3d3aec0a74b81
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DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY

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