Predictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis

Abstract Background Psoriasis is a multisystem inflammatory disorder with variable morphology, clinical pattern and multiple comorbidities. Interplay between genetic and environmental factors leading to an aberrant immune response in the skin may contribute to disease development. The assessment for...

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Autores principales:	Enas Zahran, Ali Youssof, Wafaa Shehata, Ahmed Bahgat, Emad Elshebiny
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Case–control study Rheumatoid factor Psoriasis Psoriatic arthritis Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/31d5d8e712a84a04abf51f6be390dfdd
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spelling	oai:doaj.org-article:31d5d8e712a84a04abf51f6be390dfdd2021-11-28T12:03:26ZPredictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis10.1186/s43162-021-00082-91110-77822090-9098https://doaj.org/article/31d5d8e712a84a04abf51f6be390dfdd2021-11-01T00:00:00Zhttps://doi.org/10.1186/s43162-021-00082-9https://doaj.org/toc/1110-7782https://doaj.org/toc/2090-9098Abstract Background Psoriasis is a multisystem inflammatory disorder with variable morphology, clinical pattern and multiple comorbidities. Interplay between genetic and environmental factors leading to an aberrant immune response in the skin may contribute to disease development. The assessment for risk factors, signs, and symptoms of potential comorbid diseases is an important component of patient management. The aim of this study is to determine rheumatoid factors (RF) positivity and its levels in psoriasis patients, and describe its relationship with the demographic and clinical characteristics, comorbidities, and disease patterns of psoriasis. Results Rheumatoid factor was positive in psoriatic patients more than control,30% of patients had positive rheumatoid factor while only 10% of control had positive results. Rheumatoid factor level was 63.8 ± 186.7 IU/ml in psoriasis vs. 9.3 ± 12.3 in control. Thirty percent of psoriasis patients have positive rheumatoid factor vs. 10% of control. There was no significant statistical difference between psoriasis patients with or without arthritis as regard rheumatoid factor positivity and titer; rheumatoid factor was positive in 20% in psoriatic patients with arthritis vs. 26% in psoriatic patients without arthritis. In psoriatic patients, the status of rheumatoid factor did not relate to disease severity, onset, course, site of affection, presence of scalp, nail affection, and presence of dactylitis (p value>0.5). Conclusion Psoriasis was associated with higher seropositivity of RF compared to age-matched non-psoriatic healthy controls. Occurrence and level of rheumatoid factor were not associated with severity or clinical pattern of psoriasis.Enas ZahranAli YoussofWafaa ShehataAhmed BahgatEmad ElshebinySpringerOpenarticleCase–control studyRheumatoid factorPsoriasisPsoriatic arthritisInternal medicineRC31-1245ENThe Egyptian Journal of Internal Medicine, Vol 33, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Case–control study Rheumatoid factor Psoriasis Psoriatic arthritis Internal medicine RC31-1245
spellingShingle	Case–control study Rheumatoid factor Psoriasis Psoriatic arthritis Internal medicine RC31-1245 Enas Zahran Ali Youssof Wafaa Shehata Ahmed Bahgat Emad Elshebiny Predictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis
description	Abstract Background Psoriasis is a multisystem inflammatory disorder with variable morphology, clinical pattern and multiple comorbidities. Interplay between genetic and environmental factors leading to an aberrant immune response in the skin may contribute to disease development. The assessment for risk factors, signs, and symptoms of potential comorbid diseases is an important component of patient management. The aim of this study is to determine rheumatoid factors (RF) positivity and its levels in psoriasis patients, and describe its relationship with the demographic and clinical characteristics, comorbidities, and disease patterns of psoriasis. Results Rheumatoid factor was positive in psoriatic patients more than control,30% of patients had positive rheumatoid factor while only 10% of control had positive results. Rheumatoid factor level was 63.8 ± 186.7 IU/ml in psoriasis vs. 9.3 ± 12.3 in control. Thirty percent of psoriasis patients have positive rheumatoid factor vs. 10% of control. There was no significant statistical difference between psoriasis patients with or without arthritis as regard rheumatoid factor positivity and titer; rheumatoid factor was positive in 20% in psoriatic patients with arthritis vs. 26% in psoriatic patients without arthritis. In psoriatic patients, the status of rheumatoid factor did not relate to disease severity, onset, course, site of affection, presence of scalp, nail affection, and presence of dactylitis (p value>0.5). Conclusion Psoriasis was associated with higher seropositivity of RF compared to age-matched non-psoriatic healthy controls. Occurrence and level of rheumatoid factor were not associated with severity or clinical pattern of psoriasis.
format	article
author	Enas Zahran Ali Youssof Wafaa Shehata Ahmed Bahgat Emad Elshebiny
author_facet	Enas Zahran Ali Youssof Wafaa Shehata Ahmed Bahgat Emad Elshebiny
author_sort	Enas Zahran
title	Predictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis
title_short	Predictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis
title_full	Predictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis
title_fullStr	Predictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis
title_full_unstemmed	Predictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis
title_sort	predictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/31d5d8e712a84a04abf51f6be390dfdd
work_keys_str_mv	AT enaszahran predictiveroleofserumrheumatoidfactorindifferentdiseasepatternofpsoriasisandpsoriaticarthritis AT aliyoussof predictiveroleofserumrheumatoidfactorindifferentdiseasepatternofpsoriasisandpsoriaticarthritis AT wafaashehata predictiveroleofserumrheumatoidfactorindifferentdiseasepatternofpsoriasisandpsoriaticarthritis AT ahmedbahgat predictiveroleofserumrheumatoidfactorindifferentdiseasepatternofpsoriasisandpsoriaticarthritis AT emadelshebiny predictiveroleofserumrheumatoidfactorindifferentdiseasepatternofpsoriasisandpsoriaticarthritis
_version_	1718408250964049920

Predictive role of serum rheumatoid factor in different disease pattern of psoriasis and psoriatic arthritis

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