Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones

Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones

Stereodivergent construction of adjacent quaternary-quaternary stereocenters remains a formidable synthetic challenge. Here, the authors report a nickel-catalyzed enantioselective dearomatization Claisen rearrangement leading to vicinal all-carbon stereocentres and apply it to the stereodivergent sy...

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Autores principales: Haifeng Zheng, Yan Wang, Chaoran Xu, Xi Xu, Lili Lin, Xiaohua Liu, Xiaoming Feng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/31d983a6dc334dfe80c67deb1cef5dda
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spelling oai:doaj.org-article:31d983a6dc334dfe80c67deb1cef5dda2021-12-02T16:50:06ZStereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones10.1038/s41467-018-04123-w2041-1723https://doaj.org/article/31d983a6dc334dfe80c67deb1cef5dda2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04123-whttps://doaj.org/toc/2041-1723Stereodivergent construction of adjacent quaternary-quaternary stereocenters remains a formidable synthetic challenge. Here, the authors report a nickel-catalyzed enantioselective dearomatization Claisen rearrangement leading to vicinal all-carbon stereocentres and apply it to the stereodivergent synthesis of bioactive hyperolactones.Haifeng ZhengYan WangChaoran XuXi XuLili LinXiaohua LiuXiaoming FengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Haifeng Zheng
Yan Wang
Chaoran Xu
Xi Xu
Lili Lin
Xiaohua Liu
Xiaoming Feng
Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones
description Stereodivergent construction of adjacent quaternary-quaternary stereocenters remains a formidable synthetic challenge. Here, the authors report a nickel-catalyzed enantioselective dearomatization Claisen rearrangement leading to vicinal all-carbon stereocentres and apply it to the stereodivergent synthesis of bioactive hyperolactones.
format article
author Haifeng Zheng
Yan Wang
Chaoran Xu
Xi Xu
Lili Lin
Xiaohua Liu
Xiaoming Feng
author_facet Haifeng Zheng
Yan Wang
Chaoran Xu
Xi Xu
Lili Lin
Xiaohua Liu
Xiaoming Feng
author_sort Haifeng Zheng
title Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones
title_short Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones
title_full Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones
title_fullStr Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones
title_full_unstemmed Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones
title_sort stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/31d983a6dc334dfe80c67deb1cef5dda
work_keys_str_mv AT haifengzheng stereodivergentsynthesisofvicinalquaternaryquaternarystereocentersandbioactivehyperolactones
AT yanwang stereodivergentsynthesisofvicinalquaternaryquaternarystereocentersandbioactivehyperolactones
AT chaoranxu stereodivergentsynthesisofvicinalquaternaryquaternarystereocentersandbioactivehyperolactones
AT xixu stereodivergentsynthesisofvicinalquaternaryquaternarystereocentersandbioactivehyperolactones
AT lililin stereodivergentsynthesisofvicinalquaternaryquaternarystereocentersandbioactivehyperolactones
AT xiaohualiu stereodivergentsynthesisofvicinalquaternaryquaternarystereocentersandbioactivehyperolactones
AT xiaomingfeng stereodivergentsynthesisofvicinalquaternaryquaternarystereocentersandbioactivehyperolactones
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