YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity

Hippo TEAD-transcriptional regulators YAP1 and TAZ modulate cell growth, but the downstream networks are unclear. Here, the authors use a genetically-encoded inhibitor of YAP1/TAZ interaction with TEAD (TEADi) to disrupt transcriptional networks for cell cycle and terminal differentiation in human k...

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Autores principales:	Yao Yuan, Jeannie Park, Amber Feng, Parirokh Awasthi, Zhiyong Wang, Qianming Chen, Ramiro Iglesias-Bartolome
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31dca75ac3144d10befe559d4b9c7055
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spelling	oai:doaj.org-article:31dca75ac3144d10befe559d4b9c70552021-12-02T14:40:42ZYAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity10.1038/s41467-020-15301-02041-1723https://doaj.org/article/31dca75ac3144d10befe559d4b9c70552020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15301-0https://doaj.org/toc/2041-1723Hippo TEAD-transcriptional regulators YAP1 and TAZ modulate cell growth, but the downstream networks are unclear. Here, the authors use a genetically-encoded inhibitor of YAP1/TAZ interaction with TEAD (TEADi) to disrupt transcriptional networks for cell cycle and terminal differentiation in human keratinocytes and mouse skin.Yao YuanJeannie ParkAmber FengParirokh AwasthiZhiyong WangQianming ChenRamiro Iglesias-BartolomeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yao Yuan Jeannie Park Amber Feng Parirokh Awasthi Zhiyong Wang Qianming Chen Ramiro Iglesias-Bartolome YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity
description	Hippo TEAD-transcriptional regulators YAP1 and TAZ modulate cell growth, but the downstream networks are unclear. Here, the authors use a genetically-encoded inhibitor of YAP1/TAZ interaction with TEAD (TEADi) to disrupt transcriptional networks for cell cycle and terminal differentiation in human keratinocytes and mouse skin.
format	article
author	Yao Yuan Jeannie Park Amber Feng Parirokh Awasthi Zhiyong Wang Qianming Chen Ramiro Iglesias-Bartolome
author_facet	Yao Yuan Jeannie Park Amber Feng Parirokh Awasthi Zhiyong Wang Qianming Chen Ramiro Iglesias-Bartolome
author_sort	Yao Yuan
title	YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity
title_short	YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity
title_full	YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity
title_fullStr	YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity
title_full_unstemmed	YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity
title_sort	yap1/taz-tead transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting klf4 activity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/31dca75ac3144d10befe559d4b9c7055
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YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity

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