Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

Arterial pulsations are thought to drive CSF flow through perivascular spaces (PVSs), but this has never been quantitatively shown. Using particle tracking to quantify CSF flow velocities in PVSs of live mice, the authors show that flow speeds match the instantaneous speeds of the pulsing artery wal...

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Autores principales:	Humberto Mestre, Jeffrey Tithof, Ting Du, Wei Song, Weiguo Peng, Amanda M. Sweeney, Genaro Olveda, John H. Thomas, Maiken Nedergaard, Douglas H. Kelley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31e452ba634047b983250f695ea05139
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spelling	oai:doaj.org-article:31e452ba634047b983250f695ea051392021-12-02T17:33:02ZFlow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension10.1038/s41467-018-07318-32041-1723https://doaj.org/article/31e452ba634047b983250f695ea051392018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07318-3https://doaj.org/toc/2041-1723Arterial pulsations are thought to drive CSF flow through perivascular spaces (PVSs), but this has never been quantitatively shown. Using particle tracking to quantify CSF flow velocities in PVSs of live mice, the authors show that flow speeds match the instantaneous speeds of the pulsing artery walls that form the inner boundaries of the PVSs.Humberto MestreJeffrey TithofTing DuWei SongWeiguo PengAmanda M. SweeneyGenaro OlvedaJohn H. ThomasMaiken NedergaardDouglas H. KelleyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Humberto Mestre Jeffrey Tithof Ting Du Wei Song Weiguo Peng Amanda M. Sweeney Genaro Olveda John H. Thomas Maiken Nedergaard Douglas H. Kelley Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
description	Arterial pulsations are thought to drive CSF flow through perivascular spaces (PVSs), but this has never been quantitatively shown. Using particle tracking to quantify CSF flow velocities in PVSs of live mice, the authors show that flow speeds match the instantaneous speeds of the pulsing artery walls that form the inner boundaries of the PVSs.
format	article
author	Humberto Mestre Jeffrey Tithof Ting Du Wei Song Weiguo Peng Amanda M. Sweeney Genaro Olveda John H. Thomas Maiken Nedergaard Douglas H. Kelley
author_facet	Humberto Mestre Jeffrey Tithof Ting Du Wei Song Weiguo Peng Amanda M. Sweeney Genaro Olveda John H. Thomas Maiken Nedergaard Douglas H. Kelley
author_sort	Humberto Mestre
title	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_short	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_full	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_fullStr	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_full_unstemmed	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_sort	flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/31e452ba634047b983250f695ea05139
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Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

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