A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade

Autophagy mediated by the conjugation pathway for ubiquitin-like proteins plays a key role in controlling homeostasis in eukaryotic cells. Here the authors provide a molecular basis for allosteric activation of the E2 ligase Atg3, uncovering the mechanism underlying Atg8 lipidation and a novel mecha...

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Autores principales:	Yumei Zheng, Yu Qiu, Christy R. R. Grace, Xu Liu, Daniel J. Klionsky, Brenda A. Schulman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31e453d528f34bdaab754c8b28dc9d41
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id	oai:doaj.org-article:31e453d528f34bdaab754c8b28dc9d41
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spelling	oai:doaj.org-article:31e453d528f34bdaab754c8b28dc9d412021-12-02T16:57:51ZA switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade10.1038/s41467-019-11435-y2041-1723https://doaj.org/article/31e453d528f34bdaab754c8b28dc9d412019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11435-yhttps://doaj.org/toc/2041-1723Autophagy mediated by the conjugation pathway for ubiquitin-like proteins plays a key role in controlling homeostasis in eukaryotic cells. Here the authors provide a molecular basis for allosteric activation of the E2 ligase Atg3, uncovering the mechanism underlying Atg8 lipidation and a novel mechanism regulating E1-E2-E3-mediated ubiquitin-like protein conjugation.Yumei ZhengYu QiuChristy R. R. GraceXu LiuDaniel J. KlionskyBrenda A. SchulmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yumei Zheng Yu Qiu Christy R. R. Grace Xu Liu Daniel J. Klionsky Brenda A. Schulman A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade
description	Autophagy mediated by the conjugation pathway for ubiquitin-like proteins plays a key role in controlling homeostasis in eukaryotic cells. Here the authors provide a molecular basis for allosteric activation of the E2 ligase Atg3, uncovering the mechanism underlying Atg8 lipidation and a novel mechanism regulating E1-E2-E3-mediated ubiquitin-like protein conjugation.
format	article
author	Yumei Zheng Yu Qiu Christy R. R. Grace Xu Liu Daniel J. Klionsky Brenda A. Schulman
author_facet	Yumei Zheng Yu Qiu Christy R. R. Grace Xu Liu Daniel J. Klionsky Brenda A. Schulman
author_sort	Yumei Zheng
title	A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade
title_short	A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade
title_full	A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade
title_fullStr	A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade
title_full_unstemmed	A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade
title_sort	switch element in the autophagy e2 atg3 mediates allosteric regulation across the lipidation cascade
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/31e453d528f34bdaab754c8b28dc9d41
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A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade

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