A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade
Autophagy mediated by the conjugation pathway for ubiquitin-like proteins plays a key role in controlling homeostasis in eukaryotic cells. Here the authors provide a molecular basis for allosteric activation of the E2 ligase Atg3, uncovering the mechanism underlying Atg8 lipidation and a novel mecha...
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Autores principales: | Yumei Zheng, Yu Qiu, Christy R. R. Grace, Xu Liu, Daniel J. Klionsky, Brenda A. Schulman |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/31e453d528f34bdaab754c8b28dc9d41 |
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