Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition

Abstract Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of...

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Autores principales:	Ashiq Masood, Trevor Christ, Samia Asif, Priya Rajakumar, Beth A. Gustafson, Leyla O. Shune, Ameen Salahudeen, Drew Nedvad, Suparna Nanua, Agne Paner, Timothy M. Kuzel, Mia Levy, Janakiraman Subramanian, Shahzad Raza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/31e8f416ebe34f07bee1c287af92fbac
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spelling	oai:doaj.org-article:31e8f416ebe34f07bee1c287af92fbac2021-12-02T13:17:50ZNon-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition10.1038/s41525-021-00186-92056-7944https://doaj.org/article/31e8f416ebe34f07bee1c287af92fbac2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41525-021-00186-9https://doaj.org/toc/2056-7944Abstract Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are not well characterized. Here, we report a case of a patient with relapsed and refractory NSMM with brain metastasis harboring a TFG-ALK fusion showing a dramatic and durable (over two years) response to commercially available anaplastic lymphoma kinase (ALK) inhibitors. The case emphasizes the beneficial role of molecular profiling in this target-poor disease.Ashiq MasoodTrevor ChristSamia AsifPriya RajakumarBeth A. GustafsonLeyla O. ShuneAmeen SalahudeenDrew NedvadSuparna NanuaAgne PanerTimothy M. KuzelMia LevyJanakiraman SubramanianShahzad RazaNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 6, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Ashiq Masood Trevor Christ Samia Asif Priya Rajakumar Beth A. Gustafson Leyla O. Shune Ameen Salahudeen Drew Nedvad Suparna Nanua Agne Paner Timothy M. Kuzel Mia Levy Janakiraman Subramanian Shahzad Raza Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
description	Abstract Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are not well characterized. Here, we report a case of a patient with relapsed and refractory NSMM with brain metastasis harboring a TFG-ALK fusion showing a dramatic and durable (over two years) response to commercially available anaplastic lymphoma kinase (ALK) inhibitors. The case emphasizes the beneficial role of molecular profiling in this target-poor disease.
format	article
author	Ashiq Masood Trevor Christ Samia Asif Priya Rajakumar Beth A. Gustafson Leyla O. Shune Ameen Salahudeen Drew Nedvad Suparna Nanua Agne Paner Timothy M. Kuzel Mia Levy Janakiraman Subramanian Shahzad Raza
author_facet	Ashiq Masood Trevor Christ Samia Asif Priya Rajakumar Beth A. Gustafson Leyla O. Shune Ameen Salahudeen Drew Nedvad Suparna Nanua Agne Paner Timothy M. Kuzel Mia Levy Janakiraman Subramanian Shahzad Raza
author_sort	Ashiq Masood
title	Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_short	Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_full	Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_fullStr	Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_full_unstemmed	Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition
title_sort	non-secretory multiple myeloma with unusual tfg-alk fusion showed dramatic response to alk inhibition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/31e8f416ebe34f07bee1c287af92fbac
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Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition

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