Rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers

Abstract Photo-induced rapid control of molecular assemblies, such as micelles and vesicles, enables effective and on-demand release of drugs or active components, with applications such as drug delivery systems (DDS) and cosmetics. Thus far, no attempts to optimize the responsiveness of photorespon...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Masaaki Akamatsu, Kazuki Kobayashi, Hiroki Iwase, Yoshifumi Sakaguchi, Risa Tanaka, Kenichi Sakai, Hideki Sakai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31f6ca379cd647f89b9cde4b151cff13
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:31f6ca379cd647f89b9cde4b151cff13
record_format	dspace
spelling	oai:doaj.org-article:31f6ca379cd647f89b9cde4b151cff132021-12-02T15:49:35ZRapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers10.1038/s41598-021-90097-72045-2322https://doaj.org/article/31f6ca379cd647f89b9cde4b151cff132021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90097-7https://doaj.org/toc/2045-2322Abstract Photo-induced rapid control of molecular assemblies, such as micelles and vesicles, enables effective and on-demand release of drugs or active components, with applications such as drug delivery systems (DDS) and cosmetics. Thus far, no attempts to optimize the responsiveness of photoresponsive molecular assemblies have been published. We previously reported photoresponsive surfactants bearing a lophine dimer moiety that exhibit fast photochromism in confined spaces, such as inside a molecular assembly. However, rapid control of the micelle structures and solubilization capacity have not yet been demonstrated. In the present work, photo-induced morphological changes in micelles were monitored using in-situ small-angle neutron scattering (SANS) and UV/Vis absorption spectroscopy. An amphiphilic lophine dimer (3TEG-LPD) formed elliptical micelles. These were rapidly elongated by ultraviolet light irradiation, which could be reversed by dark treatment, both within 60 s. For a solution of 3TEG-LPD micelles solubilizing calcein as a model drug molecule, fluorescence and SANS measurements indicated rapid release of the incorporated calcein into the bulk solvent under UV irradiation. Building on these results, we investigated rapid controlled release via hierarchical chemical processes: photoisomerization, morphological changes in the micelles, and drug release. This rapid controlled release system allows for effective and on-demand DDS.Masaaki AkamatsuKazuki KobayashiHiroki IwaseYoshifumi SakaguchiRisa TanakaKenichi SakaiHideki SakaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masaaki Akamatsu Kazuki Kobayashi Hiroki Iwase Yoshifumi Sakaguchi Risa Tanaka Kenichi Sakai Hideki Sakai Rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers
description	Abstract Photo-induced rapid control of molecular assemblies, such as micelles and vesicles, enables effective and on-demand release of drugs or active components, with applications such as drug delivery systems (DDS) and cosmetics. Thus far, no attempts to optimize the responsiveness of photoresponsive molecular assemblies have been published. We previously reported photoresponsive surfactants bearing a lophine dimer moiety that exhibit fast photochromism in confined spaces, such as inside a molecular assembly. However, rapid control of the micelle structures and solubilization capacity have not yet been demonstrated. In the present work, photo-induced morphological changes in micelles were monitored using in-situ small-angle neutron scattering (SANS) and UV/Vis absorption spectroscopy. An amphiphilic lophine dimer (3TEG-LPD) formed elliptical micelles. These were rapidly elongated by ultraviolet light irradiation, which could be reversed by dark treatment, both within 60 s. For a solution of 3TEG-LPD micelles solubilizing calcein as a model drug molecule, fluorescence and SANS measurements indicated rapid release of the incorporated calcein into the bulk solvent under UV irradiation. Building on these results, we investigated rapid controlled release via hierarchical chemical processes: photoisomerization, morphological changes in the micelles, and drug release. This rapid controlled release system allows for effective and on-demand DDS.
format	article
author	Masaaki Akamatsu Kazuki Kobayashi Hiroki Iwase Yoshifumi Sakaguchi Risa Tanaka Kenichi Sakai Hideki Sakai
author_facet	Masaaki Akamatsu Kazuki Kobayashi Hiroki Iwase Yoshifumi Sakaguchi Risa Tanaka Kenichi Sakai Hideki Sakai
author_sort	Masaaki Akamatsu
title	Rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers
title_short	Rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers
title_full	Rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers
title_fullStr	Rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers
title_full_unstemmed	Rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers
title_sort	rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/31f6ca379cd647f89b9cde4b151cff13
work_keys_str_mv	AT masaakiakamatsu rapidcontrolledreleasebyphotoirradiationusingmorphologicalchangesinmicellesformedbyamphiphiliclophinedimers AT kazukikobayashi rapidcontrolledreleasebyphotoirradiationusingmorphologicalchangesinmicellesformedbyamphiphiliclophinedimers AT hirokiiwase rapidcontrolledreleasebyphotoirradiationusingmorphologicalchangesinmicellesformedbyamphiphiliclophinedimers AT yoshifumisakaguchi rapidcontrolledreleasebyphotoirradiationusingmorphologicalchangesinmicellesformedbyamphiphiliclophinedimers AT risatanaka rapidcontrolledreleasebyphotoirradiationusingmorphologicalchangesinmicellesformedbyamphiphiliclophinedimers AT kenichisakai rapidcontrolledreleasebyphotoirradiationusingmorphologicalchangesinmicellesformedbyamphiphiliclophinedimers AT hidekisakai rapidcontrolledreleasebyphotoirradiationusingmorphologicalchangesinmicellesformedbyamphiphiliclophinedimers
_version_	1718385682129354752

Rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers

Ejemplares similares