The role of microfluidics in protein formulations with pre-programmed functional characteristics

Hu Meng,1,2,* Shuai Deng,1,2,* Yajing You,3 Hon Fai Chan1,2 1Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong, China; 2School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; 3Department of Immunology, School of...

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Autores principales:	Meng H, Deng S, You Y, Chan HF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	protein therapy microfluidics biofabrication controlled release Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/31faf4af8a3544c988335726ba26fb6a
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spelling	oai:doaj.org-article:31faf4af8a3544c988335726ba26fb6a2021-12-02T09:59:47ZThe role of microfluidics in protein formulations with pre-programmed functional characteristics1177-5491https://doaj.org/article/31faf4af8a3544c988335726ba26fb6a2018-12-01T00:00:00Zhttps://www.dovepress.com/the-role-of-microfluidics-in-protein-formulations-with-pre-programmed--peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Hu Meng,1,2,* Shuai Deng,1,2,* Yajing You,3 Hon Fai Chan1,2 1Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong, China; 2School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; 3Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, China *These authors contributed equally to this work Abstract: Protein-based therapies hold great promise for treating many diseases. Nevertheless, the challenges of producing therapies with targeted attributes via standardized processes may hinder the development of protein formulations and clinical translation of the advanced therapies. Microfluidics represents a promising technology to develop protein formulations with pre-programmed functional characteristics, including size, morphology, and controlled drug release property. In this review, we discuss some examples of adopting microfluidics for fabricating particle- and fiber/tube-based formulations and highlight the advantages of microfluidics-assisted fabrication. Keywords: protein therapy, microfluidics, biofabrication, controlled releaseMeng HDeng SYou YChan HFDove Medical Pressarticleprotein therapymicrofluidicsbiofabricationcontrolled releaseMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 12, Pp 191-197 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	protein therapy microfluidics biofabrication controlled release Medicine (General) R5-920
spellingShingle	protein therapy microfluidics biofabrication controlled release Medicine (General) R5-920 Meng H Deng S You Y Chan HF The role of microfluidics in protein formulations with pre-programmed functional characteristics
description	Hu Meng,1,2,* Shuai Deng,1,2,* Yajing You,3 Hon Fai Chan1,2 1Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong, China; 2School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; 3Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, China *These authors contributed equally to this work Abstract: Protein-based therapies hold great promise for treating many diseases. Nevertheless, the challenges of producing therapies with targeted attributes via standardized processes may hinder the development of protein formulations and clinical translation of the advanced therapies. Microfluidics represents a promising technology to develop protein formulations with pre-programmed functional characteristics, including size, morphology, and controlled drug release property. In this review, we discuss some examples of adopting microfluidics for fabricating particle- and fiber/tube-based formulations and highlight the advantages of microfluidics-assisted fabrication. Keywords: protein therapy, microfluidics, biofabrication, controlled release
format	article
author	Meng H Deng S You Y Chan HF
author_facet	Meng H Deng S You Y Chan HF
author_sort	Meng H
title	The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_short	The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_full	The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_fullStr	The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_full_unstemmed	The role of microfluidics in protein formulations with pre-programmed functional characteristics
title_sort	role of microfluidics in protein formulations with pre-programmed functional characteristics
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/31faf4af8a3544c988335726ba26fb6a
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_version_	1718397808442081280

The role of microfluidics in protein formulations with pre-programmed functional characteristics

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