Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity

Aim. To investigate the association of the GIPR gene polymorphisms rs2302382 and rs8111428 with increased risk of type 2 diabetes mellitus and abdominal obesity.Materials and methods. The study involved 163 patients with abdominal obesity (BMI, 39.5 ± 8.3 kg/m2; age, 44.7 ± 8.9 years; men, 61; women...

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Autores principales:	Daria S. Skuratovskaia, Maria A. Vasilenko, Nikolai S. Fattakhov, Elena V. Kirienkova, Natalia I. Mironyuk, Pavel A. Zatolokin, Larisa S. Litvinova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	diabetes mellitus type 2 incretins abdominal obesity polymorphism gipr insulin c-peptide Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/31fef091779a45a9a984177e798ad7a5
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spelling	oai:doaj.org-article:31fef091779a45a9a984177e798ad7a52021-11-14T09:00:20ZPathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity2072-03512072-037810.14341/DM7927https://doaj.org/article/31fef091779a45a9a984177e798ad7a52016-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7927https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To investigate the association of the GIPR gene polymorphisms rs2302382 and rs8111428 with increased risk of type 2 diabetes mellitus and abdominal obesity.Materials and methods. The study involved 163 patients with abdominal obesity (BMI, 39.5 ± 8.3 kg/m2; age, 44.7 ± 8.9 years; men, 61; women, 102), 72 with type 2 diabetes mellitus (BMI, 43.70 ± 9.32 kg/m2; age, 46.5 ± 10.1 years; men, 29; women, 43) and 91 patients without carbohydrate metabolism disorders (BMI, 36.13 ± 6.72 kg/m2; age, 43.93 ± 8.35 years; men, 32; women 59). The control group comprised 109 relatively healthy volunteers (BMI, 22.6 ± 2.7 kg/m2; age, 39.5 ± 7.6 years; men, 66; women, 43). Genotypes were analysed by real-time PCR and serum insulin and C-peptide levels were evaluated by ELISA.Results. The AA genotype in the rs2302382 polymorphism of GIPR was associated with an increased risk for type 2 diabetes mellitus in abdominal obesity and the CA genotype was associated with a reduced risk. In individuals with abdominal obesity and type 2 diabetes mellitus carrying the CA genotype in rs2302382 polymorphism of GIPR, serum insulin and C-peptide levels were elevated to 56.27 mU/L (55.49–58.41 mU/L) and 2.04 ng/ml (1.37–2.85 ng/ml), respectively (p < 0.05). In obese patients with the same genotype and without type 2 diabetes, serum insulin levels and C-peptide levels were 22.73 mU/L (19.07–25.76 mU/L) and 0.73 ng/ml (0.53–1.03 ng/ml), respectively (p < 0.05). The GIPR rs8111428 polymorphism was not associated with increased risk of type 2 diabetes mellitus in obesity for any of the groups examined.Conclusion. Serum insulin and C-peptide levels were increased in patients with abdominal obesity who were carriers of the CA genotype in the rs2302382 polymorphism of GIPR, which is associated with a decreased risk of type 2 diabetes mellitus in obesity compared with the CC genotype.Daria S. SkuratovskaiaMaria A. VasilenkoNikolai S. FattakhovElena V. KirienkovaNatalia I. MironyukPavel A. ZatolokinLarisa S. LitvinovaEndocrinology Research Centrearticlediabetes mellitus type 2incretinsabdominal obesitypolymorphismgiprinsulinc-peptideNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 6, Pp 457-463 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus type 2 incretins abdominal obesity polymorphism gipr insulin c-peptide Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus type 2 incretins abdominal obesity polymorphism gipr insulin c-peptide Nutritional diseases. Deficiency diseases RC620-627 Daria S. Skuratovskaia Maria A. Vasilenko Nikolai S. Fattakhov Elena V. Kirienkova Natalia I. Mironyuk Pavel A. Zatolokin Larisa S. Litvinova Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity
description	Aim. To investigate the association of the GIPR gene polymorphisms rs2302382 and rs8111428 with increased risk of type 2 diabetes mellitus and abdominal obesity.Materials and methods. The study involved 163 patients with abdominal obesity (BMI, 39.5 ± 8.3 kg/m2; age, 44.7 ± 8.9 years; men, 61; women, 102), 72 with type 2 diabetes mellitus (BMI, 43.70 ± 9.32 kg/m2; age, 46.5 ± 10.1 years; men, 29; women, 43) and 91 patients without carbohydrate metabolism disorders (BMI, 36.13 ± 6.72 kg/m2; age, 43.93 ± 8.35 years; men, 32; women 59). The control group comprised 109 relatively healthy volunteers (BMI, 22.6 ± 2.7 kg/m2; age, 39.5 ± 7.6 years; men, 66; women, 43). Genotypes were analysed by real-time PCR and serum insulin and C-peptide levels were evaluated by ELISA.Results. The AA genotype in the rs2302382 polymorphism of GIPR was associated with an increased risk for type 2 diabetes mellitus in abdominal obesity and the CA genotype was associated with a reduced risk. In individuals with abdominal obesity and type 2 diabetes mellitus carrying the CA genotype in rs2302382 polymorphism of GIPR, serum insulin and C-peptide levels were elevated to 56.27 mU/L (55.49–58.41 mU/L) and 2.04 ng/ml (1.37–2.85 ng/ml), respectively (p < 0.05). In obese patients with the same genotype and without type 2 diabetes, serum insulin levels and C-peptide levels were 22.73 mU/L (19.07–25.76 mU/L) and 0.73 ng/ml (0.53–1.03 ng/ml), respectively (p < 0.05). The GIPR rs8111428 polymorphism was not associated with increased risk of type 2 diabetes mellitus in obesity for any of the groups examined.Conclusion. Serum insulin and C-peptide levels were increased in patients with abdominal obesity who were carriers of the CA genotype in the rs2302382 polymorphism of GIPR, which is associated with a decreased risk of type 2 diabetes mellitus in obesity compared with the CC genotype.
format	article
author	Daria S. Skuratovskaia Maria A. Vasilenko Nikolai S. Fattakhov Elena V. Kirienkova Natalia I. Mironyuk Pavel A. Zatolokin Larisa S. Litvinova
author_facet	Daria S. Skuratovskaia Maria A. Vasilenko Nikolai S. Fattakhov Elena V. Kirienkova Natalia I. Mironyuk Pavel A. Zatolokin Larisa S. Litvinova
author_sort	Daria S. Skuratovskaia
title	Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity
title_short	Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity
title_full	Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity
title_fullStr	Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity
title_full_unstemmed	Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity
title_sort	pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/31fef091779a45a9a984177e798ad7a5
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Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity

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