TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients

Abstract Background The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin synthesis has been considered for possible ass...

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Autores principales:	Jadwiga Snarska, Ewa Fiedorowicz, Dominika Rozmus, Konrad Wroński, Maria Latacz, Natalia Kordulewska, Janusz Płomiński, Roman Grzybowski, Huub F.J. Savelkoul, Elżbieta Kostyra, Anna Cieślińska
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	AP Polymorphism Acute pancreatitis rs211105 TPH1 Tryptophan hydroxylase 1 Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/31ff4eaf50e44e12b1208130a13c5f04
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spelling	oai:doaj.org-article:31ff4eaf50e44e12b1208130a13c5f042021-11-14T12:16:51ZTPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients10.1186/s12876-021-02012-z1471-230Xhttps://doaj.org/article/31ff4eaf50e44e12b1208130a13c5f042021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02012-zhttps://doaj.org/toc/1471-230XAbstract Background The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin synthesis has been considered for possible associations in various diseases. Single-nucleotide polymorphisms (SNPs) in TPH genes have been already described in associations with psychiatric and digestive system disorders. This study aimed to explore the association of a rs211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentrations in blood serum in a population of acute pancreatitis patients, and to investigate this association with acute pancreatitis susceptibility. Results Our data showed an association between the presence of the T allele at the position rs211105 (OR = 2.47, 95 % CI 0.94–6.50, p = 0.06) under conditions of a decreased AP incidence. For TT and GT genotypes in the control group, the lowest concentration of TPH was associated with higher serotonin levels (TT: Rs = − 0.415, p = 0.0018; GT: Rs = − 0.457, p = 0.0066), while for the AP group the highest levels of TPH among the TT genotype were associated with lower levels of serotonin (TT: Rs = − 0.749, p < 0.0001, and in the GG genotype higher levels of TPH were associated with higher levels of serotonin (GG: Rs = − 0.738, p = 0.037). Conclusions Here, a new insight in the potential role of a selected genetic factor in pancreatitis development was shown. Not only the metabolic pathway of serotonin, but also factors affecting serotonin synthesis may be interesting and important points in acute pancreatitis.Jadwiga SnarskaEwa FiedorowiczDominika RozmusKonrad WrońskiMaria LataczNatalia KordulewskaJanusz PłomińskiRoman GrzybowskiHuub F.J. SavelkoulElżbieta KostyraAnna CieślińskaBMCarticleAPPolymorphismAcute pancreatitisrs211105TPH1Tryptophan hydroxylase 1Diseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AP Polymorphism Acute pancreatitis rs211105 TPH1 Tryptophan hydroxylase 1 Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	AP Polymorphism Acute pancreatitis rs211105 TPH1 Tryptophan hydroxylase 1 Diseases of the digestive system. Gastroenterology RC799-869 Jadwiga Snarska Ewa Fiedorowicz Dominika Rozmus Konrad Wroński Maria Latacz Natalia Kordulewska Janusz Płomiński Roman Grzybowski Huub F.J. Savelkoul Elżbieta Kostyra Anna Cieślińska TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients
description	Abstract Background The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin synthesis has been considered for possible associations in various diseases. Single-nucleotide polymorphisms (SNPs) in TPH genes have been already described in associations with psychiatric and digestive system disorders. This study aimed to explore the association of a rs211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentrations in blood serum in a population of acute pancreatitis patients, and to investigate this association with acute pancreatitis susceptibility. Results Our data showed an association between the presence of the T allele at the position rs211105 (OR = 2.47, 95 % CI 0.94–6.50, p = 0.06) under conditions of a decreased AP incidence. For TT and GT genotypes in the control group, the lowest concentration of TPH was associated with higher serotonin levels (TT: Rs = − 0.415, p = 0.0018; GT: Rs = − 0.457, p = 0.0066), while for the AP group the highest levels of TPH among the TT genotype were associated with lower levels of serotonin (TT: Rs = − 0.749, p < 0.0001, and in the GG genotype higher levels of TPH were associated with higher levels of serotonin (GG: Rs = − 0.738, p = 0.037). Conclusions Here, a new insight in the potential role of a selected genetic factor in pancreatitis development was shown. Not only the metabolic pathway of serotonin, but also factors affecting serotonin synthesis may be interesting and important points in acute pancreatitis.
format	article
author	Jadwiga Snarska Ewa Fiedorowicz Dominika Rozmus Konrad Wroński Maria Latacz Natalia Kordulewska Janusz Płomiński Roman Grzybowski Huub F.J. Savelkoul Elżbieta Kostyra Anna Cieślińska
author_facet	Jadwiga Snarska Ewa Fiedorowicz Dominika Rozmus Konrad Wroński Maria Latacz Natalia Kordulewska Janusz Płomiński Roman Grzybowski Huub F.J. Savelkoul Elżbieta Kostyra Anna Cieślińska
author_sort	Jadwiga Snarska
title	TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients
title_short	TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients
title_full	TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients
title_fullStr	TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients
title_full_unstemmed	TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients
title_sort	tph1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients
publisher	BMC
publishDate	2021
url	https://doaj.org/article/31ff4eaf50e44e12b1208130a13c5f04
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TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients

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