Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria

Abstract Purpose: The aim of this case–control study was to determine the impact of environmental factors on the predisposition to develop keratoconus in a sample of Western Algerian population. Subsequently, we were interested in the implication of two single nucleotide polymorphisms (SNPs) IL4 rs2...

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Autores principales:	Wafaa Meteoukki, Mostefa Fodil, Nawel Adda Negaz, Nesrine Rahmoun, Sarah Lardjam Hetraf, Hadjira Ouhaibi Djellouli, Ahlem Djelti Messal, Meriem Abdi, Meriem Samia Aberkane, Abdelillah Chiali, Amine Derdour, Aicha Idder, Faouzia Zemani -Fodil
Formato:	article
Lenguaje:	EN
Publicado:	Knowledge E 2021
Materias:	case–control study foxp3 gene il4 gene keratoconus polymorphisms western algeria Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/32001d19547b44c4a96dcc21ddf9395b
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spelling	oai:doaj.org-article:32001d19547b44c4a96dcc21ddf9395b2021-11-09T08:05:35ZAssociation of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria2008-20102008-322X10.18502/jovr.v16i4.9745https://doaj.org/article/32001d19547b44c4a96dcc21ddf9395b2021-10-01T00:00:00Zhttps://doi.org/10.18502/jovr.v16i4.9745https://doaj.org/toc/2008-2010https://doaj.org/toc/2008-322XAbstract Purpose: The aim of this case–control study was to determine the impact of environmental factors on the predisposition to develop keratoconus in a sample of Western Algerian population. Subsequently, we were interested in the implication of two single nucleotide polymorphisms (SNPs) IL4 rs2070874 and FOXP3 rs3761548, previously described as contributing to the occurrence of allergy, in the development of keratoconus. Methods: The study included 70 unrelated KC cases and 70 controls originating from Western Algeria. DNA genotyping was done using predesigned probe-based allelic discrimination TaqManⓇ assays. Allele and genotype frequencies were compared between the cases and controls by Chi-square test and odds ratios with 95% confidence intervals. Results: A significant association between risk factors such as family history, atopy, eye rubbing, and the development of keratoconus was found in our sample. Smoking would provide a protective effect against the pathology. No statistically significant differences were found in the allele and genotype frequencies between cases and controls neither for IL4 rs2070874 nor for FOXP3 rs3761548. Conclusion: Our study provides, for the first time, a clear demonstration of the absence of association of the allergy-associated IL4 and FOXP3 polymorphisms with KC in a sample from Western Algerian population.Wafaa MeteoukkiMostefa FodilNawel Adda NegazNesrine RahmounSarah Lardjam HetrafHadjira Ouhaibi DjellouliAhlem Djelti MessalMeriem AbdiMeriem Samia AberkaneAbdelillah ChialiAmine DerdourAicha IdderFaouzia Zemani -FodilKnowledge Earticlecase–control studyfoxp3 geneil4 genekeratoconuspolymorphismswestern algeriaOphthalmologyRE1-994ENJournal of Ophthalmic & Vision Research, Vol 16, Iss 4, Pp 558-565 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	case–control study foxp3 gene il4 gene keratoconus polymorphisms western algeria Ophthalmology RE1-994
spellingShingle	case–control study foxp3 gene il4 gene keratoconus polymorphisms western algeria Ophthalmology RE1-994 Wafaa Meteoukki Mostefa Fodil Nawel Adda Negaz Nesrine Rahmoun Sarah Lardjam Hetraf Hadjira Ouhaibi Djellouli Ahlem Djelti Messal Meriem Abdi Meriem Samia Aberkane Abdelillah Chiali Amine Derdour Aicha Idder Faouzia Zemani -Fodil Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria
description	Abstract Purpose: The aim of this case–control study was to determine the impact of environmental factors on the predisposition to develop keratoconus in a sample of Western Algerian population. Subsequently, we were interested in the implication of two single nucleotide polymorphisms (SNPs) IL4 rs2070874 and FOXP3 rs3761548, previously described as contributing to the occurrence of allergy, in the development of keratoconus. Methods: The study included 70 unrelated KC cases and 70 controls originating from Western Algeria. DNA genotyping was done using predesigned probe-based allelic discrimination TaqManⓇ assays. Allele and genotype frequencies were compared between the cases and controls by Chi-square test and odds ratios with 95% confidence intervals. Results: A significant association between risk factors such as family history, atopy, eye rubbing, and the development of keratoconus was found in our sample. Smoking would provide a protective effect against the pathology. No statistically significant differences were found in the allele and genotype frequencies between cases and controls neither for IL4 rs2070874 nor for FOXP3 rs3761548. Conclusion: Our study provides, for the first time, a clear demonstration of the absence of association of the allergy-associated IL4 and FOXP3 polymorphisms with KC in a sample from Western Algerian population.
format	article
author	Wafaa Meteoukki Mostefa Fodil Nawel Adda Negaz Nesrine Rahmoun Sarah Lardjam Hetraf Hadjira Ouhaibi Djellouli Ahlem Djelti Messal Meriem Abdi Meriem Samia Aberkane Abdelillah Chiali Amine Derdour Aicha Idder Faouzia Zemani -Fodil
author_facet	Wafaa Meteoukki Mostefa Fodil Nawel Adda Negaz Nesrine Rahmoun Sarah Lardjam Hetraf Hadjira Ouhaibi Djellouli Ahlem Djelti Messal Meriem Abdi Meriem Samia Aberkane Abdelillah Chiali Amine Derdour Aicha Idder Faouzia Zemani -Fodil
author_sort	Wafaa Meteoukki
title	Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria
title_short	Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria
title_full	Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria
title_fullStr	Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria
title_full_unstemmed	Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria
title_sort	association of il4 rs2070874, foxp3 rs3761548 polymorphisms with keratoconus in algeria
publisher	Knowledge E
publishDate	2021
url	https://doaj.org/article/32001d19547b44c4a96dcc21ddf9395b
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Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria

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