Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis

Abstract Dilated cardiomyopathy (DCM) is a disease of the heart muscle that affects both humans and dogs. Certain canine diets have been associated with DCM, but the diet-disease link is unexplained, and novel methods are needed to elucidate mechanisms. We conducted metabolomic profiling of 9 diets...

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Autores principales:	Caren E. Smith, Laurence D. Parnell, Chao-Qiang Lai, John E. Rush, Lisa M. Freeman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32015933ee4141a6baa177c2f0d8b689
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spelling	oai:doaj.org-article:32015933ee4141a6baa177c2f0d8b6892021-12-02T17:06:32ZInvestigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis10.1038/s41598-021-94464-22045-2322https://doaj.org/article/32015933ee4141a6baa177c2f0d8b6892021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94464-2https://doaj.org/toc/2045-2322Abstract Dilated cardiomyopathy (DCM) is a disease of the heart muscle that affects both humans and dogs. Certain canine diets have been associated with DCM, but the diet-disease link is unexplained, and novel methods are needed to elucidate mechanisms. We conducted metabolomic profiling of 9 diets associated with canine DCM, containing ≥ 3 pulses, potatoes, or sweet potatoes as main ingredients, and in the top 16 dog diet brands most frequently associated with canine DCM cases reported to the FDA (3P/FDA diets), and 9 non-3P/FDA diets. We identified 88 named biochemical compounds that were higher in 3P/FDA diets and 23 named compounds that were lower in 3P/FDA diets. Amino acids, amino acid-derived compounds, and xenobiotics/plant compounds were the largest categories of biochemicals that were higher in 3P/FDA diets. Random forest analyses identified the top 30 compounds that distinguished the two diet groups with 100% predictive accuracy. Four diet ingredients distinguished the two diet groups (peas, lentils, chicken/turkey, and rice). Of these ingredients, peas showed the greatest association with higher concentrations of compounds in 3P/FDA diets. Moreover, the current foodomics analyses highlight relationships between diet and DCM in dogs that can identify possible etiologies for understanding diet-disease relationships in dogs and humans.Caren E. SmithLaurence D. ParnellChao-Qiang LaiJohn E. RushLisa M. FreemanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caren E. Smith Laurence D. Parnell Chao-Qiang Lai John E. Rush Lisa M. Freeman Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis
description	Abstract Dilated cardiomyopathy (DCM) is a disease of the heart muscle that affects both humans and dogs. Certain canine diets have been associated with DCM, but the diet-disease link is unexplained, and novel methods are needed to elucidate mechanisms. We conducted metabolomic profiling of 9 diets associated with canine DCM, containing ≥ 3 pulses, potatoes, or sweet potatoes as main ingredients, and in the top 16 dog diet brands most frequently associated with canine DCM cases reported to the FDA (3P/FDA diets), and 9 non-3P/FDA diets. We identified 88 named biochemical compounds that were higher in 3P/FDA diets and 23 named compounds that were lower in 3P/FDA diets. Amino acids, amino acid-derived compounds, and xenobiotics/plant compounds were the largest categories of biochemicals that were higher in 3P/FDA diets. Random forest analyses identified the top 30 compounds that distinguished the two diet groups with 100% predictive accuracy. Four diet ingredients distinguished the two diet groups (peas, lentils, chicken/turkey, and rice). Of these ingredients, peas showed the greatest association with higher concentrations of compounds in 3P/FDA diets. Moreover, the current foodomics analyses highlight relationships between diet and DCM in dogs that can identify possible etiologies for understanding diet-disease relationships in dogs and humans.
format	article
author	Caren E. Smith Laurence D. Parnell Chao-Qiang Lai John E. Rush Lisa M. Freeman
author_facet	Caren E. Smith Laurence D. Parnell Chao-Qiang Lai John E. Rush Lisa M. Freeman
author_sort	Caren E. Smith
title	Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis
title_short	Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis
title_full	Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis
title_fullStr	Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis
title_full_unstemmed	Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis
title_sort	investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/32015933ee4141a6baa177c2f0d8b689
work_keys_str_mv	AT carenesmith investigationofdietsassociatedwithdilatedcardiomyopathyindogsusingfoodomicsanalysis AT laurencedparnell investigationofdietsassociatedwithdilatedcardiomyopathyindogsusingfoodomicsanalysis AT chaoqianglai investigationofdietsassociatedwithdilatedcardiomyopathyindogsusingfoodomicsanalysis AT johnerush investigationofdietsassociatedwithdilatedcardiomyopathyindogsusingfoodomicsanalysis AT lisamfreeman investigationofdietsassociatedwithdilatedcardiomyopathyindogsusingfoodomicsanalysis
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Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis

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