Brazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice

Background: Lychnophora ericoides Mart. (Asteraceae) is a Brazilian plant commonly used in folk medicine to treat pain and inflammation by topical administration. In recent years, this medicine has begun to be used orally. However, no study concerning its toxicity profile has been reported. Objectiv...

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Autores principales:	Barbhara Mota Marinho, Victor Hugo Dantas Guimarães, Jaciara Neves Sousa, Daniel Silva Moraes, Emisael Stênio Batista Gomes, Cláudia Regina Vieira, Sidnei Tavares dos Reis, Theles de Oliveira Costa, Lucyana Conceição Farias, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Sérgio Henrique Sousa Santos
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Lychnophora ericoides mart Brazilian arnica Acute toxicity Subagude toxicity Brazilian-savanna Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/3203257ec673416abc42cf23107da8f4
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spelling	oai:doaj.org-article:3203257ec673416abc42cf23107da8f42021-11-16T04:11:39ZBrazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice2667-031310.1016/j.phyplu.2021.100154https://doaj.org/article/3203257ec673416abc42cf23107da8f42022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667031321001366https://doaj.org/toc/2667-0313Background: Lychnophora ericoides Mart. (Asteraceae) is a Brazilian plant commonly used in folk medicine to treat pain and inflammation by topical administration. In recent years, this medicine has begun to be used orally. However, no study concerning its toxicity profile has been reported. Objective: The study evaluates the potential toxicity of the ethanolic extract from leaves of the Lychnophora ericoides, through the methods of acute and sub-acute oral administration in mice. Method: An acute toxicity study was performed according to the Organization for Economic Cooperation and Development protocol (OECD 423). A single extract dose of 50, 300, and 2000 mg/kg (n = 3/group) was administered orally to female Swiss mice. For subacute toxicity, the protocol OECD 407 was followed. Doses of 50, 300, and 500 mg/kg (n = 10/group) of the extract were administered daily to Swiss mice of both sexes for 28 days. Abnormal behavior, muscle strength, toxic symptoms, weight, and death were observed when assessing toxicity. Biochemical analysis, hematological analysis, macroscopic examination, and histopathological examination of several organs were conducted at the end of the treatment period. Results: In acute and subacute toxicity, the extract did not produce mortality. The acute toxicity study revealed alterations in the behavioral test and histopathological changes in the liver, kidney, lung, and spleen. The subacute oral toxicity test showed changes in hematologic and biochemical parameters. Histopathological examination of liver, kidney, spleen, lung, and heart indicated degenerative characteristics with inflammatory infiltrates focus. Conclusion: The study results suggest that oral use of Lychnophora ericoides leaves extract should be performed with caution in low doses in both single and repeated administrations.Barbhara Mota MarinhoVictor Hugo Dantas GuimarãesJaciara Neves SousaDaniel Silva MoraesEmisael Stênio Batista GomesCláudia Regina VieiraSidnei Tavares dos ReisTheles de Oliveira CostaLucyana Conceição FariasAndré Luiz Sena GuimarãesAlfredo Maurício Batista de PaulaSérgio Henrique Sousa SantosElsevierarticleLychnophora ericoides martBrazilian arnicaAcute toxicitySubagude toxicityBrazilian-savannaOther systems of medicineRZ201-999ENPhytomedicine Plus, Vol 2, Iss 1, Pp 100154- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lychnophora ericoides mart Brazilian arnica Acute toxicity Subagude toxicity Brazilian-savanna Other systems of medicine RZ201-999
spellingShingle	Lychnophora ericoides mart Brazilian arnica Acute toxicity Subagude toxicity Brazilian-savanna Other systems of medicine RZ201-999 Barbhara Mota Marinho Victor Hugo Dantas Guimarães Jaciara Neves Sousa Daniel Silva Moraes Emisael Stênio Batista Gomes Cláudia Regina Vieira Sidnei Tavares dos Reis Theles de Oliveira Costa Lucyana Conceição Farias André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos Brazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice
description	Background: Lychnophora ericoides Mart. (Asteraceae) is a Brazilian plant commonly used in folk medicine to treat pain and inflammation by topical administration. In recent years, this medicine has begun to be used orally. However, no study concerning its toxicity profile has been reported. Objective: The study evaluates the potential toxicity of the ethanolic extract from leaves of the Lychnophora ericoides, through the methods of acute and sub-acute oral administration in mice. Method: An acute toxicity study was performed according to the Organization for Economic Cooperation and Development protocol (OECD 423). A single extract dose of 50, 300, and 2000 mg/kg (n = 3/group) was administered orally to female Swiss mice. For subacute toxicity, the protocol OECD 407 was followed. Doses of 50, 300, and 500 mg/kg (n = 10/group) of the extract were administered daily to Swiss mice of both sexes for 28 days. Abnormal behavior, muscle strength, toxic symptoms, weight, and death were observed when assessing toxicity. Biochemical analysis, hematological analysis, macroscopic examination, and histopathological examination of several organs were conducted at the end of the treatment period. Results: In acute and subacute toxicity, the extract did not produce mortality. The acute toxicity study revealed alterations in the behavioral test and histopathological changes in the liver, kidney, lung, and spleen. The subacute oral toxicity test showed changes in hematologic and biochemical parameters. Histopathological examination of liver, kidney, spleen, lung, and heart indicated degenerative characteristics with inflammatory infiltrates focus. Conclusion: The study results suggest that oral use of Lychnophora ericoides leaves extract should be performed with caution in low doses in both single and repeated administrations.
format	article
author	Barbhara Mota Marinho Victor Hugo Dantas Guimarães Jaciara Neves Sousa Daniel Silva Moraes Emisael Stênio Batista Gomes Cláudia Regina Vieira Sidnei Tavares dos Reis Theles de Oliveira Costa Lucyana Conceição Farias André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos
author_facet	Barbhara Mota Marinho Victor Hugo Dantas Guimarães Jaciara Neves Sousa Daniel Silva Moraes Emisael Stênio Batista Gomes Cláudia Regina Vieira Sidnei Tavares dos Reis Theles de Oliveira Costa Lucyana Conceição Farias André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos
author_sort	Barbhara Mota Marinho
title	Brazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice
title_short	Brazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice
title_full	Brazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice
title_fullStr	Brazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice
title_full_unstemmed	Brazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice
title_sort	brazilian cerrado plant (arnica) lychnophora ericoides mart. (asteraceae) toxicity characterization in mice
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/3203257ec673416abc42cf23107da8f4
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Brazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice

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